Efeito do ácido tranexâmico associado à cola de fibrina sobre o reparo ósseo: estudo histológico em ratos

The bone repair process is controlled by complex molecular mechanisms that involve systemic and local factors. Fibrin glue is derived from human plasma and mimics the final pathway of coagulation network. Tranexamic acid inhibits fibrinolysis and prevents or decreases the formation of degradation products of fibrin and fibrinogen. The purpose of this study was to evaluate histologically in rats the effect of tranexamic acid associated with the fibrin glue on bone healing. The experiment used 60 (n = 5) male rats in: GI: Control, GII: fibrin glue, GIII tranexamic acid and GIV /fibrin glue/tranexamic acid. Bone defect (2.5mm diameter) was created in right tibia. The animals were euthanized at 7,14 and 30 days postoperatively, and the pieces were processed with hematoxylin and eosin. The results showed at 7 days post-operative surgical cavity filled with dense connective tissue rich in fibroblasts, permeated by delicate neoformed bone trabeculae in percentage of 70-80% for GI, GII and GIII and GIV to 94.8%. At 14 days post-operative newly formed bone was found between 75-85% for GI, GII and GIII and percentage above 95% for GIV. At 30 days postoperative GI and GIV showed 95-100% of mature bone tissue; GII and GIII in percentage close to 80-90%. Based on the results and methodology is concluded that fibrin / tranexamic acid glue association has positive action on bone repair.

Avaliação Histológica e histomorfométrica do reparo ósseo em tíbias osteotomizadas de ratos (rattus novergicus albinus), submetidos a tratamento com ultrassom, frente à presença e ausência de carga

The response of bone metabolism is directly related to hormonal factors and mechanical stimuli that the bone is exposed. The ultrasonic energy on bone healing have been shown to be crucial for the stimulation and improvement in quality of newly formed tissue. The aim of this study was to analyze the action of low intensity ultrasound on bone healing of tibial osteotomy in rats subjected to tail suspension, through histological analysis and histomorphometry. Eighteen Rattus norvegicus albinos, Wistar, adults were divided into three groups, arranged as follows: G1 (n = 6), who remained free for a period of 15 days, G2 (n = 5), suspended by the tail for a period of 15 days and G3 (n = 7), suspended by the tail for a period of 36 days. In all three groups, both tibias were subjected to mono-cortical bone injury 4X2 mm in the medial region of the diaphysis, and the left limb was used as control and the right limb undergoing treatment with ultrasound (U.S.). The right tibia was treated with pulsed ultrasound at a frequency of 1.5 MHz, duty cycle 1:4, 30mW/cm2, for 12 sessions of 20 minutes each. Samples of tibia were subjected to histological analysis, blindly, with light microscopy and histomorphometric analysis by specific software Image-Pro 6.1. The average percentage of new bone formation were subjected to analysis of variance in subdivided parcels and multiple comparison test "Student-Newman-Keuls (SNK), with a significance level of 5%. The average values and standard deviations of the percentage of newly formed bone for the groups showed the least amount of bone repair G1t (13.62% ± 4.88%) - G1c (8.68% ± 4.16%) compared G2t groups (27.17% ± 11.36%) - G2c (10.10% ± 7.90%) and G3t (23.19% ± 5.61%) - G3c (15.74% ± 7 08%). However, the mean values and standard deviations of the percentage of newly formed bone repair in the tibia treated G2t and G3t were significantly higher when compared to the repair of tibia in the control group (G2c and G3c). Consequently, we conclude that ultrasound has helped to accelerate bone repair in both the presence and absence of cargo.

Combinação de técnicas para tratamento cirúrgico de fratura do complexo zigomático-maxilar: relato de caso

The zygomatic-maxillary complex due to its projection framed as one of the areas hardest hit by injuries, as well as the nasal bones. Component important in this context, the zygomatic arch fracture is under the direct action of forces due to its structure fragile, resulting in loss of normal convex curvature. Therefore, it is aimed to report a clinical case of male patient, who had leucoderma zygomatic bone fracture using access transcutaneous and intra-oral fracture reduction body of zygoma and zygomatic arch. In addition to evidence combination of closed and open techniques for solving the case. The technique provided the patient excellent cosmetic and functional results.

Sobredentaduras mandibulares inmediatas: revisión de literatura

Conventional complete denture even though well confectioned, could present deficiencies in the retention, stability and support, in addition uncomfortable and retention of food below it. The overdentures have been considered an alternative to resolve problems and negative experiences with the conventional dentures, thus also can be an alternative to the complex treatments (surgical/prosthetic) with implant-supported prosthesis. In the attempt to reduce the healing time for the confection of the dentures showed higher rates of success to the implants when immediate mandibular overdentures were used in the rehabilitation of edentulous patients. The aim of this paper was to discuss by means of a Literature review, the viability of the use of mandibular implant-supported overdentures. The immediate mandibular overdentures have been showed like a reproducible method, predictable and confidence to provide an efficient function to the total edentulous patients.

La Práctica de Recapsular Agujas por Profesionales de la Salud y Condiciones de los Depósitos de Material Corto-Punzante

El objetivo de este trabajo fue verificar la adhesión a la sugerencia de no recapsular agujas, basado en el comportamiento revelado por los cirujanos dentistas de la red municipal de salud bucal de la ciudad de Araçatuba en el estado de Sao Paulo, así como también observar la presencia de depósitos de material corto-punzante, las condiciones de llenado (por sobre el nivel recomendado o no) y su ubicación (cerca o lejos del profesional). Se recolectaron los contenedores de todas las unidades odontológicas de la red municipal. Después de la separación de otros elementos corto-punzante y materiales, además de la selección según como se recapsuló, se procedió al conteo de las agujas con la ayuda de una pinza larga y colocadas sobre una mesa revestida. Del total de 48 unidades odontológicas, se recolectaron 38 contenedores de elementos cortopunzantes con 5591 agujas desechadas. De estas, 2384 (42.7%) estaban recapsuladas por los dos lados, 2.177 (38.9%) en un lado y 1.030 (18.4%) sin recubrimiento. Se concluye que el índice de apego de estos profesionales a la recomendación de no recapsular las agujas es bajo. Los contenedores eran en la mayoría del tipo “Descarpak” y no estaban rellenados encima del nivel indicado; y a la vez se encontraban alejados del responsable de los desechos.

Fasceíte necrotizante: relato de dois casos

Necrotizing fasciitis is a rare dermatopathy that promotes subcutaneous tissue damage, associated to substantial morbidity and mortality if treatment is not initiated at the beginning of the condition. The objective of the present study is to report the occurrence of two cases of necrotizing fasciitis, one in a miniature female Pinscher and the other one in a female Poodle, both attended at the Veterinary Hospital of FMVZ/Unesp-Botucatu. The animals presented ulcerated, erythematous lesions with secretion and points of necrosis along fascial planes. Bacterial culture was positive for Streptococcus spp. The animals were treated with enrofloxacin, associated to topical cleaning of the lesions with saline solution and triclosan-based soap and rifampicin spray. Both animals presented total remission of lesions after approximately 15 days of treatment. The present report aims to alert veterinary clinicians to the severity of Streptococcus spp infections.