Maternal Western Style Diet Increases Susceptibility to Chemically-Induced Mammary Carcinogenesis in Female Rats Offspring

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo teórico da contribuição à dose de partículas secundárias geradas por prótons de energias entre 100 e 200 MeV num Phantom de substituto de tecido MS20

The goal of this project is the reproduction, through the simulation code based on the MCNPX (Monte Carlo N-Particle eXtended) v2.50 method, of the proton beam interaction with the material, since, in proton therapy, only the particle ionization and excitation are analyzed and the occurence of nuclear interactive inelastic process are not considered. This work will help the development of studies concerning the contribution to the total dosis of secondary particles generated by nuclear interaction in proton therapy. They are: alpha particles ( ), deuterium(2H), tritium (3H), neutron (n) and helium (3He). A MS20 tissue substitute phantom was used as the target and the energy of the proton beams was within an interest range of 100 to 200MeV. With the results obtained, it was possible to generate graphics which allows the analysis of the dosis deposition relation with and without nuclear interaction, the percentage of secondary particles deposited dosis, the radial dispersion of neutrons in the material, the secondary particles multiplicity, as well as the relation between the secondary particles spectrum with the próton generated spectrum

Preposições em textos do gênero notícia na imprensa paulista: norma e uso no ínicio do século XX

This paper proposes a reflection on processes of variation and change that occurred with the portuguese prepositions a, ate, em and para, taken as a parameter for answers in a broader context, the confrontation between the norm and use and between standard and linguistic variation. We conducted the study based on a corpus composed of all occurrences of the prepositions in question removed news of the newspaper O Combate and O Estado de Sao Paulo. Whereas the main objective of the study is to present and describe the use of these particles in newspaper articles of the Imprensa Paulista, data were collected and quantified by using the statistical package GOLDVARB, and interpretation of results relied (i) assumptions regarding the process variation in the use of prepositions and prepositions replace weak, as the preposition to, for strong prepositions (para, em, até), (ii) in comparison with the grammatical rule in effect at the time, (iii) and in the search for the existence of some historical factor that justifies the selection of a preposition rather than another. Among the hypotheses, we investigate the relationship between these prepositions and whose kind of preachers they introduce supplements: the direction of motion (abstract or concrete) or transfer (material and verbal / perceptual). This theoretical perspective was the Labovian sociolinguistics (Labov, 1972, 1994), which defines the linguistic variable as a representation of two or more different ways to convey a certain information content, being necessary to define it the following criteria set exact number of variants to establish all the multiplicity of contexts in which it appears; develop a quantitative index for measuring the values of variables

Estudo teórico da contribuição a dose de partículas secundárias geradas por prótons de energias entre 100-200 MeV num phantom de músculo estriado

In the treatment plans in conventional Proton therapy are considered only the elastic interactions of protons with electrons and/or nuclei, it means, mainly ionization and coulomb excitation processes. As the energy needed to reach the deep tumors should be of several hundred of MeVs, certainly the nuclear inelastic channels are open. Only some previous studies of the contribution of these processes in the full dose have been made towards targets composed of water. In this study will be presented the results of the simulation of the processes of interaction of beams of protons in the range of 100-200 MeV of energy with a cylindrical phantom composed by striated muscle (ICRU), emphasizing in the contribution to total dose due to the deposition of energy by secondary particles alpha (α), deuterium (2H), tritium (3H), neutron (n) and hélio3 (3He), originated by nuclear inelastic processes. The simulations were performed by using the method of Monte Carlo, via the computer code MCNPX v2.50 (Monte Carlo N-Particle eXtended). The results will be shown demonstrated through the graphics of the deposited dose with or without nuclear interaction, the percentual of dose deposited by secondary particles, the radial dispersion of neutrons, as well as the multiplicity of secondary particles

Estudo teórico da contribuição à dose de partículas secundárias geradas por Prótons de energias entre 100 e 200 MeV num Phantom de osso cortical

In proton therapy, the deposition of secondary particles energy originated by nuclear inelastic process (n, 2H, 3H, 3He and α) has a contribution in the total dose that deserves to be discussed. In calculations of plans implemented for routine treatment, the paid dose is calculated whereas the proton loses energy by ionization and or coulomb excitement. The contribution of inelastic processes associated with nuclear reactions is not considered. There are only estimates for pure materials or simple composition (water, for example), because of the difficulty of processing targets consisting of different materials. For this project, we use the Monte Carlo method employing the code MCNPX v2.50 (Monte Carlo N-Particle eXtended) to present results of the contribution to the total dose of secondary particles. In this work, it was implemented a cylindrical phantom composed by cortical bone, for proton beams between 100 and 200 MeV. With the results obtained, it was possible to generate graphics to analyze: the dose deposition relation with and without nuclear interaction, the multiplicity and percentage of deposited dose for each secondary particle and a radial dispersion of neutrons in the material

Agricultura familiar em Rio Claro - SP: em busca de alternativas para permanência no campo

As we focusing in the Brazilian rural area we see that it presents the spatial diversity and the different organization forms of the space arising from its diversity, tied to the different economic, social, politic and cultural contexts .These contextual diversities bring results that is not limited to the agrarian sector, but get beyond the border of the rural world, taking different ways of organization and structuring in the urban areas. The building and management of the rural spaces are constituted as an attribute of the agricultural production that in the course of the centuries made disappear and reduce significant proportions from the natural areas. In many places, the intensification of the production process gives satisfaction to the globalized markets and that return allows the reproduction of the productive conditions. In other areas the access difficulties to the market and the proximity to the developed urban centers cause the abandonment of the agricultural activity and the maintenance of property without production or with specific services (tourism, for example). That process triggers a multiplicity of factors that are defining the pace of the rural areas in Brazil. This work sought to understand all the deals of the ‘’rural’’ county of Rio Claro-SP and what’s the role and the situation that we find the familiar agriculture in the advanced urban areas, which is the case of this study. Where the agriculture doesn’t represent the flagship of the economy. It was the intention, identify what activities and practices socio-spatial are developed in the county rural area. Trying to understand the public politics acts in the promotion and encouragement to the already developed activities or even other activities that can represent the possibility of a social and territorial reproduction of the families on the country

Estudo das políticas de obtenção dos assentamentos de reforma agrária no Brasil entre 1985 e 2009

Understanding the territorial transformations is important to the geographic knowledge, especially when it is related to structural questions as agrarian one. In this way, the land acquisition to agrarian reform enables us to understand some of these transformations, represented by territorialization of landless workers in rural settlements, that are concrete results of the struggle for land that boost the policies of agrarian reform in our country. The renewal of the agrarian structure is fundamental to the concept of land reform and also provides that advances social, political, cultural, economic, etc. Classified as a country with rates of the highest land concentration in the world, Brazilian government attempts to base his actions to take in the expropriation of land the main character of the land reform. However, new policies have been gradually used to obtaining the rural settlements, in a process that Fernandes (2010) called the reconceptualization of land reform. Starting in 1985, Brazil has 63% of the beneficiaries of land reform policies settled on expropriated land, the rest is a result of incorporation policies such as land regularization, of land reform and land purchase. Such policies generate changes in agrarian structure, that is the goal of land reform, but don´t concentrate to the land ownership. This attitude of the state in coping with the agrarian question is his response to the pressures of capitalist agriculture represented by landowners and agribusiness, coping catching an intense and uneven territorial dispute with peasant agriculture, in an attempt to impose its model of development for the field. The aimed of this present study is to understand better the land reform acquisition and its implications in the Brazilian territory, in order to understand it in their multiplicity.

O Grande Mentecapto: romance carnavalizado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Oficinas de leitura, interpretação e produção textual no ensino fundamental

This paper describes a project called “Development of educational workshops on text reading, interpretation and writing in elementary school”, which took place at the São Paulo State University (UNESP) with financial support given by the PROEX-UNESP (Pro-Rectorate of Extension). This project aimed to organize and run educational workshops on reading, interpreting and writing different genres for students enrolled at a public elementary school in São José do Rio Preto, São Paulo state. The analysis of the texts produced by the students unfolded the project into two essential approaches. In the first one, it was possible to identify problems and inaccuracies in language usage, which was the starting point to prepare the minicourses that would be offered. These mini-courses promoted a deep involvement of undergraduate students (in Portuguese Language and Literature) with the practice of Portuguese teaching at the school. In the second one, 5.468 texts, which were produced during the four-year project, founded researches whose goal is to describe processes in which there is a relation between speech and writing, and are based on a theoretical framework that values the multiplicity of literacies associated with social practices experienced by the students. Thus, this extension project aimed to articulate the service to the external community – in this case, public school students - to the internal community – undergraduate students in Portuguese Language and Literature.

A multiplicidade poética de Emílio Moura: o encanto da hora amarga

The modernist poet Emílio Moura (1902-1971) incorporates a strictly modern language regarding the imagistic suggesting a mainly poetry metalinguistic. That way, from the works Canto da hora amarga (1932) and Cancioneiro (1944) we attest, through the poetic analysis, that modernity Moura’s poetry takes place in confluences with ideas ranging from biblical tradition and come to the depersonalization of the modern I and questing. We objectify, therefore, demonstrate and explore the metalinguistic and intertextual character that results in the personification of poetry, as clarified muse. To achieve this, this same poetry undergoes a dualistic and pessimistic sentiment, baroque, the I that is divided into life and death, light and shadow; goes through a romantic feeling of anguish and desolation and reaches the multiplicity of the poetic speaker, which promotes a constant struggle with the language. More than draw a correlation between classical and modern ideas (in the sense that the poet creates depersonalization and appropriates of free, short prose or verse, typical of modernism), intend to supply, at least in part, the dearth of studies on the miner poet who has found fertile ground to question and analyze internally the role of poetry in the multiplicity of man and modern society to therefore conclude that universalism the Emílio Moura becomes distinctive and mature. Thus, we will check how poetic inflows corroborate both works for reevaluation and critical insertion of poetic the Emílio Moura in the context of modern/Modernist Brazilian literature

Perfil da farmacoterapia utilizada por idosos institucionalizados: uma análise dos problemas relacionados ao uso de medicamentos em instituições de longa permanência para idosos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Discurso e identidade feminina na mídia impressa: a evolução da mulher no mercado de trabalho

The female identity in relation to the multiplicity of roles of contemporary women and their evolution in the labor market is the focus of the work that is developed from studies of French line Discourse Analysis refered to Michel Pêcheux and Michel Foucault. The objective is to reflect on the discursive mechanisms of print media, focusing on Veja magazines covers, which, by its verbal and visual language, constructs meaning effects and disseminates certain social thruths about the female changes. Considering that this media aspect plays an important role on society's opinion formation, it is worth to investigate, analyse and describe the elements present on the covers, as seduction and persuasion objects. The work analysis material is formed by six covers published by Veja magazine in the period of 1968-2012, which raise the theme of women in the labor market and show us their evolution and the changes in the representations about the female universe and the work in society

O ensino de Português Língua Estrangeira no contexto virtual do Teletandem: aspectos linguístico-discursivos

The project Teletandem, linked to the Centro de Línguas e Desenvolvimento de Professores UNESP/Assis, promotes the interaction between undergraduates students in Languages and undergraduates students from foreign universities in order to promote the teaching of Portuguese for those who do not speak Portuguese and give an opportunity to Brazilian students to learn a foreign language. Therefore there is a different context that can result in new forms of statements produced in this specific area of human activity. The present paper aims to present a description of Teletandem sessions as a discursive gender according to the gender theory, showing the multiplicity of discursive genders that emerge during an interaction. We also intend to verify the levels of Critical Language Awareness among Brazilian participants according to the Critical Discourse Analysis.

Transient expression of rabies virus G-glycoprotein using BHK-21 cells cultured in suspension

Objective To assess the expression of rabies virus G-glycoprotein (RVGP) expression using Semliki Forest virus as a vector in combination with BHK-21 cells cultured in suspension. Results A multilevel factorial design was used to quantify effects of temperature (33–37 C), fresh medium addition after the viral adsorption step (100–200 % with respect to the initial cell suspension volume before infection) and harvest time (8–40 h) on RVGP production. Experimental runs were performed in 24-well cell culture plates at a multiplicity of infection (MOI) of 16. An additional experiment in spinner-flask was performed at MOI of 9, using the optimal conditions determined in cell culture plates. Values for temperature, fresh medium addition and harvest time of 33 C, 100 % and 16 h, respectively, ensured the optimal RVGP production in culture plates. The volumetric yield (239 ng ml-1 ) in these conditions was higher than that reported previously for adherent cell culture. In spinner-flasks, the volumetric yield was improved (559 ng ml-1 ). Conclusion These results establish the basis for designing bioprocess to produce RVGP.

Arte e filosofia como disciplinas das multiplicidades: problema filosóficos e problemas estéticos em interferência intrínseca, segundo Deleuze

The most challenging Deleuze/Guattari’s lesson regar- ding art is that it is an autonomous way of thinking and bears of no lack relatively to philosophy and science. In fact, creating artistically is thinking. Throughout this article, I will try to show that art and philosophy are autonomous modes of thinking, as far as the statute of their creations is multiplicity. The multiplicity that characterizes philosophy is concept; the multiplicity that characterizes art is sen- sation. Both of them have their multiplicity character guaranteed by the instance of the problems, to which they are solutions. The most important is that the problems although independent constitute in- terference channels through which two modalities of meeting could happen. First, sensations point out how could a thinker endures in the instance of problems, avoiding both to deprive the concept and to fall in philosophical illusions. In second place in the instance of the problem philosophy and art exchange, so that either a thinker takes an art sensation and extracts from it its generating problem to be philosophically solved or, vice-versa, an artist takes a concept and solves its problem creating new art sensations.