Diretrizes de conduta e tratamento de síndromes febris periódicas associadas à criopirina (Criopirinopatias–CAPS)

To establish guidelines based on cientific evidences for the management of cryopyrin associated periodic syndromes. The Guideline was prepared from 4 clinical questions that were structured through Pico (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 1215 articles were retrieved and evaluated by title and abstract; from these, 42 articles were selected to support the recommendations. 1. The diagnosis of Caps is based on clinical history and clinical manifestations, and later confirmed by genetic study. Caps may manifest itself in three phenotypes: FCAS (mild form), MWS (intermediate form) and Cinca (severe form). Neurological, ophthalmic, otorhinolaryngological and radiological assessments may be highly valuable in distinguishing between syndromes; 2. The genetic diagnosis with NLRP3 gene analysis must be conducted in suspected cases of Caps, i.e., individuals presenting before 20 years of age, recurrent episodes of inflammation expressed by a mild fever and urticaria; 3. Laboratory abnormalities include leukocytosis and elevated serum levels of inflammatory proteins; 4. Targeted therapies directed against interleukin-1 lead to rapid remission of symptoms in most patients. However, there are important limitations on the long-term safety. None of the three anti-IL-1β inhibitors prevents progression of bone lesions.

Diretrizes de conduta e tratamento de síndromes febris periódicas: síndrome de febre periódica, estomatite aftosa, faringite e adenite

To establish guidelines based on scientific evidence for the management of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 806 articles were retrieved and evaluated by title and abstract; from these, 32 articles were selected to support the recommendations. 1. PFAPA is a diagnosis of exclusion established on clinical grounds, and one must suspect of this problem in children with recurrent and periodic febrile episodes of unknown origin, or with recurrent tonsillitis interspersed with asymptomatic periods, especially in children in good general condition and with preservation of weight and height development; 2. Laboratory findings are nonspecific. Additional tests do not reveal pathognomonic changes; 3. The evidence supporting an indication for surgical treatment (tonsillectomy with or without adenoidectomy), is based on two non-blinded randomized clinical trials with small numbers of patients; 4. The use of prednisone at the onset of fever in patients with PFAPA proved to be an effective strategy. There is still need for more qualified evidence to support its use in patients with PFAPA; 5. Despite promising results obtained in studies with IL-1ß inhibitors, such studies are limited to a few case reports.

Guidelines for the management and treatment of periodic fever syndromes Familial Mediterranean Fever

To establish guidelines based on scientific evidence for the management of familial Mediterranean fever. The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 10,341 articles were retrieved and evaluated by title and abstract; from these, 46 articles were selected to support the recommendations. 1. The diagnosis of FMF is based on clinical manifestations, characterized by recurrent febrile episodes associated with abdominal pain, chest or arthritis of large joints; 2. FMF is a genetic disease presenting an autosomal recessive trait, caused by mutation in the MEFV gene; 3. Laboratory tests are not specific, demonstrating high serum levels of inflammatory proteins in the acute phase of the disease, but also often showing high levels even between attacks. SAA serum levels may be especially useful in monitoring the effectiveness of treatment; 4. The therapy of choice is colchicine; this drug has proven effectiveness in preventing acute inflammatory episodes and progression towards amyloidosis in adults; 5. Based on the available information, the use of biological drugs appears to be an alternative for patients with FMF who do not respond or are intolerant to therapy with colchicine.

Apoptose no carcinoma de próstata

Pós-graduação em Patologia - FMB

O uso do acervo do Programa Nacional Biblioteca da Escola em uma perspectiva inclusiva

Pós-graduação em Educação - FCT

Radiopacity evaluation of contemporary luting cements by digitization of images

The aim of this study was to evaluate the radiopacity of two conventional cements (Zinc Cement and Ketac Cem Easymix), one resin-modified glass ionomer cement (RelyX Luting 2) and six resin cements (Multilink, Bistite II DC, RelyX ARC, Fill Magic Dual Cement, Enforce and Panavia F) by digitization of images. Methods. Five disc-shaped specimens (10×1.0 mm) were made for each material, according to ISO 4049. After setting of the cements, radiographs were made using occlusal films and a graduated aluminum stepwedge varying from 1.0 to 16 mm in thickness. The radiographs were digitized, and the radiopacity of the cements was compared with the aluminum stepwedge using the software VIXWIN-2000. Data (mmAl) were submitted to one-way ANOVA and Tukey's test (=0.05). Results. The Zinc Cement was the most radiopaque material tested (<0.05). The resin cements presented higher radiopacity (<0.05) than the conventional (Ketac Cem Easymix) or resin-modified glass ionomer (RelyX Luting 2) cements, except for the Fill Magic Dual Cement and Enforce. The Multilink presented the highest radiopacity (<0.05) among the resin cements. Conclusion. The glass ionomer-based cements (Ketac Cem Easymix and RelyX Luting 2) and the resin cements (Fill Magic Dual Cement and Enforce) showed lower radiopacity values than the minimum recommended by the ISO standard.

Curso de capacitação para líderes, voluntários, profissionais e gestores de comunidades terapêuticas: o conhecimento em relação ao álcool, crack e outras drogas

Pós-graduação em Saúde Coletiva - FMB

Análise da proteína EGFR em carcinoma espinocelular de lábio

Pós-graduação em Biopatologia Bucal - ICT

La relacion entre la calidad de la ensenanza y mala prática odontológica: relato de un caso clínico

The activities developed in health area are of great importance, because they have the aim to preserve the life of the men, and therefore, must be performed by authorized persons. The increase of the number of dental schools, the decline at the education quality and a higher admission of students with low ability to exercise their profession, are facts that bring disastrous consequences for society. These facts are, also, reflected at the moral, ethical and technical-scientific performance of the professional. The purpose of this clinic case is to show that although there is a significant suplly of education institutions, there is a lack of scientific and adequate technical knowledgement from the graduated dentals surgeons. The patient MSL, 17 year old, female, went to a dental clinic presenting a tray type Vernis, attached to the lower arch. After clinical evaluation, it was showed that an incorrect material was used for the impression technique, being impossible to take out the tray by the conventional manner. The planning for the removal of the tray was through the divide of it. Thus, the consequence of the lack of knowledge in the use of impression materials had caused a great incovinience to the patient. It can be concluded that the rate of malpractice is directly related to the professional preparation, highlighting the importance of quality dental education for a responsible clinical practice.

Saúde do trabalhador na odontologia: o cirurgião-dentista em foco

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Brazilian dentistry profiles and workforce

The aim of this study was to assess the dentistry profile, based on social and demographic data, post-graduation formation, and to verify the insertion of dental graduates in the labour force. The participants were professionals graduated from a Brazilian Public Dental School, between 2000 and 2010. An instrument was sent by mail and/or e-mail to them. It was used Kruskal Wallis Test. Among 1047 questionnaires, 189 returned and 65.6% were answered by female. In relation to post-graduation course, 57.7% of professionals performed it, however 56.9% not attended only in their area; 66.6% of professionals are concentrated in cities larger than 100 thousand habitants. There was association between income and gender, and others. The predominant work modality was self-employed. Among the total, 36.5% want to work part-time in dentistry. The female gender was predominant and there was wage discrepancy between genders. The professionals have been concentrated in largest cities.

O conceito de saúde geral e bucal na visão dos cuidadores de idosos

The aim of this study was to analyze the perception of elderly caregivers in relation to the meaning of general and oral health and about oral health status of the institutionalized aged. It was performed a qualitative study, using Discourse of Collective Subject method. It were interviewed 42 caregivers who worked in longterm care facilities of Araçatuba City, SP and Passo Fundo City, RS – Brazil, applying a structured questionnaire. The interviews were recorded and transcript to be performed the qualitative analysis. The answers were analyzed and them it was elaborated the discourses of collective subject (DCS). Oral health, according to caregivers, was hygiene habits and good diet, while the absence of oral health was sequelae of oral diseases. It's possible to note that older means of health were being substituted by new perceptions of quality of life and is very divergent between older professionals and those who graduated during last two decades. However, according to caregivers, this health perception as quality of life was not included in Dentistry, where the old mean "absence of symptoms" was prevalent. For part of them, the institutionalized elderly have no oral health and the only way to improve their condition was through clinical attendance.

Aspectos sociodemográficos e epidemiológicos dos casos de hanseníase em uma área endêmica: conhecimentos e experiências de cirurgiões-dentistas

Pós-graduação em Odontologia Preventiva e Social - FOA

O renascer da pós-graduação em poéticas visuais na UNESP, campus de Bauru: contribuição valiosa para os cursos de artes

The postgraduation program in Visual Poetics, Master level, to be started in 2011 at the faculty of Architecture, Arts and Communication of the state university of São Paulo "Julio de Mesquita Filho"- Bauru Campus, arises strong and well structured contributing to the strengthening of Arts courses. It is noteworthy that the Visual Poetics area has graduated in its previously existing program, more than 30 (Thirty) masters and 8 (eight) doctors. They are currently linked to state and federal universities of Sao Paulo, Parana, Santa Catarina and Mato Grosso do Sul . Ricardo Nicola is Post-Doctor by IES since 2007: University of Toronto, Canada, is presented as mentor and coordinator of the renaissance process of masters program in Visual Poetics.Nelyse Apparecida Malro Salzedas , graduated as a Professor in 1993 at the same University, she has contributed significantly to the Program implementation and will be vice-coordinator of the project.

Concepções de professores sobre gestão escolar

This study examined the newly graduated in pedagogy teachers' perceptions of current school administration concepts and practices. It is an exploratory research study with questionnaire using Likert scale closed-ended questions. The results indicate an emphasis on the official view of the school administration and the sharing of responsibilities as a democratic basis. It is concluded that the respondents have basic perceptions, little criticism on the school administration, reproducing, often a government and media discourse on the subject.