145 resultados para Proteostasis Deficiencies
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Pós-graduação em Ciências Odontológicas - FOAR
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Medicina Veterinária - FMVZ
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Este artigo tem como motivação inicial inquietações nascidas da leitura de alguns trabalhos que se apresentam como projetos de pesquisa em Ciências Sociais. Mais especificamente, nos chama atenção a discussão freqüentemente apresentada como procedimentos metodológicos. Em nome de um enfrentamento das deficiências que ali julgamos presentes, procuramos resgatar traços de uma trajetória da discussão sobre o método. Nesse itinerário, assumimos como pressuposto subjacente que cada um dos clássicos fundadores conhecia o que há de fundamental na tradição da reflexão sobre o tema.
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A significação das manifestações contidas na Revista, órgão cultural publicado em 1833 pela Sociedade Filomática da Faculdade de Direito de São Paulo, é obtida por meio da leitura do sentimento nacional nela expresso. As colocações teórico-literárias, sociais e outras podem ser retrógradas ou progressistas, mas todas se colocam baixo o crivo de teor exclusivamente pragmático: o de denúncia e/ou correção de carências existentes no país ou ainda de exaltação de conquistas modestas, não obstante nossas. Portanto, é o agudo sentimento de nacionalismo que justifica a Revista e lhe dá razão de ser. The significance of the manifestations found in the Revista (Port. For Journal), official cultural publication issued in 1833 by the Philomatic Society of the São Paulo school of Law, is obtained through the reading of the national feeling it expresses. The theoretico-literary and social positions, and others, may be backward or progressive, but all of them are placed under exclusively pragmatic screening: that of denunciation and/or correction of deficiencies existing in the country, or yet, the exhaltation of our conquests, moderate as they might be. It is the deep national feeling, therefore, which justifies the existence of the Revista.
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Pós-graduação em Agronomia (Produção Vegetal) - FCAV
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Pós-graduação em Agronomia (Energia na Agricultura) - FCA
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An evaluation of organizational performance requires studies that encompass the specificities of the object under analysis, which is valid for health organizations. However, this type of organization has little support from Administration techniques and knowledge, thus generating deficiencies in management and control. As a result, the objective of this article is to develop a model for evaluating the specific performance of philanthropic hospitals and to compare the efficiency of those organizations. A theoretical model was createdand subsequently validated by specialists. A data envelopment analysis was conducted by means ofusing the data from 70 hospitals, collected in afield research. The conclusion is that there is no great availability of managerial information in Brazilian hospitals, and elements were pointed out for increasing sample efficiency.
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The aim of this study was to develop an objective method to determine the incidence of pleiomorphisms and its influence on the distribution of sperm morphometric subpopulations in ejaculates of howling monkeys (Alouatta caraya) by using a combination of computerized analysis system (ASMA) and principal component analysis (PCA) methods. Ejaculates were collected by electroejaculation methods on a regular basis from five individuals maintained under identical captive environmental, nutritional, and management conditions. Each sperm head was measured for dimensional parameters (Area [A, (square micrometers)], Perimeter [P, (micrometers)], Length [L, (micrometers)], and Width [W, (micrometers)]) and shape-derived parameters (Ellipticity [(L/W)], Elongation [(L - W)/(L + W)], and Rugosity [(4 pi A/P-2)]). PCA revealed two principal components explaining more than the 96 % of the variance. Clustering methods and discriminant analyzes were performed and seven separate subpopulations were identified. There were differences (P < 0.001) in the distribution of the seven subpopulations as well as in the incidence of abnormal pleiomorphisms (58.6 %, 49.8 %, 35.1 %, 66.4 %, and 55.1 %, P < 0.05) among the five donors tested. Our results indicated that differences among individuals related to the incidence of pleiomorphisms, and sperm subpopulational structure was not related to the captivity conditions or the sperm collection method, since all individuals were studied under identical conditions. In conclusion, the combination of ASMA and PCA is a useful clinical diagnostic resource for detecting deficiencies in sperm morphology and sperm subpopulations in A. caraya ejaculates that could be used in ex situ conservation programs of threatened species in Alouatta genus or even other endangered neotropical primate species.