12 resultados para 3998

em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"


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The bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging activity towards DPPH (IC50 34.4 muM and 32.7 muM, respectively) and were compared to standard compounds rutin (IC50 27.0 muM) and catechin (IC50 41.4 muM). Investigation of extracts from the seedlings roots and stems afforded one antifungal styrylpyrone: goniothalamine, and two dihydropyrones: 6-propyl-5,6-dihydro-2-pyrone and the new 6-[(4'-ethyl-9'-oxabicyclo[3.3.1]non-6'-en-3'-yl)methyl]-5,6-dihydro-2H-pyran-2-one, which had its structure determined by detailed analysis of MS and NMR data, including 2D experiments.

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Cell culture of Maytenus ilicifolia were established in order to produce and to quantify the antitumoral and antioxidant quinonemethide triterpenes. In vitro calli were induced from leaf explants of native plants and cultured in semi-solid medium under controlled conditions of humidity, temperature and photoperiod. The quinonemethide triterpenes showed maximum accumulation in the logarithmic phase growth of the cell culture. A rapid, sensitive and reliable reverse-phase HPLC method was used for quantitative determination of the antitumoral and antioxidant quinonemethide triterpenes, 22β-hydroxymaytenin and maytenin in callus of Maytenus ilicifolia. Well resolved peaks with good detection response and linearity in the range 1.0 - 100 μg/mL were obtained. This quantitative work was performed by an external standard method.

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A comparative evaluation was made of the use of natural language versus two specialized indexing languages, aiming to demonstrate the influence of the availability of indexing languages on the functioning of information retrieval systems. The study was conducted within the ambit of the construction of search strategies by subject in online university library catalogs. The precision ratio was calculated to determine the accuracy of each indexing language in subjectbased information retrieval. From the comparative evaluation of the use of indexing languages, it was concluded that the term specificity required by the user during retrieval was more satisfactory when the query was made through controlled languages, whose availability and simplicity is also an indispensable requisite.

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This study, of an instrumental nature, discusses the theoretical differences which underpin the documentary analysis models used in traditional Diplomatics and Contemporary Diplomatics. Undoubtedly, both models of analysis contribute to the understanding of the sources -a vital point of the process of analyzing the document to be used in any area. Thus, the choice of either technique must take into account the goals proposed for the research, according to the object that is taken as the reference point: the archival series or the individual document. That way, issues such as the evidential value and diplomatic authenticity are important within the Archival Science, which seeks through auxiliary disciplines to verify the historical trail of the document, from the moment of its production, usage and archiving, as well as the various custodians, contributing in a large measure to the understanding of its information -what is registered as well as the context- in its broadest sense.