108 resultados para Superiority
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Pós-graduação em Reabilitação Oral - FOAR
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This 12-week study compared the efficacy and safety of a fixed combination of fluticasone propionate plus formoterol (FL/F) 250/12 mu g b.i.d. administered via a dry powder inhaler (DPI) (Libbs Farmaceutica, Brazil) to a combination of budesonide plus formoterol (BD/F) 400/12 mu g b.i.d. After a 2-week run-in period (in which all patients were treated exclusively with budesonide plus formoterol), patients aged 12-65 years of age (N = 196) with uncontrolled asthma were randomized into an actively-controlled, open-labeled, parallel-group, multicentre, phase III study. The primary objective was to demonstrate non-inferiority, measured by morning peak expiratory flow (mPEF).The non-inferiority was demonstrated. A statistically significant improvement from baseline was observed in both groups in terms of lung function, asthma control, and the use of rescue medication. FL/F demonstrated a statistical superiority to BD/F in terms of lung function (FEV1) (p = 0.01) and for asthma control (p = 0.02). Non-significant between-group differences were observed with regards to exacerbation rates and adverse events.In uncontrolled or partly controlled asthma patients, the use of a combination of fluticasone propionate plus formoterol via DPI for 12-weeks was non-inferior and showed improvements in FEV1 and asthma control when compared to a combination of budesonide plus formoterol. (Clinical Trial number: ISRCTN60408425). (C) 2013 Elsevier Ltd. All rights reserved.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Biociências - FCLAS
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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The imaging is essential to aid the diagnosis of horses that have performance decrease associated with any pain or clinical signs related to the vertebral column. Radiography is the first imaging examination performed in these cases, particularly for disorders affecting the cervical region. However, this technique has limitations when the study of subtle changes due to the overlapping of adjacent structures. Computed tomography is a new diagnostic method in Brazil for the study of bone disorders in horses, but it is of great diagnostic value associate with the radiographic examination in order to provide an accurate assessment of the study area, owing to superiority in image quality when compared to conventional radiography. The aim of this study is increase and update knowledge of diagnostic imaging available to investigate cervical disorders in horses.
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This dissertation has as main theme the discuss about how the use of mathematical models for process optimization. The current scenario of strong competition to conquer the consumer market necessitates the development of improvements to better performance of the process as a whole, is to reduce costs, increase efficiency or effectiveness. Thus, the use of methodologies to assist in this process is becoming increasingly viable. Methodologies developed in the past are being studied and improved. An example is the Desirability, the object of the present study, which was developed in the 80's and has been improved over time. To understand and study this methodology was applied to the desirability function in three instances, where it was used Design of Experiments (DOE), taken from scientific papers, using the Solver tool (Excel ®) and desirability (Minitab ®). Thus, in addition to studying the methodology, it was possible to compare the performance of tools used for optimization in different situations. From the results of this study, it was possible to validate the superiority of one of the models studied compared fairly
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This paper describes the prepositions sob and sobre in the Functional Discourse Grammar framework (HENGEVELD; MACKENZIE, 2008) aiming at checking their lexical or grammatical status on the basis of classification criteria postulated by Keizer (2007). The following aspects point to their lexical status : (i) they consist of an Ascription Subact; (ii) they contain a specific content on the vertical axis signaling inferiority and superiority position in relation to a limit; (iii) they are not required by any predicate, but they are predicates by themselves, which require complementation by an argument playing Reference semantic function; (iv) they may be combined with de, em, para and por; which are genuine grammatical prepositions; and, finally, (v) they are not subjected to any phonological process of reduction and fusion.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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This project developed microstructural characterization technics of commercial dualphase and multi-phasic (TRIP) steels that were provided by the automotive industry and are currently used as the raw material for the production of automobiles. Inserted in this context, there is the development of the advanced high strength steels in consonance with the ULSABAVC project, which aims the production of safe, economically viable and efficient in terms of fuel consumption vehicles for the 21st century. The micro-structural characterization of biphasic and multiphase steels was done by the identification and quantification of the coexistent phases. In this item, a special attention was given to the technics that were performed using optic microscopy and scanning electron microscopy. An important contribution to this work was the utilization of different alternative chemical reagents (Beraha, Heat-Tinting technics) in addition to the classical ones (Nital and LePera)already used conventionally by the UNESP's Group of Mechanical, Microstructural and Fractografic Characterization of Materials. The revealed microstructures were correlated with the materials' mechanical properties determined through traction tests, such as ultimate tensile strengths, yield strength and stretching important since the material has structural application in the automotive industry. As a result, it was observed the superiority concerning the studied mechanical properties for the biphasic and multiphasic steels when compared to the conventional carbon steels. Besides, it was perceived a large potential for the industrial scale utilization of the Heat Tinting technics in this field, seen its differentiation of the existent phases and easy reproducibility
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The Lais of Marie de France are a specific type of historical record about the medieval aristocratic society and enables us to decipher the hierarchies that govern the relationship between men and women in the period. As well explains Georges Duby, medieval society tends to present coated with a male character because, among other factors, its latent misogyny. Women were placed under male authority, convinced of their natural superiority , the men despised , mocked her sex , meanwhile feared them, after all, women were Eve’s daughters. So, Lais offer female images that cannot be ignored , since it express the author women’s idea. However , as we seek to demonstrate in this article, Maria of France reflects the representations of the Christian society aristocratic. One note here that this article does not aspire to reach the actual circumstances, but the historical significance of female images present in the Lais.
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The penis and prepuce of the stallion have a high bacterial load on its surface, forming a natural microbial flora that contaminates the semen during ejaculation. Bacterial growth in semen may cause a decline on sperm quality, viability, and fertility and predisposes the occurrence of endometritis in inseminated mares. Thus, the aim of this study was to evaluate the effect of penile wash before semen collection, the addition of different commercial skim milk-based extenders containing antibiotics (BotuSemen and INRA96), and the removal of seminal plasma by filtration on the quality, viability, and bacterial proliferation on fresh and cooled stallion semen. Animals that were never submitted to penile wash before semen collection tended to have lower bacterial contamination in the ejaculate. Semen samples extended in BotuSemen showed superiority in total motility, progressive motility, average path velocity, and rapid sperm and lower bacterial contamination in relation to semen samples extended in INRA96 after 24 hours of cooling. No difference was found in these parameters between the storage temperatures (5 degrees C and 15 degrees C). Furthermore, the removal of seminal plasma by filtration reduced the bacterial load in semen after cooling. In conclusion, the penile wash before semen collection tended to reduce the bacterial growth in fresh semen. The use of a semen extender with appropriate antibiotics and removal of seminal plasma by filtration were effective in reducing the bacterial contamination and preserved the quality of cooled stallion semen. (C) 2015 Elsevier Inc. All rights reserved.