Determination of disease biomarkers in Eucalyptus by comprehensive two-dimensional gas chromatography and multivariate data analysis

In this paper is reported the use of the chromatographic profiles of volatiles to determine disease markers in plants - in this case, leaves of Eucalyptus globulus contaminated by the necrotroph fungus Teratosphaeria nubilosa. The volatile fraction was isolated by headspace solid phase microextraction (HS-SPME) and analyzed by comprehensive two-dimensional gas chromatography-fast quadrupole mass spectrometry (GC. ×. GC-qMS). For the correlation between the metabolic profile described by the chromatograms and the presence of the infection, unfolded-partial least squares discriminant analysis (U-PLS-DA) with orthogonal signal correction (OSC) were employed. The proposed method was checked to be independent of factors such as the age of the harvested plants. The manipulation of the mathematical model obtained also resulted in graphic representations similar to real chromatograms, which allowed the tentative identification of more than 40 compounds potentially useful as disease biomarkers for this plant/pathogen pair. The proposed methodology can be considered as highly reliable, since the diagnosis is based on the whole chromatographic profile rather than in the detection of a single analyte. © 2013 Elsevier B.V..

Measurement of differential top-quark-pair production cross sections in pp collisions at √s = 7TeV

Normalised differential top-quark-pair production cross sections are measured in pp collisions at a centre-of-mass energy of 7 TeVat the LHC with the CMS detector using data recorded in 2011 corresponding to an integrated luminosity of 5. 0 fb-1. The measurements are performed in the lepton+jets decay channels (e+jets and μ+jets) and the dilepton decay channels (e+}e-, μ+μ-, and μ±e∓). The tt̄ differential cross section is measured as a function of kinematic properties of the final-state charged leptons and jets associated to b quarks, as well as those of the top quarks and the tt̄ system. The data are compared with several predictions from perturbative QCD calculations up to approximate next-to-next-to-leading-order precision. No significant deviations from the standard model are observed. © 2013 CERN for the benefit of the CMS collaboration.

Measurement of the tt̄ production cross section in the τ+jets channel in pp collisions at √s = 7 TeV

The top-quark pair production cross section in 7 TeV center-of-mass energy proton-proton collisions is measured using data collected by the CMS detector at the LHC. The measurement uses events with one jet identified as a hadronically decaying τ lepton and at least four additional energetic jets, at least one of which is identified as coming from a b quark. The analyzed data sample corresponds to an integrated luminosity of 3.9 fb-1 recorded by a dedicated multijet plus hadronically decaying τ trigger. A neural network has been developed to separate the top-quark pairs from the W+jets and multijet backgrounds. The measured value of σtt̄= 152 ± 12,(stat.) ± 32,(syst.) ±,(lum.) pb is consistent with the standard model predictions. © 2013 CERN for the benefit of the CMS collaboration.

Recovery of pulmonary structure and exercise capacity by treatment with granulocyte-colony stimulating factor (G-CSF) in a mouse model of emphysema

Emphysema is a chronic obstructive pulmonary disease characterized abnormal dilatation of alveolar spaces, which impairs alveolar gas exchange, compromising the physical capacity of a patient due to airflow limitations. Here we tested the effects of G-CSF administration in pulmonary tissue and exercise capacity in emphysematous mice. C57Bl/6 female mice were treated with elastase intratracheally to induce emphysema. Their exercise capacities were evaluated in a treadmill. Lung histological sections were prepared to evaluate mean linear intercept measurement. Emphysematous mice were treated with G-CSF (3 cycles of 200 μg/kg/day for 5 consecutive days, with 7-day intervals) or saline and submitted to a third evaluation 8 weeks after treatment. Values of run distance and linear intercept measurement were expressed as mean ± SD and compared applying a paired t-test. Effects of treatment on these parameters were analyzed applying a Repeated Measures ANOVA, followed by Tukey's post hoc analysis. p < 0.05 was considered statistically significant. Twenty eight days later, animals ran significantly less in a treadmill compared to normal mice (549.7 ± 181.2 m and 821.7 ± 131.3 m, respectively; p < 0.01). Treatment with G-CSF significantly increased the exercise capacity of emphysematous mice (719.6 ± 200.5 m), whereas saline treatment had no effect on distance run (595.8 ± 178.5 m). The PCR cytokines genes analysis did not detect difference between experimental groups. Morphometric analyses in the lung showed that saline-treated mice had a mean linear intercept significantly higher (p < 0.01) when compared to mice treated with G-CSF, which did not significantly differ from that of normal mice. Treatment with G-CSF promoted the recovery of exercise capacity and regeneration of alveolar structural alterations in emphysematous mice. © 2013.

Measurement of the t̄t production cross section in the all-jet final state in pp collisions at √s=7 TeV

A measurement is presented of the t̄t production cross section σt̄t in proton-proton collisions at a centre-of-mass energy of 7 TeV, in the all-jet final state that contains at least six jets, two of which are tagged as originating from b quarks. The data correspond to an integrated luminosity of 3.54 fb-1, collected with the CMS detector at the LHC. The cross section is determined through an unbinned maximum likelihood fit of background and t̄t signal to the reconstructed mass spectrum of t̄t candidates in the data, in which events are subjected to a kinematic fit assuming a t̄t → W+bW-̄b → 6 jets hypothesis. The measurement yields σt̄t = 139±10(stat.)±26(syst.)±3(lum.)pb, a result consistent with those obtained in other t̄t decay channels, as well as with predictions of the standard model. © 2013 CERN for the benefit of the CMS collaboration.

Influence of risk behavior aggregation in different categories of physical activity on the occurrence of cardiovascular risk factors

Background: We aimed to verify the association of risk behavior aggregation in different categories of physical activity (PA) with the presence of cardiovascular risk factors (RF) employees at a public university. Method. We analyzed data of 376 employees, which were visited in their workplace for measurement of weight, height and questionnaires to identify the risk behaviors and risk factors. Chi-square test was used to analyze the association between the dependent and independent variables and binary logistic regression was used to construct a multivariate model for the observed associations. Results: Associations were found between the aggregation of following risk behaviors: smoking, alcohol consumption and physical inactivity, considered in different categories of PA, and the increase in RF, except for the presence of hypertriglyceridemia. Individuals with two or more risk behaviors in occupational PA category are more likely to be hypertensive (3.04 times) and diabetes (3.44 times). For the free time PA category, these individuals were 3.18 times more likely to have hypercholesterolemia and for locomotion PA, more likely to be hypertensive (2.42 times) and obese (2.51 times). Conclusion: There are association between the aggregation of two or more risk behaviors and the presence of cardiovascular RF. © 2013 Bernardo et al.; licensee BioMed Central Ltd.

Measurement of masses in the tt̄ system by kinematic endpoints in pp collisions at √s = 7 TeV

A simultaneous measurement of the top-quark, W-boson, and neutrino masses is reported for tt̄ events selected in the dilepton final state from a data sample corresponding to an integrated luminosity of 5.0 fb-1 collected by the CMS experiment in pp collisions at √s = 7 TeV. The analysis is based on endpoint determinations in kinematic distributions. When the neutrino and W-boson masses are constrained to their world-average values, a top-quark mass value of Mt = 173.9 ± 0.9 (stat)+1.7 -2.1(syst.) GeV is obtained. When such constraints are not used, the three particle masses are obtained in a simultaneous fit. In this unconstrained mode the study serves as a test of mass determination methods that may be used in beyond standard model physics scenarios where several masses in a decay chain may be unknown and undetected particles lead to underconstrained kinematics. © 2013 CERN for the benefit of the CMS collaboration.

Measurement of the Bs0→μ+μ- branching fraction and search for B0→μ+μ- with the CMS experiment

Results are presented from a search for the rare decays Bs0→μ+μ- and B0→μ+μ - in pp collisions at √s=7 and 8 TeV, with data samples corresponding to integrated luminosities of 5 and 20 fb-1, respectively, collected by the CMS experiment at the LHC. An unbinned maximum-likelihood fit to the dimuon invariant mass distribution gives a branching fraction B(Bs0→μ+μ-)=(3.0-0.9+1.0) ×10-9, where the uncertainty includes both statistical and systematic contributions. An excess of Bs0→μ+μ- events with respect to background is observed with a significance of 4.3 standard deviations. For the decay B0→μ+μ- an upper limit of B(B0→μ+μ-)<1.1×10 -9 at the 95% confidence level is determined. Both results are in agreement with the expectations from the standard model. © 2013 CERN. Published by the American Physical Society under the terms of the.

Modelo de avaliação de maturidade em gerenciamento de projetos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Measurement of the ZZ production cross section and search for anomalous couplings in 2l2l' final states in pp collisions at root s=7 TeV

A measurement is presented of the ZZ production cross section in the ZZ -> 2l2l' decay mode with l = e, mu and l' = e, mu, tau in proton-proton collisions at root s = 7 TeV with the CMS experiment at the LHC. Results are based on data corresponding to an integrated luminosity of 5.0 fb(-1). The measured cross section sigma(pp -> ZZ) = 6.24(-080)(+0.86) (stat.)(-0.32)(+0.41) (syst.) +/- 0.14 (lumi.) pb is consistent with the standard model predictions. The following limits on ZZZ and ZZ-gamma anomalous trilinear gauge couplings are set at 95% confidence level: -0.011 < f(4)(Z) < 0.012, -0.012 < f(5)(Z) < 0.012, -0.013 < f(4)(gamma) < 0.015, and -0.014 < f(5)(gamma) < 0.014.

Measurement of the t(t)over-bar production cross section in pp collisions at root s=7 TeV with lepton plus jets final states

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of the W+W- and ZZ production cross sections in pp collisions at root s=8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of the production cross section for Z gamma -> nu(nu)over-bar gamma in pp collisions at root s=7 TeV and limits on ZZ gamma and Z gamma gamma triple gauge boson couplings

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of the W-boson helicity in top-quark decays from t(t)over-bar production in lepton plus jets events in pp collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of the W+W- cross section in pp collisions at and limits on anomalous WW gamma and WWZ couplings

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)