Comprimidos de HPMC contendo nimesulida: preparação, caracterização e estudo dos mecanismos que regem a liberação do fármaco

The pharmaceutical innovations, such as the use of polymers to control drug release, create possibilities for a better action of the drug in the body, which causes a a more effective therapeutic effect and a safer treatment for the patient. In this work, were prepared and characterized matrix tablets of hydroxypropylmethylcellulose (HPMC) containing nimesulide as model drug to evaluate the performance as a controlled release system. HPMC, a cellulose ester, is a hydrophilic polymer that undergoes swelling, i.e., absorbs water and forms a gel layer controlling drug release. The characterization of powders was performed by analysis of particle size and morphology, density, compressibility index determination, flow properties and determination of swelling profile. The tablets were evaluated according to their physical parameters of quality and to the in vitro release of nimesulide, as well as the analysis of the mechanisms of drug release by appropriate mathematical models. The set of results showed that the HPMC/Nimesulide mixture exhibited satisfactory physical characteristics (size, shape, density and flow). The release profile demonstrated an effective control upon drug release in enteric environment and presented more correlation with Korsmeyer-Peppas’ and Weibull’s mathematical models, indicating that the release of nimesulide occurs through the relaxation of the polymer chains

Teoria do desenho de mecanismos: aplicações na teoria dos conflitos internacionais

O presente trabalho busca apresentar os conceitos principais referentes à Teoria do Desenho de Mecanismos e sua aplicação à Teoria dos Conflitos Internacionais, e como sua utilização pode solucionar alguns problemas referentes à metodologia mais utilizada na análise dos conflitos, baseada na Teoria dos Jogos tradicional. Através de uma análise game-free, estabelecem condições gerais para a resolução de conflitos entre países, sem a necessidade de estabelecer formas de jogo específicas. Desse modo, determinam-se resultados para qualquer equilíbrio de qualquer forma de jogo que envolva países em disputa. O trabalho segue apresentando a relação causal entre incerteza e incentivos para revelar de maneira desonesta informações privadas como causas fundamentais de guerra. Analisam-se separadamente as condições que levam à guerra em dois tipos de incerteza, constantemente discutidas na literatura de conflitos internacionais: incerteza em relação ao custo de guerra e em relação à força relativa. Os resultados são apresentados com a devida formulação matemática

Avaliação gastroprotetora da epicatequina e verificação de seus mecanismos de ação

The stomach is an exceptional organ, which functions are sterilize food ingested, form the primitive bolus, digest lipids and proteins, and to store food temporarily in the gastrointestinal tract. Its capacity of digesting food without digesting itself is amazing. This fact occurs due to innumerous protective substances adjacent to the gastric mucosa. When aggressive factors overwhelm the protective factors, a lesion in the gastric mucosa is formed. Lesions that reach the lamina propria are called gastric ulcers, which are classified macroscopically as openings on the gastric wall and; microscopically, as a gastric injury characterized with epithelial desquamation, mucosal hemorrhage, glandular damage and eosinophilic infiltration. The current therapy available is effective, although it causes collateral effects, therefore researching new drugs is necessary. This work aim to evaluate the gastroprotective effect of epicatechin against gastric lesions induced by absolute ethanol and non steroidal anti-inflammatory drugs which are the main causes of this disease currently, yet we aim to study the main mechanisms of action responsible for the gastroprotective effect. The results show that epicatechin has a significant macroscopic and microscopic gastroprotective effect against gastric injuries induced by ethanol and indomethacin, acting locally by augmenting gastric mucus secretion and it also acts via antioxidant system by holding total glutathione levels. Epicatechin’s gastroprotective mechanisms depend on the activation of sulfhydryl compounds and doesn’t depend on the NO-synthase enzyme

Fatores e mecanismos que influenciam a resistência em soja a Anticarsia gemmatalis Hübner e Spodoptera frugiperda (J. E. Smith)

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV

Qualidade da semeadura direta de milho com dois mecanismos de pressão no disco sulcador sob duas velocidades

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Extrato hidroetanólico das folhas de Eugenia Aurata e de Eugenia Punicifolia (HBK) inibe a migração neutrofílica por mecanismos distintos

Pós-graduação em Biociências - FCLAS

Reformas educacionais e avaliação: mecanismos de regulação docente

Our main concern was to investigate the forms and rationalities implicit in the social regulation/autonomy of the management processes of learning, historically established in the 1971 through 2002 educational reforms, via assessment guidelines of school performance in the state of São Paulo. We used a socio-historical approach, relying on speeches and official documents as our primary source and on studies and research work about teacher assessment and performance as secondary sources. As central categories we considered continuity and rupture in the patterns and mechanisms of social regulation/autonomy of educational work. The results help to clarify how educational policies, instituted in contexts of social reproduction/transformation, influence the management of educational processes within the school.

Mecanismos de toxicidade do fipronil em hepatócitos isolados de rato

Pós-graduação em Ciência e Tecnologia Animal - FEIS

Caracterização dos mecanismos de ação da imunoterapia intravesical com P-MAPA envolvendo as vias de sinalização dor receptores Toll-like (TLR) 2 e 4 na progressão do câncer de bexiga não-músculo invasivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aprendizagem da escrita por meio de jogos e brincadeiras: relação entre o desenvolvimento do simbolismo e os mecanismos da escrita

Written language is a form of communication between humans and, as is not acquired naturally, needs educational interventions systematized to be learned. However, the teaching of writing is still mechanically imposed on the student, and could make use of other features such as games and plays. As a result, this research we analyze the writing development of phases, the psychic functions present in its development and the construction of a paradigm games and games that can be used as auxiliary tools in the teaching of writing. We describe the operation of each and identify how they can be used in the classroom. The survey was conducted through a qualitative approach of empirical type. The data concluded that these instruments are not used in class and often writing has no social relevance for the child. We also conclude that some usage scenarios of play occurred among children, are not used for didactic purposes as an example of sign-symbol relationship by teachers to teach writing

As estratégias de coping e o impacto sofrido pela família quando um dos seus está em tratamento contra o câncer

The aim of the present study was to analyze the impact suffered by 40 people when discovering that one of their family members was diagnosed with cancer, to analyze their coping strategies and expectations towards the patient’s illness and future. The study made use of the Coping Strategies Inventory by Folkman and Lazarus. Results show that most of the patients’ caregivers are their married children, with an average age of 45.7 (dp=12.67), and gainfully employed. These family members reported the negative impact of the diagnosis, with the predominant feelings of sadness and fear of loss, even though they had a positive perspective about the future, expecting the patient’s recovery. As to the functional coping strategies, the most used were the resolution of problems, followed by social support; the least used was positive revaluation. As to the dysfunctional strategies, the most used ones were escape and avoidance and the least used was taking the responsibility for the illness. Conclusions are that despite suffering with the negative impact of the disease, the family members are optimistic about the patient’s future and seek to use strategies that solve the problem effectively, without blaming themselves for the patient’s illness.

Sociedade disciplinar e sociedade de controle: os campos nos quais se exercem, os mecanismos que se utilizam e os sujeitos que formam

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Comportamentos de coping no contexto da hospitalização infantil

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Avaliação dos mecanismos de endurecimentoda liga AISI 300M submetida a diferentes ciclos de transformações martensíticas

Pós-graduação em Engenharia Mecânica - FEG