Uma revisão sobre o uso de medicamentos naturais para tratamento de tumores

This study objective was to review a selection of publications on the treatment of benign and malignant tumors with the use of natural medicines obtained from terrestrial and marine flora, both for use in chemotherapy and photodynamic therapy. There are many medications already being used for this purpose and many are still being tested in vivo and in vitro, but all with great future prospects for inclusion in the market

Uso de rastreadores de eventos adversos a medicamentos para farmacovigilância no âmbito hospitalar

Eventos adversos a medicamentos (EAM) ainda são uma das principais limitações nos serviços de cuidados com a saúde, causando risco aos pacientes, além de grande impacto econômico. Assim, fazem-se necessários métodos de identificação de eventos adversos mais eficazes que a tradicional notificação espontânea, a qual revela apenas 5% do total de eventos. A utilização de critérios rastreadores (ou trigger tools), elaborados pelo Institute for Healthcare Improvement, tem se mostrado como a alternativa mais válida e eficiente para a triagem dos EAM. Com o objetivo principal de identificar os principais eventos adversos e medicamentos envolvidos, uma seleção de três critérios rastreadores foi utilizada, a saber: INR (razão normalizada internacional) > 6, WBC (contagem de leucócitos) < 3000/mm³ ou registros de episódios de sedação excessiva, letargia ou queda. Informações sobre os rastreadores foram coletadas e analisadas a partir dos prontuários de pacientes internados no Hospital Estadual Américo Brasiliense internados, de novembro de 2011 a janeiro de 2012 e maio a julho de 2012, a fim de se confirmar a ocorrência de evento adverso. Foram analisados prontuários referentes a 3318 hospitalizações, nas quais foram detectados 69 eventos adversos, 49 dos quais foram causados por apenas quatro das 12 classes de medicamentos envolvidos em algum EAM: anticoagulantes orais, relacionados ao rastreador INR>6 (eficácia = 0,75), sedativos e antipsicóticos, relacionados ao rastreador de sedação excessiva, letargia ou queda (eficácia = 0,52), e antivirais, relacionados ao rastreador WBC<3000 (eficácia = 0,48). Quando os rastreadores eram acionados e não estavam relacionados a EAM, os fatores de confusão mais recorrentes foram: torpor secundário ao quadro clínico, acidentes não relacionados ao medicamento e pacientes propositalmente em regime de sedação. Apesar de valores-limite menos radicais poderem aumentar a ...

A indústria farmacêutica no Brasil: um estudo do impacto socioeconômico dos medicamentos genéricos

Recently, some countries outside the Triad (Japan, Europe and the United States) have assumed an important role in the pharmaceutical scenario, as large producers, among them stand out Brazil. In the 90s, there were major institutional transformations and the pharmaceutical industry has undergone a reverse specialization process, because liberalization has discouraged production of pharmaceutical chemicals and dependence of imports increased. The law of generics medicines in 1999 emerged as an attempt to increase the population's access to medicines equivalent to ones with brand, with more affordable prices. As a result of this law there was a strengthening of the national capital and a major attraction for foreign companies to brazilian market. This study aims to assess the development trajectory of the country, showing how path-dependence has culminated in greater empowerment of national pharmaceutical industries after the Generics Law in 1999

Instrumentación para el registro del color en odontología

Color is an important variable in cosmetic dentistry, and it has traditionally been measured by a visual method, comparing teeth with standard color guides. In recent decades, electronic instruments have been developed to eliminate the subjective factor of visual measurement. This objective method has mainly been performed with colorimeters, spectrophotometers and the analysis of images obtained with digital cameras. These instruments have proven to be reliable with a high degree of precision and accuracy. Its use is recommended as an adjunctive tool to assess color in direct and indirect restorations, in aesthetic treatments like bleaching, and to facilitate communication with the dental laboratory. The spectrophotometer is the device that has reported better “in- vitro “ and “in -vivo” performance, being the “Vita Easyshade “ the one with more reliable results.

A biografia como registro da memória na obra do Visconde de Taunay

Le but de cet article est de démontrer que la production de textes biographiques a été une activité constante pendant toute la carrière intellectuelle et politique du vicomte de Taunay, de façon à contribuer pour rendre célèbres des personnalités brésiliennes et étrangères qui, selon lui-même, ont joué un rôle important dans le projet de constitution de la nationalité brésilienne. Em outre, ce texte vise signaler un aspect caractéristique de la méthode biographique adoptée par l’écrivain, puisqu’il va au-délà de la chronologie tradionnelle qui considère la naissance et la mort comme points de répère identifiant le début et la fin du récit: d’autres textes (écrits ou non par lui) s’y ajoutent toujours, de manière à le rendre fragmentaire et, par conséquent, plus proche de la discontinuité et du caractère aléatoire de l’existence humaine.

Compartilhamento de informações entre os Sistemas de Cadastro e de Registro de Imóveis utilizando um SIG cadastral

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Causes for the underreporting of adverse drug events by health professionals: a systematic review

Objective: Identifying the main causes for underreporting of Adverse Drug Reaction (ADR) by health professionals. Method: A systematic review carried out in the following databases: LILACS, PAHO, SciELO, EMBASE and PubMed in the period between 1992 and 2012. Descriptors were used in the search for articles, and the identified causes of underreporting were analyzed according to the classification of Inman. Results: In total, were identified 149 articles, among which 29 were selected. Most studies were carried out in hospitals (24/29) for physicians (22/29), and pharmacists (10/29). The main causes related to underreporting were ignorance (24/29), insecurity (24/29) and indifference (23/29). Conclusion: The data show the eighth sin in underreporting, which is the lack of training in pharmacovigilance. Therefore, continuing education can increase adherence of professionals to the service and improve knowledge and communication of risks due to drug use.

Formação do técnico de enfermagem para administração segura de medicamentos: proposição de tecnologia educacional virtual

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Noção de feminilidade em Melanie Klein: subjetivações para além de um registro fálico

Pós-graduação em Psicologia - FCLAS

Diagnóstico de situação das práticas de manejo sanitário em sistemas de produção de bovinos de corte

We interviewed 21 farmers in order to access which sanitary practices adopted in the production systems of beef cattle on farms located in São Paulo, Mato Grosso, Mato Grosso do Sul and Rondonia. The survey was conducted through a qualitative approach to the collection of data obtained through questionnaire and personal interview with the landowners. We questioned the attitudes and sanitation procedures in these current production systems such as veterinary assistance, preventive health practices and disease surveillance, knowledge of health hazards for the safe production of food, animal feed, vaccine and immunizations, registration system, measures with newborns, products used in the environment and animals, grace period, employee training, destination of the dead animals, among others. Along with the data found that only 30% of properties had veterinary care, 67% said they meet the expiration dates of the products, although it was not mentioned on the products if there were any. In only 48% of properties were veterinarians who prescribed drugs to animals. Only two of the owners confirmed buying and using expired products in animals and only 48% have received some training on the property. In this setting, it is evident that farmers should be better prepared for insertion of its products in a highly demanding and competitive market. In this context, add value to the product depends mainly on the condition of sanitation of the herds.

Registro do perfil de emergência para mimetização dos dentes naturais na região estética

Introdução: o tratamento com implantes dentários para a reposição de dentes na região estética exige a utilização de materiais e técnicas que permitam o máximo de naturalidade entre a restauração, os dentes vizinhos e o tecido gengival. Dessa forma, torna-se necessário criar o correto perfil de emergência para o dente, assim como a utilização de materiais com alto potencial estético. Objetivo: o objetivo do presente trabalho foi ilustrar, através de um caso clínico, a utilização de uma técnica de moldagem para a correta cópia do perfil de emergência do dente e sua transferência para o modelo de trabalho, tornando possível a confecção de uma restauração totalmente cerâmica, perfeitamente integrada ao tecido gengival. Caso clínico: paciente de 30 anos, procurou o clínica de prótese dentária com desejo de melhorar a estética dos dentes. Após diagnóstico e planejamento, foram confeccionadas 2 coroas totalmente cerâmicas sobre os dentes 12 e 21, e confecção de 1 coroa cerâmica sobre um pilar de zircônia após o estabelecimento e registro do perfil de emergência do dente 11. Conclusão: após a conclusão do tratamento, observou-se naturalidade, estética e perfeita integração entre as restaurações, os dentes remanescentes e o tecido gengival.

Controle da placa bacteriana dentária e suas formas de registro

Dental plaque is the principal etiological agent of periodontal disease, one of oral diseases more prevalent in the world. Due existence of relation between periodontal disease and oral hygiene, on the point of periodontal view, it was developed a growing interesting by experimental research and by clinical investigations. The knowledge of problem, its extension, severity, hypothetic cause is so valuable to establish prevention, control and treatment acts. In this form, the use of plaque index becomes more and more often, being valuable the determination of discriminatory power of them. The aim of this work was to describe and analyze principal forms to register of dental plaque aiming to subsidize the researcher and dental surgeon on adoption of most adequate method for their case. Data bases: Medline, Lilacs and BBO were consulted without limit to identify the format of register of each index described on literature. It was observed the use of Oral Hygiene Index on diverse ways like: clinical evaluation of dental plaque, in products evaluation works and dental Office; patients monitoring; instruction about hygiene and oral hygiene technique. It was noted that dental plaque indexes are useful and allows the register of different forms point out the importance of its use on clinical and researches practice.

Medicamentos inadequados para idosos na estratégia da saúde da família

The ageing process can change the pharmacodynamics and pharmacokinetics parameters. Therefore, some medications are considered potentially inappropriate (PIM) for the elderly people, since they can increase the likelihood of occurrence of adverse drug events. The objectives are to estimate the frequency of use of PIM in the elderly people, with potentially hazardous drug interactions (PHDI) and to evaluate the impact of pharmaceutical intervention (PI) for the prescription of safer therapeutic alternatives. A cross-sectional study was performed in a Health Family Strategy (region of Araraquara, SP), between January and February/2012. The medical records of patients aged ≥60 years, that use at least one drug, were consulted for identification of PIM, according to the Beers criteria. The MPI identified were classified considering the Anatomical Therapeutic Chemical Classification System (ATC) and the essentiality of the drug (safety, effectiveness, quality and cost parameters) The inclusion criteria were met by 358 elderly, being that 93 of them (26%) had taken at least one PIM. Of the 114 different drugs prescribed for elderly, ten were classified as PIM, of which four of them act on the central nervous system, four on cardiovascular system and two on the digestive tract. Seven MPI are essential medicines, belonging to national list of essential drugs (RENAME-2010). Fourteen drug interactions were identified, of which two are PHDI (fluoxetine/amitriptyline and digoxin/hydrochlorothiazide).After the PI, there was no change in medical prescriptions of patients with PIM use or with DI. Medical prescriptions of elderly attended in the Health Family Strategy show pharmacotherapeutic safety problems, of which may be responsible for health hazardous for this age group. Although the intervention carried out by letter had been ineffective for the adherence of doctors in prescribing safe alternatives, wide dissemination of the lists that contain PIM and PHDI is need, as well as the inclusion of safer equivalents in RENAME, in order to contribute for rational use of drugs.