Toxicidade e interação de proteínas Cry1 de Bacillus thuringiensis em Helicoverpa armigera (Hübner) (Lepidóptera: Noctuidae)

Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV

Análise histológica e histomorfométrica do processo de reparo de defeitos ósseos em ratos diabéticos preenchidos com osso autógeno e recobertos por membrana de matriz óssea homógena ou por membrana de politetrafluoretileno

Pós-graduação em Odontologia - FOA

Avaliação da liberação sustentada de fármaco e nanopartícula utilizando membranas de látex natural como carreador

Pós-graduação em Biotecnologia - IQ

Avaliação dos impactos ambientais gerados pelos automóveis na cidade de Ilha Solteira-SP

Pós-graduação em Engenharia Civil - FEIS

Programação térmica fetal e duração da fase de eclosão: efeitos sobre a qualidade na eclosão, variáveis sanguíneas, preferência térmica e resposta ao desafio térmico de pintos fêmeas

Pós-graduação em Zootecnia - FCAV

Total sugars in atmospheric aerosols: an alternative tracer for biomass burning

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Zidovudine-poly (L-lactic acid) solid dispersions with improved intestinal permeability prepared by supercritical antisolvent process

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3-adrenoceptor activation and α1-adrenoceptor blockade

Mirabegron is the first β3-adrenoceptor (AR) agonist approved for treatment of overactive bladder syndrome (OAB). This study aimed to investigate the effects of β3-adrenoceptor (AR) agonist mirabegron in mouse urethra. The possibility that mirabegron exerts α1-AR antagonism was also tested in rat smooth muscle preparations presenting α1A- (vas deferens and prostate), α1D- (aorta) and α1B-AR (spleen). Functional assays were carried out in mouse and rat isolated tissues. Competition assays for the specific binding of [(3) H]Prazosin to membrane preparations of HEK 293 cells expressing each of the human α1-ARs, as well as β-AR mRNA expression and cyclic AMP measurements in mouse urethra were performed. Mirabegron produced concentration-dependent urethral relaxations that were right shifted by the selective β3-AR antagonist L 748,337, but unaffected by β1- and β2-AR antagonists (atenolol and ICI 118,551, respectively). Mirabegron-induced relaxations were enhanced by the phosphodiesterase-4 inhibitor rolipram, and this agonist stimulated cAMP synthesis. Mirabegron also produced rightward shifts in urethral contractions induced by the α1-AR agonist phenylephrine. Schild regression analysis revealed that mirabegron behaves as a competitive antagonist of α1-AR in urethra, vas deferens and prostate (α1A-AR, pA2  ≅ 5.6) and aorta (α1D-AR, pA2  ≅ 5.4), but not in spleen (α1B-AR). The affinities estimated for mirabegron in functional assays were consistent with those estimated in radioligand binding with human recombinant α1A- and α1D-ARs (pKi ≅ 6.0). The effects of mirabegron in urethral smooth muscle are the result of β3-AR agonism together with α1A / α1D-AR antagonism.

Aspectos técnicos, econômicos e de sustentabilidade da produção de hidrogênio renovável

Pós-graduação em Engenharia Mecânica - FEG

Jogo digital e analogias: uma proposta para o ensino de Cinética Química

Pós-graduação em Educação para a Ciência - FC

Estudo comparativo do desempenho de diferentes membranas oclusivas de Látex Natural no reparo ósseo

Introduction: In dentistry, alveolar bone resorption is a limiting factor in the well being of individuals directly interfering in the stomatognathic system, causing problems in the context of overall health. Aiming to promote biological methods that can stimulate bone regeneration, several biomimetic strategies have been developed by the use of diverse materials possible to the bone matrix, culminating in the development of techniques that promote such repair. Objective: This work is a comparative study of the performance of films made with latex as occlusive membrane for Guided Bone Regeneration (GBR) procedure in three preparations: Latex preserved in ammonia, produced by Latex rubber clones IAN873 and PR255 polymerized immediately after collection and without use ammonia as a preservative. Methods: Sixty Wistar rats were randomly divided into 4 groups of 15 animals in which bone defects of critical size (8mm diameter) were made surgically in the skull. Group A was treated by GBR through the membrane latex preserved with ammonia, Group B received the membrane made of latex from IAN873, Group C, the membrane clone PR255 and group D was not treated by GBR. After a period of 7, 15 and 50 days, 5 animals from each group were euthanized, and specimens containing bone defect collected for microscopic examination (descriptive histology and histomorphometry). Results: The results showed that after 50 days there was bone formation in higher proportions in group D (p <0.05, ANOVA followed by Tukey), suggesting that further experiments should be conducted to conclude about the presence of ammonia and the influence of kind of rubber. Conclusion: GOR is a procedure proven effective in the treatment of bone defects. Therefore, further experiments should be conducted to reach a conclusion regarding the presence of ammonia in the latex composition for the manufacture of membranes, as well as the difference induced by the species of rubber.

Scaffold nanoestruturado utilizando-se celulose bacteriana/fosfatos de cálcio para regeneração óssea

Pós-graduação em Biotecnologia - IQ

Qualidade da operação na cultura da cana-de-açúcar utilizando cartas de controle

Pós-graduação em Agronomia (Ciência do Solo) - FCAV

Ritmo sinoventricular secundário a hipercalemia em gatos com obstrução uretral: breve descrição de três casos

Hyperkalemia is a common electrolyte imbalance in cats with obstructive feline lower urinary tract disease (FLUTD). The effects of serum potassium elevation in heart rhythm are serious and potentially lethal. The clinical manifestations reflect changes in the excitability of the cell membrane. Increased potassium levels lead to a reduction of the resting membrane potential of heart muscle cells, making them less excitable and resulting in cardiac arrhythmias. The sinoventricular rhythm with atrial arrest is among the types of arrhythmias caused by hyperkalemia. The purpose of this report was to highlight the importance of electrocardiographic monitoring for the early detection of potentially lethal arrhythmias in cats with obstructive FLUTD. We hereby describe the occurrence of three cases treated at the Small Animal Clinic of FMVZ/Unesp, Botucatu Campus.

Conservação refrigerada de abacate 'hass' e 'fuerte' submetidos à atmosferas modificadas ativas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)