4 resultados para Bram Stoker

em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"


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This paper aims to make a Postcolonial Reading of the Gothic novel Dracula, written by Bram Stoker. Most importantly, it is considered how the subaltern is silenced, and that how this silence reflects the characters responsible for the discourse construction in the book. For this purpose, the theories of three important writers of the Post-Colonialism, Edward Said, Homi Bhabha and Gayatri Chakravorty Spivak, were studied, as well as the enlightening ideas of Stephen Arata in The Occidental Tourist: Dracula and the Anxiety of Reverse Colonization. It also verified the construction of Orientalism in Stoker's work, and its constitutively hybrid and transparent characters due the speech manipulation with the ideological filter of the hegemonic power. This manipulation also characterizes the fragmentation in the work, which is an indication, among others, of modernity in Stoker's novel

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The NMDA receptor (NMDAR) channel has been proposed to function as a coincidence-detection mechanism for afferent and reentrant signals, supporting conscious perception, learning, and memory formation. In this paper we discuss the genesis of distorted perceptual states induced by subanesthetic doses of ketamine, a well-known NMDA antagonist. NMDAR blockage has been suggested to perturb perceptual processing in sensory cortex, and also to decrease GABAergic inhibition in limbic areas (leading to an increase in dopamine excitability). We propose that perceptual distortions and hallucinations induced by ketamine blocking of NMDARs are generated by alternative signaling pathways, which include increase of excitability in frontal areas, and glutamate binding to AMPA in sensory cortex prompting Ca++ entry through voltage-dependent calcium channels (VDCCs). This mechanism supports the thesis that glutamate binding to AMPA and NMDARs at sensory cortex mediates most normal perception, while binding to AMPA and activating VDCCs mediates some types of altered perceptual states. We suggest that Ca++ metabolic activity in neurons at associative and sensory cortices is an important factor in the generation of both kinds of perceptual consciousness.

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Pós-graduação em Artes - IA

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