Um Modelo Espacial para a Resposta Imunológica Adaptativa da Hepatite B

This paper proposed a two-dimensional spatial model to describe the adaptive immune response for viral hepatitis B. This model considered six populations: healthy hepatocytes T, infected hepatocytes Y , hepatitis B virus V , innate immune system I, active immune system X and memory cells, X. First, a compartmental model was constructed and its equilibrium solutions and also the threshold values related to the stability of each solution were obtained. Using this model, we was able to reproduce the different trends observed for the disease, which are: individuals that eliminate the infection without forming immune response, patients with acute and chronic carriers. By including dispersion of defense cells of the immune system and virus (spatial model), we analyze two situations: homogeneous model, in which the model parameters are the same at all points of the network, and heterogeneous model, which characterizes cells more permeable and less permeable to virus invasion. For the two spatial models (homogeneous and heterogeneous) the times relatead to the viral erradication and/or virus invasion and persistence becoming smaller in relation to the compartmental model. The results also showed that for the set of values used in the simulations and if the two diffusion rates are different from zero, the model is sensitive to variations in the rate of viral spread and not dependent on the dispersion of memory cells. Finally, the heterogeneous model when compared to the homogeneous model shows that the infection can be spatially limited depending on the type of the cell involved in the infection process

Programação linear no planejamento do tratamento de câncer por radiocirurgia

Medical Physics has been reaching an important role among several lines in Science, providing means for the improvement of several theories and procedures. Currently, its main application is related with the use of ionizing radiations, specially, in treatment procedures such as Radiotherapy. Radiosurgery is a Radiotherapy technique which consists in administering a single tumoricidal dose of radiation exclusively to the tumorous lesion. It becomes then an interesting alternative to surgical treatment, mainly in cerebral metastases, which are the most frequent cerebral tumors in the central nervous system. The radio neurosurgical team works out a planning for the Radiosurgery treatment, aiming for obtaining an appropriate ideal treatment for each case. For the working out of this treatment planning, Computed Tomography images of the region to be treated are obtained, digitalized and later, fused with nuclear magnetic resonance images. Through these images, critical structures, organs at risk and lesions are localized. After this, calculations are made to determine three-dimensional positions of isocenters, isodose curves, prescribed dose, collimators sizes, position, numbers and respective weight of isocentric conformal fields, and others. The treatment planning is commonly based in desired levels of dose for specific types of tumors and organs at risk concerning the irradiated region. Theses levels of dose are chosen in a way that a high probability of cure may be achieved and meanwhile, that the probability of complications, in whichever organ at risk, may be minimal. Thus, many researches have been carried out, showing that mathematical techniques may help to obtain an optimal planning for the treatment of cerebral metastases. Among the methods of optimization in the study...(Complete abstract click electronic access below)

O estilo de João Ubaldo Ribeiro em Viva o Povo Brasileiros e An Invincible Memory

This paper aims at observing a particular case of an author’s and self-translator’s style in the pair of works Viva o Povo Brasileiro and An Invincible Memory. Our investigation has its theoretical starting point based on Corpus-Based Translation Studies (Baker, 1993, 1995, 1996, 2000; Camargo, 2005, 2007), and works on cultural domains (Nida, 1945; Aubert, 1981, 2006). The results showed that great part of cultural marks may be classified as the material, social, and ideological cultural domains, which reflects the context of the source text. It was also possible to observe that normalization features tends to reveal conscious or unconscious use of fluency strategies by the self-translator, making the translated text easier to read.

O estilo do rei: o diálogo entre O Rei Leão, da Disney, e Hamlet, de Shakespeare, sob uma perspectiva semiótica

This work consists of a semiotic analysis of the animation motion picture The Lion King (1994), by the Walt Disney Animation Studios, describing its intertextual relation with Hamlet, by Shakespeare, considering Disney’s individuality, its style. In order to study style in texts, we use discursive semiotics theory, highlighting Discini’s work (2013) and the concept of discursive settings. Hence, a deep discussion about The Lion King’s style, compared to the Shakespeare’s play, is established. The movie, once a syncretic text, requires advanced studies on Expression Plane, its plastic, musical and verbal/phonic aspects. We find these studies in the work of José Luiz Fiorin (2009), Lúcia Teixeira (2009), Ana Claúdia de Oliveira (2009), Jean-Marie Floch (2009) and Antônio Vicente Pietroforte (2008). We note how a syncretic text makes the discursive settings more complex by assembling plastic and sonorous materials in semissimbolic relation. Once defined The Lion King’s style, we analyze the way it justifies the intense popularity of this kind of animation features. Finally, it is important to understand how Disney uses in its style not only discursive settings, but also passional settings, revealing its own way to stir emotions on the spectator

Programação térmica fetal: efeitos sobre a temperatura de preferência e características morfofisiológicas de frangos de corte

Pós-graduação em Zootecnia - FCAV

Análise de Tópicos Relevantes em Programação Linear e Aplicações no Ensino de Engenharia

Pós-graduação em Engenharia Elétrica - FEIS

Desenvolvimento de um aplicativo de guia de programação de canais de TV digital

Pós-graduação em Televisão Digital: Informação e Conhecimento - FAAC

Otimização de sistemas de distribuição de energia elétrica radiais usando programação cônica de segunda ordem inteira mista

Pós-graduação em Engenharia Elétrica - FEIS

Uma proposta de sequência didática para o ensino de Programação Linear no Ensino Médio

Pós-graduação em Matemática em Rede Nacional - IBILCE

Programação térmica fetal e duração da fase de eclosão: efeitos sobre a qualidade na eclosão, variáveis sanguíneas, preferência térmica e resposta ao desafio térmico de pintos fêmeas

Pós-graduação em Zootecnia - FCAV

Programação por Metas, Análise por Envoltória de Dados e Teoria Fuzzy na avaliação da eficiência sob incerteza: aplicação em minifábricas do segmento de autopeças

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência do treinamento do kung fu estilo Garra de Águia na capacidade cardiorrespiratória em adultos

Introdução: O Kung Fu é um sistema de luta desenvolvida na China por meio de observações dos movimentos dos animais, e principalmente da necessidade dos monges praticarem alguma atividade física. Poucos estudos têm verificado os benefícios do Kung Fu não só como uma arte marcial, mas também como uma opção de exercício físico para quem busca uma boa qualidade de vida e melhora na aptidão cardiovascular através da filosofia de buscar a cada dia o extremo, a perfeição e o equilíbrio. Objetivo: Verificar a influência do treinamento de 12 semanas de Kung Fu estilo garra de águia em praticantes iniciantes adultos na capacidade cardiorrespiratória. Metodologia: Participaram do presente estudo 21 estudantes com idade entre 18 e 25 anos, divididos em grupo controle (n=10) e grupo treinamento (n=11). O grupo treinamento foi submetido a 12 semanas de treino e o grupo controle constituído por participantes que não praticavam atividade física de forma regular e que mantiveram sua rotina de vida normal. O protocolo de esteira rolante do teste de VO2 máximo foi utilizado antes e após 12 semanas. As aulas ocorreram duas vezes por semana na UNESP e tiveram duração de uma hora e meia cada aula, sendo dividida em quatro partes: aquecimento, condicionamento físico, alongamento e técnica. Para análise estatística, os dados foram separados de acordo com grupo e gênero. Devido à natureza paramétrica dos dados, foi realizada análise anova fatorial e adotado um p≤0,05. Todas as análises foram realizadas no programa estatístico SPSS. Resultados: O grupo controle apresentou os seguintes valores de Vo2pico: Masculino (n=6) - pré 38,8±8,0mL.kg−1.min−1 e pós 38,5±7,6mL.kg−1.min−1; Feminino (n=4) - pré 37,5±4,2mL.kg−1.min−1 e pós 38,0±4,1mL.kg−1.min−1. O grupo treinamento apresentou: Masculino (n=7) - pré 55,4±3,0mL.kg−1.min−1 e pós 55,3±3,7mL.kg−1.min−1; Feminino (n=4) - pré...

Modelo de programação não-linear para otimização do padrão de cultivo e retorno financeiro em áreas irrigadas

Pós-graduação em Agronomia (Irrigação e Drenagem) - FCA

Estilo de vida e saúde de um grupo de idosos de Franca, SP

The increase of elderly population in Brazil and all around the world shows the need of reviewing the health cares in order to get a better quality of life. Objective: To evaluate lifestyle and health care of elderly participants of UNATI, Franca, SP. Methods: Sixty elderlies answered a questions about socio-economic issues, health care, food consumption habits and lifestyle, after, they were submitted to anthropometric and laboratory tests. Results: There was a prevalence of women (85%), aged between 60-69 years old (60%), up to high school (60%), retired (65%), income up to 5 minimum wage (73.4%). Most seniors assessed medical care (65%) were in use of long-term medicines (78.3%), they reported to control blood pressure (80%) and to not smoke (100%). About 71.7% people believed to have a healthy diet, 97% took meals at home, 85% chose and prepared their own food, 65% had 5-6 meals/day, 63% drank 1L of water/day, 90% had bowel function and 43.3% practices a regular physical activity. Only 13.3% have done hormone replacement therapy, 18.3% take dietary supplements and 21.7% drink alcoholic drinks. The participants presented a BMI of 27.49 ± 4.5kg/m², prevalence of overweight and eutrophy, which values decreased with age. Leg circumference (LC) (36.27 ± 3.84 cm), Arm circumference (AC) (31.39 ± 4.08 cm) and triceps skinfolds (TS) (20.58±7.54mm) values were suit in most cases (96.7, 85 and 83.3%, respectively). Serum total cholesterol values were 198.53 ± 35.2mg/dL, 55% were considered optimum. About 63.3% and 68.3% of the elderlies, respectively, presented a high density lipoproteins (HDL) (53.58± 10.9mg/dL) and triglycerides (TG) (143.97 ± 92.37mg/dL) according to the recommendation and 51.7% of the elderlies had normal glycemia, 38.3% had risk and 10% showed high blood glucose, indicating diabetes. Conclusion: Many elderlies had body mass index (BMI) above normal, indicating overweight or obesity, but the participants can be considered healthy because of AC, LC and TS values, diet habits, health care and lifestyle.

Estrutura de conteúdos educativos para TV Digital: um modelo de referência

This paper proposes a model of educative content structuring for interactive digital television programs. Its intent was to provide references for collaborative production processes and content organization in learning networks associated with university and educative television broadcasting services. The model defines terms, actors, events, environments, as well as content categories, classes and attributes, indicating criteria for their synchronic or asynchronic association in a dynamic television schedule. The model is presented in both descriptive and visual formats, with the use of conceptual maps. The results indicate that interactive use of digital television in education requires systematic content models covering communitarian participation in both media production and distribution processes, in order to enhance learning instruments beyond vertical, hierarchical and centralized communication sustained by traditional broadcast channels.