Aplicações de redes neurais e neuro fuzzy em engenharia biomédica e agronomia

Pós-graduação em Engenharia Elétrica - FEIS

Atendimento antirrábico humano pós-exposição: proposta de intervenção e estudo da percepção do comportamento de cães e gatos envolvidos nos agravos

Pós-graduação em Medicina Veterinária - FCAV

Determinantes genéticos, bioquímicos e clínicos na resposta ao uso de hidroxiureia na doença falciforme

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Association between pharyngeal residue and posterior oral spillage with penetration and aspiration in Stroke

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Modelo de Análise e Prevenção de Acidentes - MAPA: ferramenta para a vigilância em Saúde do trabalhador

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Ingestão Oral e Grau de Comprometimento da Disfagia Orofaríngea Neurogênica Pré e Pós-Fonoterapia

Objective. To compare, pre- and post-swallowing therapy, the level of oral intake scale, and the degree of severity of neurogenic oropharyngeal dysphagia. Method. 19 patients with oropharyngeal dysphagia: 10 Post-Stroke adults, aged from 44 years to 76 years (group 1 – G1), and nine children with Cerebral Palsy, aged from two years and five months to 15 years (group 2 – G2). We excluded individuals in the process of spontaneous recovery. We held retrospective analysis of clinical protocols for clinical speech therapy evaluation with classification of the degree of dysphagia severity, applied before and after swallowing therapy. We used the Functional Oral Intake Scale - FOIS to assess the level of oral ingestion, pre and post-swallowing therapy. Results. The degree of commitment of dysphagia was favorable change only in adults, and in FOIS these changes occurred in both groups. Conclusion. There were favorable changes in the degree of impairment of oropharyngeal dysphagia and levels of FOIS, pre and post - speech therapy in stroke, but in ECINP markers used showed no favorable changes should even be reviewed for application in this population. Future studies are needed to investigate the variables in this sample.

Variabilidade da frequencia cardíaca em fase crônica de lesão cerebrovascular

The stroke, cause of morbidity and mortality, has been associated with imbalance in the neural control of the heart, which contributes to the decrease in heart rate variability (HRV) and a prognostic factor for cardiacevents and arrhythmias. The aim of this study was to in investigate the autonomic modulation of heart rate of men suffering from lesions stroke in chronicphase. Eight menaged 58.62 ± 2.88 years, 27.41 ± 5.33 kg/m2of bodymass índex, with paresis for at least six months were studied. Heart rate (HR) and RR intervals (iR-R) were recorded at rest in supine position for 10 minutes. Geometric índices of the Poincaré plot were calculated: SD1, associatedwith vagal activity; SD2, associated with global activity but sympathetic predominance, and the relationship of both (SD1/SD2). Geometric index values in the sample: SD1 = 20,54 ± 9,90ms; SD2 = 36,80 ± 30,61ms; SD1/SD2 = 0,49 ± 0,04. The reference values from literature for healthy subjects are: SD1 = 19.6 ± 9.4ms e 22.8 ± 16.1 ms; SD2 = 43.2 ± 17.7 ms e 56.3 ± 12.3 ms; SD1/SD2 = 0.49 ± 0.21ms. Men in chronic phase of stroke haven't autonomic dysfunction analyzed by nonlinear method – Poincaré geometricíndices.

Correlação entre equilíbrio, assimetria de passos e descarga de peso em indivíduos hemiparéticos

Introduction: Hemiparesis is the most common sequels after Stroke. One of the side effects of the motor skills evident in hemiparesis is the tendency to remain in asymmetric posture, with lower distribution of weight on the side hemiparetic, which ends up leading to a deficit in balance. This set of changes can cause an asymmetrical type of gait, marked by difference between the lengths of the steps these individuals. Objective: The purpose of this study was to analyze the balance, the discharge of weight in the lower limbs and asymmetry of steps in hemiparetic individuals and sees if there is correlation between those variables. Method: A group of 12 hemiparetic individuals (55,33 ± 8,92 years), both sex, who suffered from strokes participated. All subjects performed the assessment of bilateral discharge of weight, the length of the steps and balance (Berg Balance Scale). The results for the difference in the discharge of weight of the lower limbs, asymmetry of the step and the performance on the test of balance were analyzed using the Sperman Correlation Coefficient with a significance level of 5% (p ≤ 0.05). Results: We found a significant correlation between balance and asymmetry of the steps (R = -0.72 and p = 0007), however, found no significant correlation between discharge of weight on each leg and the symmetry of the steps (R =- 0.07 and p = 0, 81) and between discharge of weight and balance (R =- 0.08 and p = 0.79) in these hemiparetic individuals. Conclusion: Can be conclude that hemiparetic individuals of these study show deficits in balance, difference in weight between the discharge of the lower limbs and asymmetry of step and correlation between the asymmetry of the step and balance.

Influência da manobra de descompressão abrupta em pacientes neurológicos

A fisioterapia respiratória em pacientes neurológicos deve ser realizada com critérios e monitorização dos parâmetros hemodinâmicos. O objetivo deste estudo foi avaliar se a fisioterapia respiratória tem efeitos na pressão arterial, pulso e saturação de oxigênio de pacientes neurológicos. Estudamos 12 pacientes com acidente vascular encefálico ou trauma crânio encefálico, independente da idade, divididos em grupos: respiração espontânea (G1) e ventilação mecânica (G2). E as variáveis foram avaliadas antes (M1) e após (M2) a Manobra de descompressão abrupta (MDA). Foram estudadas a Pressão Arterial (PA), Saturação de Oxigênio (SatO2) e Pulso (P). Na estatística foi utilizado o teste t-Student (p < 0,05). Dos pacientes estudados 9 eram do sexo masculino e 3 feminino. As variáveis em G1 e G2 não variaram de forma significativa nos momentos de estudo. Concluímos que a manobra de descompressão abrupta aplicada em pacientes neurológicos não alterou as variáveis hemodinâmicas e de troca.

Redução dos riscos de operação na montagem de mancais em cilindros de laminação em uma usina siderúrgica

The increasing concerns about the health and safety is significantly changing the costeffective management of labor, also becoming an important tool in the pursuit of quality. In this context the present work makes a studyin a steel mill, to determine an action plan with the goal of reducing the risk of injury during handling and setting up bearings in a workshop of rolling mill rolls. The study is structured through the Method of Analysis and Troubleshooting, and quality tools. The definition of the action plan has brought lowcost measures that seek to solve the problem, eliminating the possibility of fatality or inability to employees

Reflexão sobre prevenção de acidentes à criança no âmbito doméstico

The aim was to reflect what action to prevent accidents used by caregivers / participants in the home. This is a prospecive cross-sectional descriptive study conducted at the Pediatric Inpatient Unit, Hospital of the Medical School of Botucatu – Unesp, during the months from May to August 2010.A questionnaire was used in the form of check list (Annex I) on measures to prevent accidents. The participant chose two alternatives taking into consideration the order of priority in the prevention of accidents. This study shows that for the age group from 29 days to 2 years, the companions chose these preventive measures for falls, burns, poisoning and drowning, “do not put near the windows mobile” (27.8%), “no access the match, lighter and appliances (22.2%), leave toxic substances out of reach and sight of children (41.7%) and empty buckets, tubs and pools after use (27.8% ). Regarding the age group 2-6 years, the measures for these types of accidents were not put near the windows mobile (26.5%), do not have access to matches, lighters and household appliances (20.9% ), leave toxic products out of reach and sight of children (27.9%) and maintain tanks, tanks and wells or struck with some protection (20.2%). For ages 6 to 10 years, the measures chosen to more such accidents were dry liquid spilled on the ground (23.5%), do not have access to matches, lighters and household appliances (22.5% ), leave toxic products out of reach and sight of children (31%) and keep tanks, tanks and wells or struck with some protection (23.5%). One fact that attracted our attention was that the preventive measures most frequently used by caregivers, regardless of age, show results that differ in few alternatives. It is essential to the understanding of the escorts / participants on the importance of injury prevention. Even today is predominantly defined as accident, injury must be addressed through measures

Estudos estruturais por difração de raios X de fosfolipases A2 em presença de íons com importância funcional

Snakes from Bothrops genus are responsible for more than 90% of the ophidian accidents in Brazil. One of the main complications from this kind of accident is muscular necrosis, which is related to the action of phospholipases A2 and metalloproteases, two groups of enzymes found in the venom of these animals. Although this complication cannot be solved by serum therapy administration, a great number of studies have been performed with the attempt to know the pharmacological sites of these toxins aiming, in the future, the development of complementary treatments to serum therapy. This work proposes structural studies of bothropic phospholipases A2 (PLA2s) in the presence of ions relevant to their activity, using the X-ray crystallography technique. Recently, it was demonstrated ions, as manganese, calcium and others, interfere in the biological activity of the PLA2s. Particularly, Lys49-PLA2s in the presence of manganese ions have miotoxicity reduced. Asp49-PLA2s show catalytic activity dependent of calcium, although structural studies with a miotoxic Asp49-PLA2, BthTX-II, suggest a possible catalytic mechanism independent of calcium. Therefore, co-crystallization of BthTX-II in the presence of calcium ions and of PrTX-I in the presence of manganese ions were performed. Comparative structural studies among obtained results and others already published in the literature were performed aiming a better understanding of the structure-function relationship of these toxins. The BthTX-II with the presence of calcium do not show this ion in the loop of coordination of calcium, presence necessary to develop the catalyses. After comparison of this model with the native one, only one distortion was found, but no apparent relationship with the residues responsible for its activity. In the PrTX-I structure, regions candidates of manganese ions were also found... (Complete abstract click electronic access below)

Radiocronologia dos sedimentos do Lago de Constança

The dating of sediments in lakes, estuaries and rivers through radionuclides, when applied in association with other analitic methods (heavy metals, organic contaminants, etc.) allows analyses of the anthropogenic interference in the environment along the years. A geochronology of a sediment core from Untersee in Lake Constance, one of the most important hydric resources of Europe, was established through the Pb-210 method and adopting the CRS parameter (Constant Rate of Supply). The Cs-137 was successfully used to give basis to the results, as its additional input occurred in Chernobyl’s accident can be used as a marker to the year 1986. Associating the dating with the cores depth, the average mass accumulation rate and the sedimentation rate for the site were assessed (0,14 g/cm²/year and 4 mm/year respectively).

Perfil do estilo de vida e conhecimento dos fatores de risco para doenças e agravos não transmissíveis em praticantes de atividade física em UBS de Rio Claro

Introdução: As Doenças Crônicas Não Transmissíveis (DANTS) são um grupo de enfermidades cujo processo de instalação no organismo geralmente se inicia com alterações, a prevenção dessas afecções tem sido um grande desafio para a saúde pública. As principais DANTS são: câncer, doenças do coração (angina e infarto do miocárdio), doenças do pulmão (como enfisema, bronquite e asma), doenças da circulação como acidente vascular cerebral e hipertensão arterial, doenças metabólicas como diabetes, hipercolesterolemia, a obesidade, relacionadas com condições de vida (como o estresse, depressão e ansiedade). Existem inúmeros Fatores de Risco (FR) relacionados a estes tipos de doenças, cuja remoção, ou atenuação, pode contribuir para o declínio da mortalidade.Objetivo: Associar comportamentos e conhecimentos de FR para doenças e agravos não transmissíveis de mulheres praticantes de AF através do projeto Saúde Ativa Rio Claro, este visa desenvolver e difundir práticas de intervenção cientificamente orientadas que incorporem a AF como parte integrante de um hábito de vida saudável para todas as pessoas. Metodologia: Participaram do estudo 100 mulheres, com idade média de 57,7((± 13,1), foram aplicados dois questionários, sendo o primeiro sobre conhecimento de FR para DANTS e o segundo avaliou comportamentos relacionados ao estilo de vida: nível de AF, consumo de álcool, dieta, taxa de colesterol, nível de estresse, tabagismo.Resultados e Discussão: Não houve associação entre conhecimento e comportamento, o conhecimento isoladamente não foi suficiente para promover modificações no comportamento das pessoas. A analise estatística utilizada foi o Qui Quadrado (x²) de 1 grau de liberdade e com nível de significância de p= 0,05. Conclusão: Um grupo de pessoas pode conhecer os benefícios de um comportamento e não ter tempo ou recursos suficientes...(Resumo completo, clicar acesso eletrônico abaixo)

Estudos estruturais e cristalização de complexos formados entre toxinas botrópicas e inibidores vegetais

This research presents a study of structural complexes formed between the bothropstoxin BthTX-I and PrTX-I and phospholipase A2 (PLA2s) inhibitor 12- methoxy-4-methyl-voachalotine (MMV) of Tabernamontana catharinensis and rosmarinic acid (Cv-RA) of Rosmarinus officinalis. For both were used cocrystallization experiments with the toxins and inhibitors. In the future, the experimental three-dimensional structures of these complexes will be obtained through the technique of crystallography. Simultaneously, construction occurred in silico of inhibitors Cv-RA and MMV and attempts of docking between these binders and protein structures. These theoretical data provide important information regarding the nature of interactions between inhibitors, toxins and structural changes induced by the protein molecule inhibitors. Therefore, the acquisition of this information has great value to identification, characterization and development (drug design) of compounds with great potential for biotechnology and drug use. Considering further and more relevant aplications, these compounds could be used to control symptoms in many cases of ophidic poisoning and also in combating of pathological processes (degenerative inflammatory diseases and auto-immune diseases, Alzheimer's disease, schizophrenia, among others) whose causes are related to molecules belonging to the same groups of proteins which are classified bothropstoxin that were studied in this project