Vitrocerâmicas porosas via conformação e consolidação com amidos

The search for new methods of manufacture of glass-ceramics with controlled porosity and permeability is interesting of the industrial and commercial point of view, and a challenge of great complexity. Porous glass-ceramics produced by sintering and crystallization of glasses can find applications, for example, as filters, materials with bactericidal properties, bio-implants, as catalytic and enzymes supports, among others. An alternative and low cost method of ceramic manufacture reaching different levels of porosity, for diverse purposes, is the conformation assisted by addition of starch, known as consolidation with starch. The objective of this project is to study the process of conformation with starch for making porous glass-ceramics from a commercial glass in the system Na2O-CaO-SiO2, whose kinetics of sintering by viscous flow and surface crystallization are known. The method of conformation with starches is innovative for glass-ceramics and its development opens the way for obtaining a new class of materials. We found a possible route for the production of porous compacts of glass particles, from the powder preparation to the removal of starch. It was observed that a glass powder obtained by dry milling in a ball mill with alumina balls for 24 h, afterwards mixed with water in an eccentric ball mill for 2 h, without the addition of a deflocculant, and subsequently mixed with starch also in an eccentric ball mill for 5 min resulted in slurries stable against sedimentation

Litofácies e relações estratigráficas da formação Aquidauana no nordeste da Bacia do Paraná - São Sebastião do Paraíso (MG)

The Aquidauana Formation is characterized by sandstones of variable granulation, mudstones and diamectites abundant in clay, typical colors like brick red (vermelho tijolo) of glacial, fluvial and lacustrine origin. It’s chronostratigraphic equivalent to the Itarará group from the Neo Carboniferous age, that under the exploratory view, such units represent important intervals in the basin, occurring together with them minerals as well as energy resources as petroleum, underground water and coal – what requires a great paleogeography and stratigraphy knowledge for its exploration. By gathering information from the columnar sections of the area, it was possible to characterize the sedimentary facies, the stacking pattern as well as the association. It was also made an attempt of stratigraphic correlation, which showed great difficulties since glacial environments present a great lateral discontinuity of the facies besides the complex relationship process of formation. As a result, it was obtained 8 sedimentary facies, the lateral and vertical relations and genesis process. It is proposed that the sedimentary environment in the study area is the fluvio glacial, characterized by alluvial systems formed by defrosted water which transport the sediments that are deposited in plains in front of the glacier (distal outwash). Petrographic thin section analysis showed that the transportation process was ineffective. The grains present punctual to lobular contacts, characterizing good porosity and permeability to the rock, varying these qualities according to more or less existence of matrix. The presence of Iron Oxide deposited between the recrystallization border and feldspathic mineral indicates that this rock has possibly presented a primary rubefaction, intensified by alkaline fluid percolation

Avaliação e comparação do perfil de dissolução do Fluconazol 150mg cápsulas produto referência, genérico e similar

Fármacos com alta permeabilidade intestinal, ampla faixa terapêutica e ausência de evidências documentadas de bioinequivalência ou problemas de biodisponibilidade devido à formulação, foram considerados bioisentos pela ANVISA (RDC 37/2011), ou seja, os fármacos que se encaixam nesta categoria não necessitam de estudos de biodisponibilidade relativa/bioequivalência para serem comercializados. Dentre os catorze produtos que receberam a bioisenção da ANVISA, encontra-se o fluconazol, antifúngico aprovado atualmente para ser comercializado em vários países, inclusive no Brasil, onde inúmeras opções comerciais do produto fluconazol cápsulas, genérico ou similar, podem ser adquiridas. Tendo em vista a bioisenção do produto fluconazol cápsulas e sua larga utilização no mercado brasileiro, o estudo do perfil de dissolução deste produto torna-se relevante. Sendo assim, este trabalho avaliou 2 produtos genéricos e 2 produtos similares frente ao medicamento referência em relação aos seus perfis de dissolução e a similaridade entre eles. Os resultados foram avaliados seguindo a RDC 31/2011 da ANVISA que prevê o cálculo do fator de similaridade entre os perfis de dissolução. E, pôde-se observar que apenas 1 medicamento genérico apresentou o fator de similaridade adequado (entre 50 e 100), sendo 51,60, os demais medicamentos testes apresentaram valores fora do intervalo adotado pela ANVISA. Através desses resultados, conclui-se que intercambialidade do medicamento referência pelo medicamento genérico ou similar não é adequada, uma vez que eles não são considerados iguais, salvo um dos medicamentos genéricos.

Síntese e aplicações de inibidores peptídicos de topoisomerases associados a sistemas de liberação controlada de fármacos

O uso de novas tecnologias para o desenvolvimento de medicamentos constitui uma estratégia promissora no campo da biotecnologia. Nesse sentido, peptídeos com efeito antimicrobiano, produzidos por plantas, animais e microrganismos estão sendo utilizados como modelos para o desenvolvimento de novos medicamentos com aplicações em saúde. Resultados promissores têm sido obtidos em relação à inibição da atividade das enzimas bacterianas DNA girase e topoisomerase IV por derivados peptídicos de toxinas bacterianas, comprovados em ensaios in vitro. Porém, ensaios in vivo não demonstraram reprodutibilidade, basicamente devido à baixa permeabilidade da célula bacteriana a estes compostos. Desta forma, o objetivo deste projeto consiste em aplicar sistemas eficientes para promover o acesso de moléculas peptídicas sintéticas derivadas de toxinas bacterianas, ao meio intracelular e, consequentemente, aos seus alvos intracelulares: as enzimas DNA girase e/ou topoisomerase IV. Com isso, pretendemos solucionar a barreira técnica em que se encontram as aplicações dessa classe de biomoléculas como precursores de novos agentes antibacterianos, o que certamente causaria um importante avanço nas pesquisas desenvolvidas pelo grupo

Mapeamento geoestatístico da vulnerabilidade do Aquífero Guarani no município de Ribeirão Bonito - SP

The Guaraní aquifer has relevant importance both as a source of water for several urban centres and the development of agriculture and livestock. In recharge areas the aquifer is free and, therefore, subject to contamination of effluents and tailings deposited on soils that cover it. Thus, it becomes crucial not only its protection at all levels, as the knowledge of its degree of natural vulnerability. The present work used geostatistics modeling techniques to study the natural vulnerability of the Guaraní aquifer in the city of Rio Bonito, State of São Paulo, southeastern Brazil, where the Guarani aquifer is exposed. These techniques, extensively used in evaluation studies of mineral deposits and oil tanks, can be adapted to produce a spatial classification or a regionalisation of probabilistic indices of vulnerability. By ordinary kriging method maps of vulnerability classification were obtained. To determine the vulnerability of the aquifer was employed the Aquifer Vulnerability Index (AVI), which requires knowledge of unsaturated zone thickness and permeability. The final product was a map with probabilistic index of vulnerability of the Guaraní aquifer, which presented values between 0 to 0.33 years, framing the area studied in AVI class extremely high vulnerability

Ação dos inotrópicos e vasopressores na estabilização hemodinâmica em cães com choque séptico

Septic shock remains one of the most common challenges for the small animal practicing, presenting high mortality rates frequently associated with late identification of this syndrome, as well as an inappropriate treatment. In general, disruption of homeostasis occurs with an intense activation of inflammatory cascade, which leads to a damage to endothelial cells and an exposure to these cytokines, which will result in vasodilation and increased capillary permeability. Thus, there is a drop in blood pressure, even after aggressive fluid resuscitation. Therefore, drugs such as vasopressors, which act by increasing systemic vascular resistance, and inotropes, which have an effect on heart pump, should be administered in order to raise blood pressure, ensuring adequate tissue perfusion. The objective of this review was to gather information about the various drugs used in vasopressors/inotropes therapy, trying to explain the role of each one in different situations, in order to increase the survival rate in dogs affected with septic shock

Contribuição das águas subterrâneas para a vazão do Ribeirão Boa Vista ou Córrego do Lajeado

This paper aimed to give a contribution to improve water resources management, consists of the analysis of interaction among groundwater and streamflow, by through the analysis of the relationship between basic and total streamflow, based on measured hidrological data from Ribeirão Boa Vista or Córrego Lajeado. watershed. Comparisons among groundwaterflow in this basin with another one in Rio Corumbataí basin were made based on the specific basic flow, in order to verify the possibility of the utilization of measured hydrological data in other basins with similar geological characteristics and soil use and occupation. Based upon the comparisons that were made, specific basic flow does not represent a good tool for extrapolation of measured data, indicating that this comparison shall be weighted by others characteristics as permeability and thickness of geological formations. Finally, it was possible to conclude that basic flow may be considered as an additional parameter for analysis of hydrological and hydrogeological characteristics of a basin and to provide subsidies to release legal licenses for water resources uses. related to surface water as well as for groundwater and may also be used as a tool for consolidation of integrated management of water resources, that is considered as a necessary and essential practice to avoid conflicts between users of water resources in a river basin.

Um jogo de mapas ou sobre engano geográfico de Marília Garcia

This essay aims to analyze the book Engano geográfico Marília Garcia, published in 2012. It is a long narrative poem that recounts a trip through Spanish and French landscapes, and which allows to question various shifts of the poetic voice. One of them, marked by the duplicity between geographic and poetic journey which I could characterize as a be­ 76 Revista semestral do Programa de Pós-Graduação em Letras – UFES tween-place given by the sign of waiting. A second, through a dialogical instance that allows a process of depoetization of the language with its permeability to other voices. Finally, through the presence of several pronouns “I”, “he”, “she”, “you”, without explicit textual reference, and that would indicate a kind of closeness of the loving attention.

Concreto com adição de cinza de bagaço de cana-de-açúcar

Pós-graduação em Engenharia Civil - FEIS

Desenvolvimento e caracterização de nanopartículas poliméricas com propriedades mucoadesivas para administração oral de zidovudina

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudos de permeação e liberação de peptídeos antimicrobianos estruturalmente derivados da toxina CCDB

O uso de peptídeos sintéticos para o desenvolvimento de novas drogas é uma estratégia promissora no campo da biotecnologia. Peptídeos derivados de toxinas bacterianas intracelulares, produzidas por sistemas de morte pós-segregacional (PKS) tais como CcdB e ParE são exemplos dessa estratégia. Porém, moléculas com estrutura peptídica derivadas de toxinas bacterianas apresentam sérios problemas na aplicação terapêutica por apresentarem baixa solubilidade e difícil permeabilidade em membranas bacterianas. O objetivo desse estudo consistiu no desenvolvimento e aprimoramento de sistemas nanoestruturados (lipossomas) que permita a imobilização de análogos peptídicos da toxina CcdB e sua consequente translocação no citosol bacteriano, permitindo que os mesmos atinjam seus alvos celulares, enzimas DNA girase e Topoisomerase IV. Lipossomas do tipo SUV (small unilamellar vesicles), foram preparados pela técnica de extrusão-evaporação variando-se suas formulações. Desta forma, pretendeu-se avaliar a eficiência de encapsulação dos peptídeos através de técnicas de cromatografia líquida de alta eficiência (CLAE) e espectroscopia de UV-Vis e fluorescência. Após testes de eficiência de encapsulação, os lipossomas contendo os análogos peptídicos encapsulados, foram submetidos a ensaio de inibição de crescimento em meio líquido para duas espécies bacterianas: Staphylococcus aureus e Escherichia coli. Resultados demonstraram que a utilização de sistemas nanoestruturados é de grande importância para viabilizar a aplicação desta classe de biomoléculas em estudos terapêuticos, permitindo assim, que tais peptídeos possam ser utilizados como antibióticos promissores, se associados a sistemas de transporte e liberação controlada de moléculas peptídicas.

Síntese e estudos de sistemas de bioencapsulação associados a peptídeos antimicrobianos miméticos da toxina natural CcdB

Pós-graduação em Biotecnologia - IQ

Análise estrutural de tubos de concreto armado com resíduo de borracha de pneu

Pós-graduação em Engenharia Civil - FEIS

Criopreservação de oócitos de Prochilodus lineatus (Valenciennes, 1836) (Teleostei, Prochilodontidae)

Pós-graduação em Ciência e Tecnologia Animal - FEIS

A noção de esquema corporal na filosofia de Merleau-Ponty: análises em torno da 'Fenomenologia da Percepção'

The Throughout the work of Merleau-Ponty, besides philosophical concepts and images of his thinking, some theoretical-anthropological devices exist that reveal his approximation of human sciences. That is the case of the notion of body schema. Interested in discussing the role the critical development of this concept may have played in the passage from the first phase of his work to the period when the philosopher finds himself able to outline a new ontology, in this paper, we study the presence of the body schema notion in the Phenomenology of perception. We show that, in this book, Merleau-Ponty unsubstantiates the notion under analysis which, from a cognitive core that organizes our bodily experience, turns into the expression of our body parts’ mutual permeability, but also of the body’s permeability towards the world and other people.