DISTRIBUIÇÃO DOS ARENITOS NA BACIA DE TAUBATÉ – SP.

A Bacia de Taubaté é caracterizada pela heterogeneidade geológica, herança da tectônica do tipo rifte, que dividiu a bacia em compartimentos e condicionou a sedimentação, constituída por depósitos de leques aluviais associados à planície aluvial e sedimentos lacustres do tipo playa-lake. A distribuição dos arenitos na bacia foi estudada com a interpolação 3D da fácies arenito, identificada através das informações dos perfis de poços. A interpolação não apenas distingue, em subsuperfície, os depósitos relacionados às formações Resende e Tremembé, como também constata zonalidades locais nos compartimentos. Ao relacionar as feições estruturais do rifte com a interpolação realizada para os arenitos, foi possível inferir a distribuição dos arenitos entre três grupos. O primeiro grupo relacionado à fase rifte, o segundo a um evento de transição bem representado no Compartimento São José dos Campos e o terceiro grupo aos sedimentos depositados durante o Neógeno até o Recente.

Controle robusto chaveado de sistemas lineares variantes no tempo com aplicação em falhas estruturais

Pós-graduação em Engenharia Elétrica - FEIS

Entomological surveillance, spatial distribution, and diversity of culicidae (diptera) immatures in a rural area of the atlantic forest biome, state of sao paulo, brazil

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Perceptions of environmental change and use of traditional knowledge to plan riparian forest restoration with relocated communities in Alcantara, Eastern Amazon

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Cell cycle kinetics, apoptosis rates, DNA damage and TP53 gene expression in bladder cancer cells treated with allyl isothiocyanate (mustard essential oil)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

MRE11A and SKP2 genes are associated with the increased cytotoxicity induced by the synergistic effects of cisplatin and gemcitabine in bladder cancer cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

No Relationship between the Amount of DNA Damage and the Level of hMLH1 and RASSF1A Gene Expression in Bladder Cancer Cells Treated with Cisplatin and Gemcitabine

Tumor response to antineoplastic drugs is not always predictable. This is also true for bladder carcinoma, a highly recurrent neoplasia. Currently, the combination of cisplatin and gemcitabine is well accepted as a standard protocol for treating bladder carcinoma. However, in some cases, this treatment protocol causes harmful side effects. Therefore, we investigated the roles of the genes TP53, RASSF1A (a tumor suppressor gene) and hMLH1 (a gene involved in the mismatch repair pathway) in cell susceptibility to cisplatin/gemcitabine treatment. Two bladder transitional carcinoma cell (TCC) lines, RT4 (wild-type TP53) and 5637 (mutated TP53), were used in this study. First, we evaluated whether the genotoxic potential of cisplatin/gemcitabine was dependent on TP53 status. Then, we evaluated whether the two antineoplastic drugs modulated RASSF1A and hMLH1 expression in the two cell lines. Increased DNA damage was observed in both cell lines after treatment with cisplatin or gemcitabine and with the two drugs simultaneously, as depicted by the comet assay. A lack of RASSF1A expression and hypermethylation of its promoter were observed before and after treatment in both cell lines. On the other hand, hMLH1 downregulation, unrelated to methylation status, was observed in RT4 cells after treatment with cisplatin or with cisplatin and gemcitabine simultaneously (wild-type TP53); in 5637 cells, hMLH1 was upregulated only after treatment with gemcitabine. In conclusion, the three treatment protocols were genotoxic, independent of TP53 status. However, cisplatin was the most effective, causing the highest level of DNA damage in both wild-type and mutated TP53 cells. Gemcitabine was the least genotoxic agent in both cell lines. Furthermore, no relationship was observed between the amount of DNA damage and the level of hMLH1 and RASSF1A expression. Therefore, other alternative pathways might be involved in cisplatin and gemcitabine genotoxicity in these two bladder cancer cell lines.

Supplementary corpora lutea monitoring allows progestin treatment interruption on day 70 of pregnancy in non-cyclic recipient mares

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Integrated assessment of metal contamination in sediments from two tropical estuaries

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Efeitos toxicogenéticos e toxicogenômicos do Isotiocianato de Alila (óleo de mostarda) em linhagens celulares de carcinoma de bexiga

Pós-graduação em Patologia - FMB

Spatial heterogeneity affecting fish fauna in cascade reservoirs of the Upper Parana Basin, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Caracterização estrutural do Lineamento de Piúma e sua influência na porção norte da Bacia de Campos

The detailed study of the Brazilian continental margin basins became possible with the advancement of geophysical tools, with emphasis on seismic reflection. Characterizing the structural and stratigraphic elements of Brazil’s marginal basins they realized that there was a relationship with structures present on the adjacent continental basement. So many works began to be made to understand this relationship and know the major factors that influenced the evolution of the continental margin. The study area of this work includes the northern portion of the Campos Basin and the continental outcropping adjacent areas, which corresponds to the northern of Rio de Janeiro state and the southern of Espirito Santo state. This area stands an important structural feature of NW-SE direction with a projection to the Campos Basin called Lineamento de Piúma. The outcropping basement rocks belongs to the Ribeira Belt which was bonded to other mobile bands forming the continent Western Gondwana during the Brasiliano Cycle, which later fragmented giving rise to the Atlantic Ocean. The opening of the ocean results on the formation of the marginal basins of Brazil. These basins have continental, transitional and marine facies. On Campos Basin the continental phase resulted on the formation of horsts and grabens bounded by synthetic and antithetic faults. Continuing rifting formed the saline lakes that deposited siliciclastic and carbonate sediments. The transitional phase resulted on thick packages consist of evaporites (halite and anhydrite) that was deposited in lagoon environment, tectonically quiet arid and semi-arid. The marine phase it deposited siliciclastic and carbonate in the Campos Basin resulting in shales, marls, limestones, ritmito, turbidites, sandstones and others. The objective of this study is to investigate the possible continuation... (Complete abstract click electronic access below)

A cunha do ciclo de fácies do Grupo Guatá (Eopermiano) na margem sub-aflorante do norte paranaense

A wedge facies cycle it‟s a body of sedimentary rock, bounded above and below by unconformity and which represents a transgressive-regressive cycle of deposition. This cycle is formed by the following succession of facies: non-marine (N), transitional-coarse texture, and marine-fine texture; The objective of this study have been members of the sandstones and Triumph Siderópolis, seconded by rare calcareous sandstones and very thin limb Paraguaçu. Through analysis of facies in wells testified by CPRM, it was possible to group on facies successions and set the standard stacking. The Triunfo Member consists of three cycles of facies, lithology whose standard indicates a vertical arrangement ''type'' tuning up, other words, a component sandy bottom in the form of '' box'', followed by components sandy-clayey and clayey-carbonaceous (1st and 2nd cycle) and / or shale and limestone (3rd cycle), represented by the base member Paraguaçu. The first cycle only occurs on NF-5 wells and NF-6 in the form of Onlap channel dug in post-Itararé group. The cycle II also reaches wells NF-4 and NF-3 to the north, while the cycle III reaches the southern area, well NF-9. The member Paraguaçu, well PP-25 is predominantly clay-síltico, also stand out limestones and sandstones. The limestones are not coastal marine organisms probably connected with the algae and cyanobacteria, the sandstones are fine-textured, very thin and coastal deposition environment. The member Siderópolis, well NF-2 consists of a sandstone fluvial-estuarine deployed in the valley section, and succeeded by sandstones and siltstones bioturbed, they have linked the transgression of the Fm. Palermo

Micromorfologia e anatomia floral das seções neotropicais de Bulbophyllum Thouars (Orchidaceae, Asparagales): considerações taxonômicas e evolutivas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O objeto transicional pode ser uma pessoa? teoria e clínica

The objective of this work is to answer the question posed in the title, based on the texts of D. W. Winnicott. To this effect we addressed the origins of the concept of transitional object in the author’s work, the chronology of its first appearances, direct references to the topic and a discussion of a clinical case. Winnicott rarely referred to a person as being another person’s transitional object, and when he did so, he situated this experience in the field of pathology, and when referring to it, used such terms as “comforter object”, “fetish object” and “regressive object”. In contrast, the concept of transitional object is linked to an experience indicative of mental health, of transition between fusion and mother-baby separation, and of the personal and symbolic use of objects of the sensory field. Maintaining this conceptual specificity enables us to discriminate nuances in the evolution of the use of material objects by the child, and helps to guide anamnesis, diagnosis and the therapeutic process.