Parâmetros farmecocinéticos e atividade endectocida de uma nova formulação contendo avermectinas, via tópica (pour-on), em bovinos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo farmacocinético e farmacodinâmico de cloridrato metadona por via oral, intramuscular e intravenosa e carreadores lipídicos nanoparticulados de metadona via oral em equinos

Pós-graduação em Anestesiologia - FMB

Atividade endectocida, segurança clínica e farmacocinética de resíduos de uma nova alternativa terapêutica (Fluazuron + Abamectina) em bovinos

Pós-graduação em Medicina Veterinária - FCAV

A farmacocinética da metadona e seus efeitos antinociceptivos, comportamentais e sobre a concentração alveolar mínima de sevofluorano em felinos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Farmacologia clínica da metadona peridural e intravenosa em cães

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Microemulsões biocompatíveis de anfotericina B para administração oral: estudo estrutural, liberação in vitro e farmacocinética pré-clínica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise químico-farmacêutica de preparações injetáveis de Aztreonam

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Leishmanicidal Activities of Novel Synthetic Furoxan and Benzofuroxan Derivatives

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Farmacocinética da gentamicina asministrada pela via intravensa regional em equinos com a utilização de modelos de torniques

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A famacocinética e os efeitos sedativos e comportamentais dos cloridratos de xilazina e de detomidina, administrados por diferentes vias, em asininos Nordestinos (Equus sinus)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Dendrimer nanocarriers for transport modulation across models of the pulmonary epithelium

The purpose of this study was to determine the effect of PEGylation on the interaction of poly(amidoamine) (PAMAM) dendrimer nanocarriers (DNCs) with in vitro and in vivo models of the pulmonary epithelium. Generation-3 PAMAM dendrimers with varying surface densities of PEG 1000 Da were synthesized and characterized. The results revealed that the apical to basolateral transport of DNCs across polarized Calu-3 monolayers increases with an increase in PEG surface density. DNC having the greatest number of PEG groups (n = 25) on their surface traversed at a rate 10-fold greater than its non-PEGylated counterpart, in spite of their larger size. This behavior was attributed to a significant reduction in charge density upon PEGylation. We also observed that PEGylation can be used to modulate cellular internalization. The total uptake of PEG-free DNC into polarized Calu-3 monolayers was 12% (w/w) vs 2% (w/w) for that with 25 PEGs. Polarization is also shown to be of great relevance in studying this in vitro model of the lung epithelium. The rate of absorption of DNCs administered to mice lungs increased dramatically when conjugated with 25 PEG groups, thus supporting the in vitro results. The exposure obtained for the DNC with 25PEG was determined to be very high, with peak plasma concentrations reaching 5 mu gmL(-1) within 3 h. The combined in vitro and in vivo results shown here demonstrate that PEGylation can be potentially used to modulate the internalization and transport of DNCs across the pulmonary epithelium. Modified dendrimers thereby may serve as a valuable platform that can be tailored to target the lung tissue for treating local diseases, or the circulation, using the lung as pathway to the bloodstream, for systemic delivery.

Lipid peroxidation: the role or Ca2+ and protection by calcinine

When calcinine (A-23187) (2 mu M), a known Ca2+ ionophore, is present, a significant protection is observed to a mitochondrial suspension undergoing lipid peroxidation by Fe2+-citrate complex. A-23187 can remove Ca2+, which seems to have an important role in the lipid peroxidation process, from its 'lesive sites' and consequently preventing the damage. This information has importance in terms of knowing the mechanisms and avoiding the damages of lipid peroxidation that occur in some pathological cases such as tumor promotion and hemochromatosis.

Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches

We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4″- nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino] -diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate product, 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino) pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (6), as well as the synthesis of the antimalarial primaquine prodrug 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl) amino]- 5-dioxide (7) are also described, together with their total 1H- and 13C-NMR assignments. © 2008 by MDPI.