DUCTAL CARCINOMA IN-SITU OF THE BREAST - HISTOLOGIC CATEGORIZATION AND ITS RELATIONSHIP TO PLOIDY AND IMMUNOHISTOCHEMICAL EXPRESSION OF HORMONE RECEPTORS, P53, AND C-ERBB-2 PROTEIN

Background. Ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly since the advent of mammography. However, the natural history of these lesions remains uncertain. Ductal carcinoma in situ of the breast does not represent a single entity but a heterogeneous group with histologic and clinical differences. The histologic subtype of DCIS seems to have an influence on its biologic behavior, but there are few studies correlating subtype with biologic markers.Methods. The authors studied a consecutive series of 40 cases of DCIS and after its histologic categorization verified its relationship with ploidy using image analysis and analyzing estrogen receptor (ER), progesterone receptor (PR), p53 and c-erbB-2 expression using immunohistochemistry.Results. The three groups proposed according to the grade of malignancy were correlated significantly with some of the additional parameters studied, including aneuploidy and c-erB-2 expression. Aneuploidy was detected in 77.5% of cases of DCIS mainly in high and intermediate grade subtypes (100% and 80% vs. 35.7% in low grade) whereas immunoreactivity for c-erbB-2 was detected in 45% of cases of DCIS mainly in the high grade group. Expression of ER and PR were observed frequently in this study (63.9% and 65.7% respectively), but without correlation with the histologic subtype of DCIS, although we found a somewhat significant association between high grade DCIS and lack of ER. p53 protein expression was detected in 36.8% of these cases, but no relationship between this expression and histologic subtype or grading of DCIS was found.Conclusions. These results provide further evidence for the morphologic and biologic heterogeneity of DCIS. Besides histologic classification and nuclear grading, some biologic markers such as aneuploidy and c-erbB-2 expression constitute additional criteria of high grade of malignancy.

Image categorization through optimum path forest and visual words

Different from the first attempts to solve the image categorization problem (often based on global features), recently, several researchers have been tackling this research branch through a new vantage point - using features around locally invariant interest points and visual dictionaries. Although several advances have been done in the visual dictionaries literature in the past few years, a problem we still need to cope with is calculation of the number of representative words in the dictionary. Therefore, in this paper we introduce a new solution for automatically finding the number of visual words in an N-Way image categorization problem by means of supervised pattern classification based on optimum-path forest. © 2011 IEEE.

Com que corpo eu vou?: a beleza e a performance na construção do corpo midiático

Pós-graduação em Ciências da Motricidade - IBRC

Análise do desenvolvimento da atividade da criança em seu primeiro ano de vida

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

The Challenges of Psychology at Work in Mental Health: the drugs issue.

This article aims to show that the challenges of psychology in working with mental health in the field of drugs is traversed by both the conceptions molded by biopolitical forces (FOUCAULT) as the decadence of modern democracy (AGAMBEN), and visible features in the current treatment given in Brazil to issue of smoking (SILVA), as well as urbanistic projects such as the case of Luz district in São Paulo (LEITE & CASTRO). In this sense, it leads us to question about what is prohibited, about who actually suffers the punishment, in short, about what do we really take care when we take into account the Unheimlich (FREUD) and other social interdicts (BATAILLE).

Dançando o ritmo do preconceito: uma análise do estido waacking com o enfoque no sexo masculino

Understanding dance in all its educational aspects, creative and liberating, this of course work completion back motivating information for new studies and reflections. This study did a literature review to contextualize and detail reach the story and how it perpetuates in practice the dance style Waacking, sought the understanding of how the body is inserted in our society, made notes on the Sport Psychology regarding the topic fear and shame, and pledged to address the conflicting issues of gender and sexuality, to then be possible to develop what has been objectified. This study sought to establish whether there are national publications on the Waacking dance style and what their contributions to the Brazilian context, verifying the presence of stereotypes and prejudices to males in it are inserted. As used method, the survey was conducted in online databases having the following sites as a source of scientific academic content to nationwide: Google Scholar (like the filter to search only in Portuguese language - as the focus of the research is to gather national publications); Journals Portal CAPES / MEC; and SciELO - (Scientific Electronic Library Online). The review process took place using the categorization model, which was essential to be able to extract the information that met relevant from the criteria that have been pre-established, thus enabling the completion of this work Completion of course