Estudo fotodinâmico da clorofila a, azul de metileno e rosa bengala como agente inseticida contra Aedes aegypti

Photodynamic therapy, term introduced by von Tapeiner in 1900, can be defined as the administration of a non toxic drug, i.e., a dye, known as photosensitizer (FS), which subsequently will be illuminated with light of specific wavelength. PDT is based on the interaction among FS, oxygen and light, which through photochemical reactions cause cell death. The FS molecules must have a high probability to form the singlet state after the excitation, which can induce chemical changes in the neighborhood in two ways, called reactions type I and type II. The type II reaction is based on the exchange of energy to molecular oxygen, exciting it to its state of higher energy (singlet), which is highly reactive. The proposed mechanisms for cell death are linked to damage to the DNA, mitochondria and to the cytoplasmic membrane. Several pre‐clinical and clinical trials have been carried out and the PDT is already used in many countries for treatment mainly against certain types of cancer. The therapy also has been gaining strength in antimicrobial control, since the microorganisms have appeared increasingly resistant to current antibiotics. Another attempt to use the PDT is for the inactivation of macro‐organisms, such as micro‐crustaceans and mosquitoes. To this end I tested whether the photosensitizers methylene blue, rose Bengal and the chlorophyll a has insecticidal activity against the yellow fever and dengue vector mosquito, Aedes aegypti. Since these diseases have no effective treatments, its control is linked to the vector control, which has shown resistance to chemical pesticides used. Based on this, this work shows its importance, because it is a new type of mosquito control since all the photosensitizers used are low cost, do not generate toxic products at the concentrations used and showed good results in mortality. The best photosensitizer was rose Bengal... (Complete abstract click electronic access below)

Proposta de intervenção e gerenciamento das áreas potencialmente contaminadas: estudo dos brownfields no distrito Belém em São Paulo

In the district of Belém, at São Paulo’s city, the economic transformations have ended up destabilizing the economy industrial leaving marks that can be found today. Idle sheds, abandoned or undefined uses structures are found throughout the neighborhood, creating a scene of decay and abandonment. Despite the problems caused by brownfields, they may be seen as an area of possibilities. The reuse of these areas allows the reutilization of abandoned space in locations where the infrastructure is already available, stopping the expansion of urban spot in places not yet degraded. In the case of disabled older industries, there is a great possibility of site’s contamination that may also pose risks to people and unforeseen during refuncionalization. Therefore, the proper management of these sites is needed before any intervention in the area, where stages of study and research must be conducted in order to prove their actual situation. The survey and study of these areas in the district of Belém in São Paulo provides an overview about the brownfields in Brazil at the same time that contributes to the development of intervention plans and proposes a scenery for the refuncionalization of these sites in the neighborhood.

A noção de festa nas relações públicas: a comunicação comunitária na Feira da Vila Madalena

This paper aims to review the concept of Festival in the area of Public Relations and discuss about it according to the Classical Anthropology, Urban Anthropology and Public Relations theories, by their main exponents Emile Durkhein, Rita Amaral, Roberto Damatta and Joseph Guilherme Magnani, Waldemar Kunsch, Margarida Kunsch, Cicilia Peruzzo, Rennan Mafra and Márcio Simeone. The 33rd Vila Madalena Fair, a craft fair that takes place once a year in São Paulo, was chosen as a case study to provide this research with an empirical dimension. The Fair emerged as a result of the neighborhood residents and merchants´ mobilization in the late 70's and until today, has been responsible for the re-updating and the strengthening of the neighborhood identity. Thus, the proposal is to evaluate the possibilities of the Festival performance as a favorable strategy to sociability, to the strengthening and the re-updating the symbolic representations of a community

Ambiente percebido e sua associação com a atividade física total no lazer em adultos residentes no município de Rio Claro, SP

Introduction: Given the repercussion of the important role of physical activity in the prevention of sickness and non-communicable diseases / loss, many works have been done in order to understand the association of sociodemographic characteristics with sedentarism. The elements which influence the physical activity practice are countless. Besides the intrapersonal element, environment elements (social environment, cultural environment, public politics, information environment, natural environment etc.) are also important in the life style. Yet, the way that the person understands the environment can be considered in the planning of the strategies to change the sedentary behavior. Objective: Verify the association of the environment perception with the practice of physical activity (FA) at leisure time in adults living in Rio Claro – SP. Methodology: The sample consists of 470 adults, all residente in rio Claro-SP, aged ≥ 18 years old. The chosen participants answered to the questionnaires: Neighborhood Environmental Walkability Scale (NEWS), International Physical Activity (IPAQ) and to a specific questionnaire with personal data (age, sex, educational level, economical level, weight, height and marital status). The analysis of the connection between the variables was done through the Logistic Regression with Confidence Interval of 95%, using the software SPSS 17.0. Those who reached the recommendation of 10 minutes or more of physical activity in leisure time for week were classified as active, and those who did not reach the recommendation were classified as underactive. Results: The proportion of subjects who practiced physical activity in leisure time was 38,7%, and the male subjects, as well as those classified as better social level showed higher chances to practice at least 10 minutes weekly of physical activity during leisure. Still, walking the dog, soccer fields and gardens near the house (less than 10 walking minutes), were...

O vazio da união das culturas nipo-brasileira: projeto no bairro da Liberdade-SP

The work aims at an architectural project in the neighborhood of Liberdade in Sao Paulo, from analysis of the spread of Japanese culture in Brazil. Within this theme, the paper focuses on the Japanese urban space and the search for an identity of the Japanese, besides the problems that the neighborhood has. The architectural design is justified by the need for spaces of rest, meetings and green areas, where people can get away a bit of pace that the neighborhood has. The source of this research is based on bibliographic references, reviews of other projects, investigating the experience of urban space and the richest source of contributions that were the memories of living in Japan for eight months. The expected result is the visualization of the project through sketches, experiments and artistic designs for the chosen location

Estudo urbano e ambiental da circulação urbana do bairro de Santo Amaro, cidade de São Paulo

This work is resulted of studies about the urban circulation in the modern cities. It was developed from two case studies: the city of São Paulo, specifically Santo Amaro's neighborhood and the city of Regensburg in Germany. The urban circulation of these places was analyzed starting from the premise that the daily of the inhabitants is a relevant factor to be considered. It was researched the types of transportation, the accessibility, and the clearance of public transportations. One of the main purposes of this work was to present general guidelines for the improvement urban circulation in the modern cities, as well as to supply didactic material that contribute to the reflection about urban circulation focusing priorly on the problems of traffic of driving force vehicles

Estudo da viabilidade de implantação de um Bairro Universitário sustentável na cidade de Guaratinguetá, a partir das diretrizes para a elaboração do projeto urbanístico

This paper presents a proposal for the creation and revitalization of the IAPI neighborhood in the city of Guaratinguetá, in order to create a relationship of respect between the citizens and students Guaratinguetaenses, improving the quality of life of the entire population of the city. In addition, the presentation of the integration of educational institutions in the city's historical context is important to understand the situation in which the municipality has developed

Bioatividade de cipó-prata (Trigonia nivea Cambess) sobre a excreção renal de água e eletrólitos e pressão arterial

Brazil is a country with the largest world´s vegetal genetic diversity and the Environmental Protection Area (APA) of the “Serra da Mantiqueira” is a very heterogeneous region, representing one of the richest sources of pharmacologically actives materials. The population uses medicinal plants and according to the OMS, 80% of the population uses them in primary treatment of several diseases. Nevertheless, the loss of traditional knowledge associated with medicinal plants is occurring quickly. The ethnopharmacological strategy uses traditional knowledge to the search for medicinal plants that can have bioactive substances against diseases that afflicting the population and thus protect traditional knowledge. The “cipó-prata” (Trigonia nívea Cambess.) is a native plant normally found in the “Bacia do Paraná” region and present in the flora in the neighborhood of “Marins”, Piquete-SP and usually, said for the treatment of renal and urinary diseases. So, the objective of this study was test if the “cipóprata” (Trigonia nívea Cambess.) has effects on the renal excretion of water and salt, in anesthetized Wister rats. The tests were made in males Wistar rats and randomly distributed into 4 experimental groups: Group I – aqueous control, Group II – treated with aqueous extract (EA) of “cipó-prata”, Group III – water control + “tween 80”, Group IV – treated with ethanol extract (EE) and “cipó-prata”. All groups were subjected to experimental protocol, composed of three periods: Balance (40 minutes), Basal (30 minutes) and Experimental (90 minutes), occurring the urine collection every 30 minutes, from the basal period and measuring blood pressure every 10 minutes. The aqueous extract (EA) of “cipó-prata” (Trigonia nívea Cambess.) presented diuretic effect of 173% (B-2,4±1,19 μL/min reaching 6,6±1,45 μL/min, in the period EX3) and ...(Complete abstract click electronic access below)

Efeito de temperaturas alternadas sobre desenvolvimento de Aedes (Stegomyia) aegyoti (L.) (Diptera: Culicidae)

Aedes (Stegomyia) aegypti is a species of mosquitoes known to be the vector of diseases such as dengue and yellow fever, and a better understanding of aspects of their biology can help in the establishment of control strategies for the same. Several previous studies showed that temperature significantly affects the development of immature stages of insects. In general, higher temperatures (up to a threshold) accelerate the development of insects, and lower temperature retards the same. This rule also applies to mosquitoes, including Ae. aegypti. But not still know the effects of daily variation of temperature on the developmental stages of mosquitoes. And this detail is very important, since in natural breeding or artificial, The mosquitoes usually face temperature variations over a single day, which should interfere with its development until the emergence of the adult forms. For this reason, the objective of this study is to analyze the effect of alternating temperatures on the development of Ae. aegypti. To conduct the study, adults were collected active in the neighborhood Bela Vista Campus of UNESP - Rio Claro, SP, using a sweep net or using ovitraps for immatures, and the active search for breeding. Individuals collected were kept under experimental conditions in the laboratory. The adult samples were identified to species level, were considered for the experiments, only samples of Ae. aegypti. The insects were housed in plastic cages, suitable for creating flies. These were fed with sugar solution and blood meal on alternate days. The eggs obtained were used in the experiment with four different temperature regimes. The data collected were analyzed by evaluating whether the different treatments influenced the development of immature to adult, performing the Kruskal-Wallis test and the statistical software BioEstat. Statistical analysis of the sex ratio... (Complete abstract click electronic access below)

Proposta de criação de um Parque Natural Municipal no entorno no bairro Mãe Preta em Rio Claro - SP

This study aims to identify the environmental and social elements that should underpin the creation of a Municipal Natural Park in accordance with Law 9985/2000, establishing the SISTEMA NACIONAL DE UNIDADES DE CONSERVAÇÃO ( SNUC ) . The northeast sector of the city of Rio Claro - SP , envolving, among others , the neighborhood Mãe Preta, the most significant of the site is consolidated as an area of significant environmental value for the consolidation of a conservation area . The proposed establishment of this unit has been discussed since the beginning of this year by Secretaria Municipal de Planejamento, Desenvolvimento e Meio Ambiente de Rio Claro- SP (SEPLADEMA ) and meets the Municipal Director Plan that provides for the establishment of several protected areas in the City . The study area suffers severe pressure due to peripheral urbanization and characterized environmental fragility according to numerous studies by researchers at UNESP, Rio Claro - SP and research in situ. Stand out in soils susceptible to sheet erosion area, the presence of a large proportion of gully area subject to flooding and significant breeding capitation water for public supply

Proposta de arquitetura e protocolo para a geração automática de assinaturas de malwares

Given the exponential growth in the spread of the virus world wide web (Internet) and its increasing complexity, it is necessary to adopt more complex systems for the extraction of malware finger-prints (malware fingerprints - malicious software; is the name given to extracting unique information leading to identification of the virus, equivalent to humans, the fingerprint). The architecture and protocol proposed here aim to achieve more efficient fingerprints, using techniques that make a single fingerprint enough to compromise an entire group of viruses. This efficiency is given by the use of a hybrid approach of extracting fingerprints, taking into account the analysis of the code and the behavior of the sample, so called viruses. The main targets of this proposed system are Polymorphics and Metamorphics Malwares, given the difficulty in creating fingerprints that identify an entire family from these viruses. This difficulty is created by the use of techniques that have as their main objective compromise analysis by experts. The parameters chosen for the behavioral analysis are: File System; Records Windows; RAM Dump and API calls. As for the analysis of the code, the objective is to create, in binary virus, divisions in blocks, where it is possible to extract hashes. This technique considers the instruction there and its neighborhood, characterized as being accurate. In short, with this information is intended to predict and draw a profile of action of the virus and then create a fingerprint based on the degree of kinship between them (threshold), whose goal is to increase the ability to detect viruses that do not make part of the same family

Estudo de impacto de vizinhança: diretrizes para elaboração

This scientific research focus on the “Estudo de Impacto de Vizinhança” (EIV, Neighborhood Impact Study), a legal instrument instituted by federal law, and regulated by municipal law, that aims to evaluate the impacts in the neighborhood caused by the implantation or expansion of ventures within the urban zone. The main objective of this research was the formulation of general guidelines for EIV elaboration. Therefore, the following steps were considered: review of the legislation and literature on the theme; assessment of existing municipal legislation about this theme; assessment of EIVs elaborated within Rio Claro (SP); elaboration of the general guidelines for EIV elaboration, which were summarized in a flowchart

Narrativa e experiência: percepções, práticas culturais e memórias de pessoas migrantes

Based in the contact with adults with little education that living in two suburbs of Rio Claro-SP, whose population is largely coming from other states, there were some questions, including: What are reasons for migration are pointed in the narratives of adults little schooling participants EJA classes? So, in the first moment of this research, we present some data collected through a questionnaire applied to students of EJA, we taking information about the state and county of origin of each student. In the second stage methodology was used Oral History pointed questions about the motives of migration reported by subjects who migrated, access and search for education and practice in reading and writing. It was also realized, an activity imagery (or walker interview) with the student, highlighting elements of the landscape of the neighborhood that brings memory's birthplace. Therefore, we present here the stories of women who had migratory experience

Resolução do problema de sequenciamento de múltiplas linhas de montagem de modelos mistos em ambiente de produção enxuta

This work deals with the sequencing of Multi-Mixed-Model Assembly Lines in a lean manufacturing environment, where an operational structure where several kanbans support several mixed-model assembly lines, so that all assembly lines can receive parts or sub-assemblies from all suppliers. To optimize this system, the sequencing seeks to minimize the distance between the real consumption and the constant ideal consumption of parts or subassemblies, thereby reducing the scaling of kanbans and intermediate stocks. To solve the sequencing problems, the method Clustering Search was applied along with the metaheuristics Variable Neighborhood Search, Simulation Annealing and Iterative Local Search. Instances from the literature and generated instances were tested, thus allowing comparing the methods to each other and with other methods presented in the literature. The performance of the Clustering Search with Iterated Local Search stands out by the quality and robustness of their solutions, and mainly for its efficiency, whereas it converges to better results at a lower computational cost

Heurística especializada aplicada na alocação ótima de bancos de capacitores em sistemas de distribuição radial

Pós-graduação em Engenharia Elétrica - FEIS