Coenzyme Q(10) and its effects in the treatment of neurodegenerative diseases

According to clinical and pre-clinical studies, oxidative stress and its consequences may be the cause or, at least, a contributing factor, to a large number of neurodegenerative diseases. These diseases include common and debilitating disorders, characterized by progressive and irreversible loss of neurons in specific regions of the brain. The most common neurodegenerative diseases are Parkinson's disease, Huntington's disease, Alzheimer's disease and amyotrophic lateral sclerosis. Coenzyme Q(10) (CoQ(10)) has been extensively studied since its discovery in 1957. It is a component of the electron transportation chain and participates in aerobic cellular respiration, generating energy in the form of adenosine triphosphate (ATP). The property of CoQ(10) to act as an antioxidant or a pro-oxidant, suggests that it also plays an important role in the modulation of redox cellular status under physiological and pathological conditions, also performing a role in the ageing process. In several animal models of neurodegenerative diseases, CoQ(10) has shown beneficial effects in reducing disease progression. However, further studies are needed to assess the outcome and effectiveness of CoQ(10) before exposing patients to unnecessary health risks at significant costs.

Fatores que influenciam a textura da carne de novilhos Nelore e cruzados Limousin-Nelore

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Substâncias húmicas aquáticas: fracionamento molecular e caracterização de rearranjos internos após complexação com íons metálicos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Telomere length and its relationship with chronic diseases - New perspectives for periodontal research

Objective: The ageing process is accompanied by a variety of cellular modifications, and telomere shortening is a common finding. Large epidemiological studies have reported an association between shorter telomere length in peripheral leukocytes and several inflammatory diseases of the elderly including diabetes, atherosclerosis and, recently, periodontitis. The primary aim of this study was to critically discuss available evidence regarding the potential mechanisms relating shorter telomeres to periodontitis. Design: A narrative literature review was performed to report evidence relating shorter telomeres to the ageing process and inflammation. Then, we searched MEDLINE (1950 to May 2012) and ISI WEB OF SCIENCE (1950 to May 2012) databases for the combination of the terms 'telomere' and 'periodontitis'. Results: Although these associations suggest a possible role of telomere attrition in the onset or evolution of chronic inflammatory diseases, only two studies addressed the relationship between telomere length and periodontitis. Conclusion: We suggest that the chronic inflammatory burden observed in people with chronic periodontitis could represent the driver of telomere shortening. However, further evidence is needed to confirm whether inflammation is the cause or the consequence of the shorter leukocyte telomere length observed in people with periodontitis. © 2012 Elsevier Ltd. All rights reserved.

Análise clínico-histológica da queilite actínica: uma abordagem interexaminadores e correlação de áreas atróficas e não atróficas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Perfil da ingestão de alimentos e de nutrientes relacionados à saúde óssea, de mulheres com mais de 60 anos, moradoras da cidade de Bauru, São Paulo

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Caracterização da educação em saúde dos cuidadores formais em institutições de longa permanência para idosos de Botucatu-SP

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Qualidade da carne maturada de bovinos Nelore terminados em confinamento

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Posso ajudar? Cuidador formal e relação de ajuda: a percepção do idoso acerca do apoio oferecido por um serviço socioassistencial de um município do interior de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Associação entre a qualidade de vida e aspectos nutricionais na terceira idade

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Associação entre doença renal e anemia em idosos atendidos em um centro se atenção integrada a melhor idade de Manaus (AM)

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Envelhecimento e bucalidade: suas múltiplas dimensões

Pós-graduação em Odontologia Preventiva e Social - FOA

Sensory profile and acceptability of traditional and double-distilled cachaca aged in oak casks

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação da flexibilidade e dor de idosos fisicamente ativos e sedentários

Introduction: Among others things, ageing results in neuromuscular decrease. The physical activity practice may to influence positively the ageing process. Objective: To evaluate the flexibility and the level of pain on the sedentary and physically active elderly. Method: Forty-two elderly participated of this study, both male and female, (twenty-two physically active and twenty sedentary), over sixty years old and functionally capable to perform the evaluations suggested. They were submitted to tests of decrease in anterior flexion of the trunk, Stibor and Shoeber to evaluate the flexibility and then they signalized the level of pain on the analogic visual scale. The data obtained on the valuations has been analyzed utilizing the non-parametric statistic test Mann-Whitney, considering the level of significance of 5% (p<0,05), in order to compare the performance among the groups. Results: It has not been observed significant di- fferences among the groups referring to the tests Stibor and analogic visual scale. On Shoeber and FAT tests has been observed significant differences (p<0,05) among the groups, with a better performance to the active group. Conclusion: The physical activity practicing interfere on the mobility and on the flexibility of the elderly body segment.