Sistemas precursores de cristais líquidos mucoadesivos para administração bucal de curcumina no tratamento do câncer bucal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A support system that delineates location-choice sets for firms seeking office space

Factors influencing the location decisions of offices include traffic, accessibility, employment conditions, economic prospects and land-use policies. Hence tools for supporting real-estate managers and urban planners in such multidimensional decisions may be useful. Accordingly, the objective of this study is to develop a GIS-based tool to support firms who seek office accommodation within a given regional or national study area. The tool relies on a matching approach, in which a firm's characteristics (demand) on the one hand, and environmental conditions and available office spaces (supply) on the other, are analyzed separately in a first step, after which a match is sought. That is, a suitability score is obtained for every firm and for every available office space by applying some value judgments (satisfaction, utility etc.). The latter are powered by a focus on location aspects and expert knowledge about the location decisions of firms/organizations with respect to office accommodation as acquired from a group of real-estate advisers; it is stored in decision tables, and they constitute the core of the model. Apart from the delineation of choice sets for any firm seeking a location, the tool supports two additional types of queries. Firstly, it supports the more generic problem of optimally allocating firms to a set of vacant locations. Secondly, the tool allows users to find firms which meet the characteristics of any given location. Moreover, as a GIS-based tool, its results can be visualized using GIS features which, in turn, facilitate several types of analyses.

Diffusion of oxygen in some binary Ti-Based alloys used as biomaterials

Ti and its alloys are widely used as biomaterials. Their main properties are excellent corrosion resistance, relatively low elastic modulus, high specific strength, and good biocompatibility. The development of new Ti alloys with properties favorable for use in the human body is desired. To this end, Ti alloys with Mo, Nb, Zr, and Ta are being developed, because these elements do not cause cytotoxicity. The presence of interstitial elements (such as oxygen and nitrogen) induces strong changes in the elastic properties of the material, which leads to hardening or softening of the alloy. By means of anelastic spectroscopy, we are able to obtain information on the diffusion of these interstitial elements present in the crystalline lattice. In this paper, the effect of oxygen on the anelastic properties of some binary Ti-based alloys was analyzed with anelastic spectroscopy. The diffusion coefficients, pre-exponential factors, and activation energies were calculated for oxygen and nitrogen in these alloys.