Obtenção e caracterização de filmes de misturas de amido resistence e pectina como estratégia para liberação cólon específica de fármacos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A influência do acabamento da superfície interna do tanque no número de potência de novos impelidores

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Diretrizes metodológicas para o projeto de produtos de moda no âmbito acadêmico

Pós-graduação em Design - FAAC

Tratamento da ceratite infecciosa experimental em coelhos com o sistema de liberação controlada subconjuntival de ciprofloxacina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Desenvolvimento de nanopartículas de PLA e PLA-PEG para administração intranasal de zidovudina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Modificação de superfície empregando-se laser e recobrimento de implantes dentários de titânio com apatitas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Projeto e montagem de um sistema compacto de cogeração: aplicação da análise exergoeconômica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Plataformas bio(muco) adesivas poliméricas baseadas em nanotecnologia para liberação controlada de fármacos - propriedades, metodologias e aplicações

Studies using bio(muco)adhesive drug delivery systems have recently gained great interest, which can promote drug targeting and more specific contact of the drug delivery system with the various absorptive membranes of the body. This technological platform associated with nanotechnology offers potential for controlling drug delivery; therefore, they are excellent strategies to increase the bioavailability of drugs. The objective of this work was to study nanotechnology-based polymeric bio(muco)adhesive platforms for controlling drug delivery, highlighting their properties, how the bio(muco)adhesion can be measured and their potential applications for different routes of administration.

Interferência de sistemas de manejo na floresta nacional de Caxiuanã, PA nos atributos físicos e químicos na composição isotópica de solo antropizado

Pós-graduação em Agronomia (Agricultura) - FCA

In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Direct laser writing by two-photon polymerization as a tool for developing microenvironments for evaluation of bacterial growth

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nanostructured Lipid Carriers as a Strategy to Improve the In Vitro Schistosomiasis Activity of Praziquantel

Praziquantel (PZQ) is a pyrazinoisoquinoline anthelmintic that was discovered in 1972 by Bayer Germany. Currently, due to its efficacy, PZQ is the drug of choice against all species of Schistosoma. Although widely used, PZQ exhibits low and erratic bioavailability because of its poor water solubility. Nanostructured lipid carriers (NLC), second-generation solid lipid nanoparticles, were developed in the 1990s to improve the bioavailability of poorly water soluble drugs. The aim of this study was to investigate nanostructured lipid carriers as a strategy to improve the efficacy. of PZQ in S. mansoni treatment. We prepared NLC2 and NLC4 by adding seventy percent glycerol monostearate (GMS) as the solid lipid, 30% oleic acid (OA) as the liquid lipid and two surfactant systems containing either soybean phosphatidylcholine/poloxamer (PC/P-407) or phosphatidylcholine/Tween 60 (PC/T60), respectively. The carriers were characterized by nuclear magnetic resonance, differential scanning calorimetry, thermogravimetric analysis and Fourier transform-infrared spectroscopy. The safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. The results showed that the encapsulation of PZQ in NLC2 or NLC4 improved the safety profile of the drug. Treatment efficacy was evaluated on the S. mansoni BH strain. PZQ-NLC2 and PZQ-NLC4 demonstrated an improved efficacy in comparison with free PZQ. The results showed that the intestinal transport of free PZQ and PZQ-NLC2 was similar. However, we observed that the concentration of PZQ absorbed was smaller when PZQ was loaded in NLC4. The difference between the amounts of absorbed PZQ could indicate that the presence of T60 in the nanoparticles (NLC4) increased the rigid lipid matrix, prolonging release of the drug. Both systems showed considerable in vitro activity against S. mansoni, suggesting that these systems may be a promising platform for the administration of PZQ for treating schistosomiasis.

Eficiência energética em ar condicionado e refrigeração através da aplicação da termoacumulação

The use of refrigeration and air conditioning systems is of fundamental importance when it comes to air-conditioning of environments. Also important is the use of electricity for equipments’ operation related to these systems. Due to high cost of charging for this type of energy, factors economy and efficiency occupy key roles among design parameters of a system. One of the ways to get this economy is the use of a technique called thermal storage, or cold storage, which intends to move the required loads during peak time and also their equalizing, so that the energy is transferred from the peak time to non-peak time, thereby reducing the cost of energy consumed. Cold can be stored in the form of ice or ice water. This work aims to perform a technical-economic analysis of a mall located in Vale do Paraíba checking the feasibility of deploying a thermal storage system to achieve an economy in the cost of the energy used by the establishment. Through the parameters measured by the concessionaire of energy we can get the values of energy demand and power consumed, which will serve as basis for calculation for the study. The results obtained allow the development of two alternative proposals to the current configuration, one chosen by the criteria and results presented by technical-economic and energy analysis

PGCP - Plataforma para Gerenciamento Colaborativo de Projetos

Collaborative Systems are designed to support individuals in order to solve a problem together, or cooperatively (or collaboratively). Such systems have the advantage of not requiring the presence in the same location of the participants. The basis of any Collaborative System is communication, where users interact with each other in order to exchange information. Communication among individuals is accomplished through collaborative tools such as chat, email, document repository, etc.. Using these tools, companies can reduce operational costs, saving on travel and accommodation of its employees to attend meetings. The project members only need a computer with internet access to use collaborative tools. Project management is essential to the quality of the nal product. To perform a proper management, methodologies must be applied using methods, tools and procedures. There are some phases that are considered generic for all software process models, they are: de nition, development, maintenance and activity to support the software process. In this paper is described a platform for project management using the concepts and features of Collaborative Systems. The goal of this platform is to unify various collaborative tools (such as chat and document repository) in a project management system. Using the system, it becomes possible to manage projects, and the ability to maintain an active constant communication between members of each project

Proteção de sistemas eletricos industriais: relés e suas aplicações em subestações

Electrical installations in industries involving high currents and voltages considered. On the other side is the common appearance of electrical failures, caused by human error, defects in electrical equipment or electrical installation aging itself. These failures are varied, those with the highest rate of occurrence and cause much damage to electrical installations, are overcurrent and overvoltage. Therefore there is a need to project a system that can detect and minimize possible effects caused by faults in electrical installations industries. Protection systems in electric industries emerge as an alternative to control especially voltage and current magnitudes. Engineered based on the functions of the relays, protection systems are an indispensable tool for any industrial substation. But the project of such systems becomes increasingly more complex, due to technological development. Electrical equipment not develop at the same speed that the protective devices (relays), making it indispensable knowledge of integration of technologies