Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases

Mucoadhesive tablets with different mixtures of chitosan and carbomer homopolymer type B were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling and erosion studies, ex vivo mucoadhesion force and in vitro drug release. The drug released mechanism was described by Korsmeyer-Peppas and Weibull models. Tablets containing increased amounts of chitosan presented higher swelling ability and the drug release was prolonged in the simulated saliva fluid. The mechanisms for the drug release from tablets were complex, including diffusion, swelling and erosion simultaneously. This kind of delivery system is suitable for formulating metronidazole mucoadhesive systems, representing a good alternative for the local treatment of periodontal diseases.

Preliminary diagnosis of ophtalmological diseases through machine learning techniques

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Pesticidas: uma revisão dos aspectos que envolvem esses compostos

Pesticids are chemical products used to control plagues (animal and vegetable) and plant diseases. Due to the process of automation occurred in the agriculture in 1960-1970, the agrotoxics began to be largely used in Brazil. Their physical-chemical proprieties, as well as the frequency of use, form of application, environmental biotic and abiotic characteristics and climatic conditions will determine their environmental destination. These variables will define the spectrum of environmental impacts and human health problems caused by the agrotoxics. The human health impacts might be acute or chronic, mainly upon neurological, reproductive and respiratory process. In the environment, the agrotoxics cause transformations and modifications in biota, water, soil and other ecosystems. To make farmworkers aware of alternatives to massive use of agrotoxics is the guarantee for an agriculture development more sustainable, without disorders in human health and in environment

Tobacco in adolescence: importance to knowledge the health hazards and preventive measures

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Doença cerebelar em cães e gatos

Diseases of the cerebellar system are common in small animals, and result in a clinical syndrome characterized by hypermetria, base-wide stance and intentional tremors of the head and body. All movements of the limbs are spastic and awkward. The neurological examination assists in the localization of lesions restricted to the cerebellum or in the detection of disorders relating to other parts of the nervous system, which characterizes a multifocal disease process. Neurological disorders in dogs and cats may suggest a very extensive list of differential diagnoses, since they may be caused by infectious, degenerative and traumatic processes, among others. The possible etiologies for cerebellar syndrome include: aplasia and hypoplasia, abiotrophy, cancer, vascular stroke and inflammatory disorders. The aim of this paper is to review the clinical signs that aid in the location of the cerebellar lesion and discuss the possible causes of this syndrome in dogs and cats.

Meningite supurativa secundária a otite média e interna em um gato: relato de caso

Suppurative meningitis are rarely reported in dogs and cats. The present study aims to report the occurrence of suppurative meningitis secondary to otitis media and interna in a five-year-old female Persian cat examined at the Veterinary School of Unesp-Botucatu with acute progressive multifocal neurological alterations. Analysis of the cerebrospinal fluid (CSF) demonstrated predominance of neutrophils (90%) and the presence of bacteria. Therapy with antibiotics was initiated, but the animal came to die. beta-hemolytic Staphylococcus, beta-hemolytic Streptococcus and Proteus mirabilis were detected in fragments sent to culture. The present report demonstrates the importance of performing more specific exams such as complete CSF analysis in cases of otitis media and interna. This way, central nervous infections can be diagnosed and treated in a timely manner, as those are acute diseases with poor prognosis.

Estudo retrospectivo de 1137 animais submetidos à acupuntura na FMVZ-Unesp-Botucatu-SP

The evidences of efficiency and the relation of cost-benefit of therapy are obtained with revisions developed from primary studies, which includes descriptive, analytical, retrospective and prospective. This is a retrospective survey from the Acupuncture Clinic from the Faculty of Veterinary Medicine and Animal Science, S„o Paulo State University, Botucatu, Brazil from 1998 to 2009. Acupuncture efficacy, clinical evolution, the need or not of complementary therapies to acupuncture and the patient profile were evaluated in 1137 clinical charts. The main diseases presented by attended patients involve neurological and musculoskeletal problems. The majority of the patients are dogs and presents chronic diseases or low-response to usual therapies (allopathic). This prevalence is probably due to acupuncture efficacy in disc disease. The poor compliance to acupuncture treatment can be related the patient profile: animals that did not benefit from pharmacological or surgical recommended procedures. Acupuncture was the first choice for almost half (47%) of the patients.