Validation of analytical methodology for quantification of cefazolin sodium pharmaceutical dosage form by high performance liquid chromatography to be applied for quality control in pharmaceutical industry

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Multivariate Development and Validation of a Stability-Indicating HPLC Method for the Determination of Glimepiride in Tablets

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Theoretical Analysis and Experimental Validation of the Scholte Wave Propagation in Immersed Plates for the Characterization of Viscous Fluids

This work reports the study of an attractive interfacial wave for application in ultrasonic NDE techniques for inspection and fluid characterization. This wave, called quasi-Scholte mode, is a kind of flexural wave in a plate in contact with a fluid which presents a good sensitivity to the fluid properties. In order to explore this feature, the phase velocity curve of quasi-Scholte mode is experimentally measured in a plate in contact with a viscous fluid, showing a good agreement with theory.

Translation, cross-cultural adaptation and validation of the Portuguese version of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis

Translation, cross-cultural adaptation and validation of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis. The original English version of the DYMUS was translated using the forward-backward technique, cross-culturally adaptated, pilot-tested in 40 patients, and then applied to 100 multiple sclerosis patients to assess the reliability and construct validity. Construct validity was assessed by Mann–Whitney test and Spearman’s correlation coefficient (rs). The internal consistency of the questionnaire was evaluated using Cronbach’s alpha coefficient and inter-item correlation. DYMUS-BR internal consistency was high (Cronbach’s alpha= 0.72); Cronbach’s alpha was 0.65 for the ‘dysphagia for solids’ subscale and 0.67 for the ‘dysphagia for liquids’ subscale and positive inter-item correlations was found between all items, except for weight loss question. Significant association (p<0.001) and correlation (rs = 0,357; p = 0.01) was found between DYMUS-BR and dysphagia self-assessment. The DYMUS-BR questionnaire maintained the characteristics of that originally described, demonstrating to be a reliable, valid, easy and consistent tool to be used by health professionals for preliminary selection of Brazilian MS patients who need more specific instrumental analyses of swallowing.

A method for calculating the compliance of bonded-interfaces under shrinkage: Validation for Class I cavities

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Development of a knowledge-based system for cogeneration plant design: Verification, validation and lessons learned

This paper presents the development of a knowledge-based system (KBS) prototype able to design natural gas cogeneration plants, demonstrating new features for this field. The design of such power plants represents a synthesis problem, subject to thermodynamic constraints that include the location and sizing of components. The project was developed in partnership with the major Brazilian gas and oil company, and involved interaction with an external consultant as well as an interdisciplinary team. The paper focuses on validation and lessons learned, concentrating on important aspects such as the generation of alternative configuration schemes, breadth of each scheme description created by the system, and its module to support economic feasibility analysis. (C) 2014 Elsevier B.V. All rights reserved.

Method validation using weighted linear regression models for quantification of UV filters in water samples

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Reconstruction of the gravitational wave signal h(t) during the Virgo science runs and independent validation with a photon calibrator

The Virgo detector is a kilometer-scale interferometer for gravitational wave detection located near Pisa (Italy). About 13 months of data were accumulated during four science runs (VSR1, VSR2, VSR3 and VSR4) between May 2007 and September 2011, with increasing sensitivity. In this paper, the method used to reconstruct, in the range 10 Hz-10 kHz, the gravitational wave strain time series h(t) from the detector signals is described. The standard consistency checks of the reconstruction are discussed and used to estimate the systematic uncertainties of the h(t) signal as a function of frequency. Finally, an independent setup, the photon calibrator, is described and used to validate the reconstructed h(t) signal and the associated uncertainties. The systematic uncertainties of the h(t) time series are estimated to be 8% in amplitude. The uncertainty of the phase of h(t) is 50 mrad at 10 Hz with a frequency dependence following a delay of 8 mu s at high frequency. A bias lower than 4 mu s and depending on the sky direction of the GW is also present.

Inverse Modeling of GPS Multipath for Snow Depth Estimation-Part II: Application and Validation

GPS multipath reflectometry (GPS-MR) is a technique that uses geodetic quality GPS receivers to estimate snow depth. The accuracy and precision of GPS-MR retrievals are evaluated at three different sites: grasslands, alpine, and forested. The assessment yields a correlation of 0.98 and an rms error of 6-8 cm for observed snow depths of up to 2.5 m. GPS-MR underestimates in situ snow depth by 10%-15% at these three sites, although the validation methods do not measure the same footprint as GPS-MR.

Validation of the UNESP-Botucatu unidimensional composite pain scale for assessing postoperative pain in cattle

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The performance of conventional and fluorescence-based methods for occlusal caries detection: an in vivo study with histological validation

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

Validation of the weight concerns scale applied to brazilian university students

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Validation of the Geriatric Oral Health Assessment Index in complete denture wearers

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)