In Vitro Regulation of CCL3 and CXCL12 by Bacterial By-products Is Dependent on Site of Origin of Human Oral Fibroblasts

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The role of IL-6 on apical periodontitis: a systematic review

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Functional traits of selected mangrove species in Brazil as biological indicators of different environmental conditions

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estrutura, composição florística e caracterização sucessional em remanescente de Floresta Estacional Semidecidual no Sudeste do Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação quantitativa do uso dos recursos hídricos em unidade de conservação e entorno: estudo de caso do Parque Estadual da Serra do Mar

Pós-graduação em Engenharia Civil e Ambiental - FEB

Photoperiod modulation of aggressive behavior is independent of androgens in a tropical cichlid fish

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Classificação dos jogos no ambiente virtual do lazer, na perspectiva de usuários

Esse estudo, de natureza qualitativa, objetivou investigar as diferentes classificações dos jogos virtuais e os mais procurados pelos usuários. A pesquisa foi composta pela união de pesquisas bibliográficas e exploratórias, desenvolvida por intermédio de questionário semi-estruturado, aplicado a usuários de jogos virtuais on-line, participantes de fóruns on-line do Brasil. Os dados foram analisados descritivamente. Dos 17 indivíduos que responderam à pesquisa, 82% são do sexo masculino e 18%, do sexo feminino, com idades entre 21 e 27 anos. O lugar que em que mais acessam os jogos virtuais são suas casas, e a maior freqüência de acesso é de 7 dias por semana (29%), de 3 a 5 horas por dia (76%). O principal interesse pelos games acontece por esses serem uma forma de entretenimento. Dentre os jogos mais citados como seus favoritos estão Metal Gear Solid, Resident Evil, Farmville, Age of Empires e The Legend of Zelda. Quando perguntados o porquê de seu interesse por tal jogo, os participantes responderam que eles promovem socialização, diversão, contém gráficos (imagens e sons) e enredos interessantes, entre outros. A categoria de jogos favorita dos participantes é a de tiro (First Person Shooter), com 35% de citações, seguida por jogos de esportes, com 30%; porém, 23,5% respondeu não ter preferência quanto à categoria do game. Quanto à Classificação Indicativa, 65% dos participantes a consideram um fator importante, enquanto 35% consideram-na desnecessária. Porém, 88% responderam não olhar a Classificação Indicativa do game antes de comprá-lo ou utilizá-lo, citando, dentre os principais fatores, não se importarem ou ofenderem com qualquer conteúdo que o jogo possa apresentar e por serem maiores de idade.

Estudo sobre o entorno do mercado municipal de São Paulo

A city is a place, is a housing, is the birthing place of economics. A city is made of routes, is made of people, by people and must also be structured for people. However, with the consolidation of a neoliberal economic system where ownership and economic generation prevail over the citizen's rights and the needs of those who have less, the city becomes a space of buying, exchange and increasingly commercial. The city of São Paulo is part of this context and is the result of the transformation process driven by real estate speculation, and the presented study area, the surroundings of the Municipal Market of São Paulo, is a new area in transformation. This work has the goal to bring a historical perspective and current status of the locality, with their revitalization projects, landscape changes and changes in housing, audience and resident citizens

Avaliação da qualidade de vida através do indicativo de saúde no bairro jardim Cherveson em Rio Claro-SP

This research reffers to a study of case about Jardim Cherveson district, in which was mensured the quality of life of the resident population. The term quality of life has a dificult definition, because include a lot of variables objectives and subjectives, however, we can say that good quality of life depends on health condition of the individual. To assess the quality of life of the residents on district were verified the diseases of higher occurrence, identifing if the same were caused by the condition of local urban infrastructure and still the treatment of the Unidade Básica de Saúde in the study area

Associação da ocorrência de formigas (Hymenoptera: Formicidae) com atributos do solo e da vegetação em um domínio do cerrado à nordeste do estado do maranhão, Brasil

Pós-graduação em Agronomia (Ciência do Solo) - FCAV

Evidência da presença do sistema AGR, expressão de toxinas e resistência aos antimicrobianos em estafilococos coagulase-negativa isolados de hemoculturas

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Prostituição e morte em Maggie: a girl of the streets: uma leitura feminista sobre a Slum fiction norte-americana de Stephen Crane

Pós-graduação em Letras - FCLAS

RANKL expression is differentially modulated by TLR2 and TLR4 signaling in fibroblasts and osteoblasts

Resident, non-immune cells express various pattern-recognition receptors and produce inflammatory cytokines in response to microbial antigens, during the innate immune response. Alveolar bone resorption is the hallmark of destructive periodontitis and it is caused by the host response to bacteria and their mediators present on the biofilm. The balance between the expression levels of receptor activator of nuclear factorkappa B ligand (RANKL) and osteoprotegerin (OPG) is pivotal for osteoclast differentiation and activity and has been implicated in the progression of bone loss in periodontitis. To assess the contribution of resident cells to the bone resorption mediated by innate immune signaling, we stimulated fibroblasts and osteoblastic cells with LPS from. Escherichia coli (TLR4 agonist), Porphyromonas gingivalis (TLR2 and -4 agonist), and interleukin-1 beta (as a control for cytokine signaling through Toll/IL-1receptor domain) in time-response experiments. Expression of RANKL and OPG mRNA was studied by RT-PCR, whereas the production of RANKL protein and the activation of p38 MAPK and NF-kB signaling pathways were analyzed by western blot. We used biochemical inhibitors to assess the relative contribution of p38 MAPK and NF-kB signaling to the expression of RANKL and OPG induced by TLR2, -4 and IL1β in these cells. Both p38 MAPK and NFkB pathways were activated by these stimuli in fibroblasts and osteoblasts, but the kinetics of this activation varied in each cell type and with the nature of the stimulation. E. coli LPS was a stronger inducer of RANKL mRNA in fibroblasts, whereas LPS from P. gingivalis downregulated RANKL mRNA in periodontal ligament cells but increased its expression in osteoblasts. IL-1β induced RANKL in both cell types and without a marked effect on OPG expression. p38 MAPK was more relevant than NF-kB for the expression of RANKL and OPG in these cell types.

Lesbianidades e as referências legitimadoras da sexualidade

This article is part of a master's degree dissertation that studied the way as stigmas and stereotypes regarding lesbianity influence the life, in the sphere of the sexuality, of women that denominate themselves as lesbians, resident in a city in the interior of the State of São Paulo. The stigma here analyzed is that lesbians are women that frustrated with men. We tried to show, through the narratives of the research s participants and basing on gender and feminist studies, how the heteronormativist system naturalizes the masculinity to the men and the sexuality in the masculinity, and how it legitimates speeches about lesbian woman through the heterosexual referential. Also, we tried to show some strategies of the biopoder for the maintenance of that system and, starting from interviews in depth, we presented how the participants of the research (lesbian women) make speeches on that stigma and how they re-significate it through their own narratives. That research was financed by Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP, and accomplished by the Pos-Graduation Program of the Universidade Estadual Paulista Campus of Assis-SP.Key words: Gender. Sexuality. Lesbianity. Heteronormativity.

Outbreak control and clinical, pathological, and epidemiological aspects and molecular characterization of a bovine herpesvirus type 5 on a feedlot farm in S(a)over-tildeo Paulo State

This paper describes the control, epidemiological, pathological, and molecular aspects of an outbreak of meningoencephalitis in calves due to bovine herpesvirus 5 at a feedlot with 540 animals in Sa (a) over tildeo Paulo State, Brazil. The introduction of new animals and contact between the resident animals and the introduced ones were most likely responsible for virus transmission. Bovine herpesvirus 1 vaccine was used, resulting in the efficacy of the outbreak control, although two bovine herpesvirus 1 positive animals, vaccinated and revaccinated, presented meningoencephalitis, thereby characterizing vaccinal failure.