Efeitos anti-inflamatório e antitumoral dos constituintes de Qualea grandiflora no tumor de Ehrlich

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Low serum potassium levels increase the infectious-caused mortality in peritoneal dialysis patients: a propensity-matched score study

Background and ObjectivesHypokalemia has been consistently associated with high mortality rate in peritoneal dialysis. However, studies investigating if hypokalemia is acting as a surrogate marker of comorbidities or has a direct effect in the risk for mortality have not been studied. Thus, the aim of this study was to analyze the effect of hypokalemia on overall and cause-specific mortality.Design, Setting, Participants and MeasurementsThis is an analysis of BRAZPD II, a nationwide prospective cohort study. All patients on PD for longer than 90 days with measured serum potassium levels were used to verify the association of hypokalemia with overall and cause-specific mortality using a propensity match score to reduce selection bias. In addition, competing risks were also taken into account for the analysis of cause-specific mortality.ResultsThere was a U-shaped relationship between time-averaged serum potassium and all-cause mortality of PD patients. Cardiovascular disease was the main cause of death in the normokalemic group with 133 events (41.8%) followed by PD-non related infections, n=105 (33.0%). Hypokalemia was associated with a 49% increased risk for CV mortality after adjustments for covariates and the presence of competing risks (SHR 1.49; CI95% 1.01-2.21). In contrast, in the group of patients with K < 3.5mEq/L, PD-non related infections were the main cause of death with 43 events (44.3%) followed by cardiovascular disease (n=36; 37.1%). For PD-non related infections the SHR was 2.19 (CI95% 1.52-3.14) while for peritonitis was SHR 1.09 (CI95% 0.47-2.49).ConclusionsHypokalemia had a significant impact on overall, cardiovascular and infectious mortality even after adjustments for competing risks. The causative nature of this association suggested by our study raises the need for intervention studies looking at the effect of potassium supplementation on clinical outcomes of PD patients.

Apoptose no carcinoma de próstata

Pós-graduação em Patologia - FMB

Hipertensão e diabetes mellitus: perfil assistencial e de usuários em uma unidade de saúde do interior paulista

Pós-graduação em Saúde Coletiva - FMB

Screening da atividade antiproliferativa e investigação toxicológica in vitro e in vivo de compostos de coordenação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O tabaco é um dos principais fatores etiológicos do câncer bucal: conceitos atuais

Neoplasm, tumor or cancer generic synonymies are used to designate a group of diseases that affect any part of the body.Their main common feature is the abnormal cell proliferation, usually rapid, uncontrolled and unrestrained. According to World HealthOrganization (WHO) cancer is the leading cause of death worldwide. In 2005, a total of 58 million deaths, 7.6 million (or 13%) of all of them were cancer. Among the factors that favor its development, the tobacco is considered one of the main villains. Therefore, this article, we will discuss the basics and updates about oral cancer and tobacco consumption.

Efeitos do treinamento misto na promoção da saúde e sua interferência no perfil lipidêmico em indivíduos diabéticos tipo 2

Diabetes is a chronic disease that currently affects 171 million individuals approximately worldwide, with projection to reach 366 million people in 2030, increasing the prevalence of 2.8% in 2000 to 4.4%. The dyslipidemia is certainly one of the associated metabolic alterations most important, if we consider the main cause of death in Diabetes - the cardiovascular disease (CVD). One of the prevention and help factors in the Diabetes treatment and in the fall of associated complications is the physical exercise, which contributes to a better life quality to the diabetic. The main objective of the work was to evaluate the effect of a mixed physical exercises training program (aerobic/anaerobic with pause-active), including walking exercises, weightlifting and swiss ball, about possible changes in the blood lipid profile of adult individuals type 2 diabetics. The methodology used an experimental model of pre-test and post-test applied to the group. The data were first analyzed in a descriptive way for the normalization and the elaboration of averages and sample diversions. The sample was subdivided in two moments, being one pre and other post then weeks of training. After these procedures, the results of the values of the lipidic profile and glycemia were compared between the pairs pre and post training (test T Student, pair data), non-parametric. With the study, we can conclude that in despite of the low uptake of participants in the search, for reasons already cited, and the great age difference between them, the found results were partially satisfactory, because we achieved significant changes only in the glycemic variables, but we suggest future studies in the molds here proposed.

Avaliação dos marcadores prognósticos de pacientes com DPOC no período de nove anos

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Cateterismo cardíaco: da compreensão do usuário ao planejamento das orientações de enfermagem

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Relações socioambientais: os casos de mortalidade por infarto do miocárdio na cidade de Teresina-PI

Pós-graduação em Geografia - IGCE