127 resultados para growth hormone deficiency


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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The aim of this study was to evaluate the response of dopamine in the growth hormone secretion (GH) during Nellore heifer's sexual maturation. The animals were randomly assigned into two experimental groups: Sulpiride group (dopamine D-2 antagonist, 0.59 mg/kg, S. C.) and control group (saline solution S. C.) at 8, 12 and 16 months of age. Blood samples were collected every 15 min for 10h after drug injection. Growth hormone was quantified by RIA, sensitivity (0.25 ng/mL) and intra and inter-assay variation coefficients were 15% and 17%, respectively. GH concentration was higher in sulpiride group than control group at 8 mo (10.1 +/- 0.38 ng/mL vs 4.3 +/- 0.34 ng/mL; P < 0.05) and 12 mo of age (9.46 +/- 0.35 vs 3.74 +/- 0.19 ng/mL; P < 0.05). In sulpiride group GH average concentration was greater at 8 and 12 mo compared to 16 mo of age (10.10 +/- 0.38 ng/mL and 9.46 +/- 0.35 ng/mL vs 4.87 +/- 0.35 ng/mL; P < 0.05) respectively. There was no difference between groups (P > 0.05) in total GH secretion area, total peak area and maximum peak amplitude. These results suggested an inhibitory dopamine effect on GH secretion in pre-pubertal Nellore heifers that decreases according to age.

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The benefits of proper nutrition and analgesia are closely linked when it comes to animals that are suffering from any illness and are hospitalized. In patients who are ill or under the stress of hospitalization, increase secretion of glucagon, catecholamines, cortisol and growth hormone antagonize the effects of insulin, leading to hyperglycemia and degradation of tissue proteins to provide substrate for gluconeogenesis. These changes result in loss of lean body mass, reflecting negatively on tissue repair processes, immune response and prognosis. Likewise, the pain induced by noxious stimulation can lead to protein catabolism, stress, immunosupression, delayed wound healing and acceleration of disease processes. This review confirms the nutrition and pain control importance in hospitalized patients, showing their physiological benefits and reduction in hospital stay when the clinician understands these benefits and the animals are treated with such care

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Pós-graduação em Microbiologia Agropecuária - FCAV

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Pós-graduação em Odontologia Preventiva e Social - FOA

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Forty-three animals of three genotypes, wich 13 Alpine (8 males and 5 females), 9 ½ Boer + ½ Alpine (4 males and 5 females) e 21 ¾ Boer + ¼ Alpine (11 males and 10 females), wich 21 received rbST and 22 control.The growth hormone used was the bovine recombinant somatotropin (rbST) and the animals of treatment 1 received the hormone in the adjusted amount from 0,3 mg/kg of live weight in intervals of 14 days. Animals of treatment 2 (control) had received saline solution in the same dosage and interval. There was no influence of the recombinant bovine somatotropin in the evaluated characteristics of performance. Males had been higher to females in weight gain of application of hormone to 120 days of age, as well as in daily average weight gain of 60 to 90, 90 to 120 and of application to 120 days of age. Weight to 90 and 120 days of age of females had been smaller in relation to males.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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The effect of ascorbic acid deficiency was determined in Piaractus mesopotamicus Holmberg, 1887, fish (pacu) under laboratory conditions. A total of 120 fish with an average body weight of 8.64 +/- 1.62 g and measuring 6.15 +/- 0.33 cm in length at the beginning of the experiment were fed diets containing 0, 50, 100 or 200 mg palmitate-coated ascorbic acid/kg dry ration for a period of 24 weeks with measurements every 4 weeks. The experiment was conducted in 20 fiber-cement aquaria of 81-liter capacity. Each aquarium was supplied with dechlorinated water at a flow rate of 1 l/min. Water temperature was measured daily and pH, dissolved oxygen, alkalinity and water conductivity were determined weekly. A fully randomized experimental design was utilized, with 5 replicates of each treatment and 6 fish per aquarium. Ascorbic acid-supplemented fish presented significantly increased growth when compared to unsupplemented fish. Furthermore, unsupplemented fish presented a higher incidence of hyperplasia, hypertrophy and dysplasia of the bone cartilage of gill filaments. The gill lamellae of unsupplemented fish had twisted cartilage and an inflammatory infiltrate at the ends. Anorexia and increased handling stress were also observed in fish fed the unsupplemented diet. The present study suggests that 50 mg ascorbic acid/kg dry ration is sufficient to improve development of pacu fingerlings but the optimum level under aquarium conditions, determined by regression analysis, is 139 mg ascorbic acid/kg dry ration.

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The effect of boron (B) on cotton growth and fruit shedding may be due not only to physiological or biochemical effects, but also to vascular tissue malformation. This experiment investigated petiole and floral peduncle anatomical alterations and growth of cotton supplied with deficient and sufficient B in nutrient solution. Cotton (Gossypium hirsutum cv. 'Delta Opal') plants were grown in solutions containing 0, 1.5, 3.0, 4.5, and 6.0 mu mol L-1 of B from 22 to 36 d after plant emergence (DAPE). From 36 to 51 DAPE, B was omitted from the nutrient solution. Petioles from young leaves and floral bud peduncles (first position of the first sympodial) were sampled and the cross-section anatomy observed under an optical microscope. The number of vascular bundles of the petiole was decreased in B-deficient plants and the xylem was disorganized. Phloem elements in the peduncle vascular cylinder of B-deficient plants did not show clear differentiation. The few xylem elements that were formed were also disorganized. Modifications caused by B deficiency may have impaired B and photosynthate translocation into new cotton growth. Boron accumulation in the shoot of B-deficient plants suggested that there was some B translocation within the plant. It could be inferred that cotton growth would be impaired by the decrease in carbohydrate translocation rather than by B deficiency in the tissue alone.

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The knowledge of nutrient mobility is an important tool to define the best fertilizer management and diagnosis techniques. Patterns of boron (B) mobility in plants have been reviewed, but there is very little information on B distribution and mobility in cotton. An experiment was conducted to study plant growth and B distribution in cotton when the nutrient was applied in the nutrient solution or to the leaves, and when a temporary deficiency was imposed. Cotton (Gossypium hirsutum, Latifolia, cv. IAC 22) was grown in nutrient solutions where B was omitted or not for 15 days. Boron was applied to young or mature cotton leaves in some of the minus B treatments. Root growth decreased when the plants were transferred to B solutions, but there was a full recovery when B was replaced in the nutrient medium. Boron deficiency, even when temporary, reduced cotton shoot dry matter yields, plant height and flower and fruit set, and these could not be prevented by foliar application of B. Because of decreased dry matter production, leaves of deficient cotton plants actually showed higher B concentrations than non deficient leaves. This would be misleading when a mature leaf is sampled for diagnosis. If there is any B mobility in cotton phloem, it is very low.