DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

PURPOSE:To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency. METHODS:The study group consisted of 15 medical residents from Anesthesiology and Surgery areas, of both genders, mainly exposed to isoflurane and to a lesser degree to sevoflurane and nitrous oxide; the control group consisted of 15 young adults not exposed to anesthetics. Blood samples were drawn from professionals during medical residency (eight, 16 and 22 months of exposure to waste anesthetic gases). DNA damage was evaluated by comet assay, and antioxidant defense was assessed by total thiols and the enzymes glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT). RESULTS:When comparing the two groups, DNA damage was significantly increased at all time points evaluated in the exposed group; plasma thiols increased at 22 months of exposure and GPX was higher at 16 and 22 months of exposure. CONCLUSION:Young professionals exposed to waste anesthetic gases in operating rooms without adequate scavenging system have increased DNA damage and changes in redox status during medical residency. There is a need to minimize exposure to inhalation anesthetics and to provide better work conditions.

Factors associated with the prevalence of hypertension and control practices among elderly residents of São Paulo city, Brazil

The aim of this study was to analyze the prevalence of hypertension and control practices among the elderly. The survey analyzed data from 872 elderly people in São Paulo, Brazil, through a cluster sampling, stratified according to education and income. A Poisson multiple regression model checked for the existence of factors associated with hypertension. The prevalence of self-reported hypertension among the elderly was 46.9%. Variables associated with hypertension were self-rated health, alcohol consumption, gender, and hospitalization in the last year, regardless of age. The three most common measures taken to control hypertension, but only rarely, are oral medication, routine salt-free diet and physical activity. Lifestyle and socioeconomic status did not affect the practice of control, but knowledge about the importance of physical activity was higher among those older people with higher education and greater income. The research suggests that health policies that focus on primary care to encourage lifestyle changes among the elderly are necessary.

Scattered organization of the histone multigene family and transposable elements in Synbranchus

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Microsatellite Organization in the Grasshopper Abracris flavolineata (Orthoptera: Acrididae) Revealed by FISH Mapping: Remarkable Spreading in the A and B Chromosomes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Intrinsic organization of the suprachiasmatic nucleus in the capuchin monkey

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Chromosomal organization and evolutionary history of Mariner transposable elements in Scarabaeinae coleopterans

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Patterns of rDNA and telomeric sequences diversification: contribution to repetitive DNA organization in Phyllostomidae bats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Product-portfolio management: A framework based on Methods, Organization, and Strategy

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise da presença e articulação teórica da Catalogação de Assunto na literatura científica da International Society for Knowledge Organization ISKO: uma análise de domínio

Subject Cataloging is one of the processes of subject approach to information, beside indexing and subject analysis. In this sense, this research is a part of a broader project which analyses ISKO as an academic space that promotes a dialogical dimension among those theoretical questions. In this sense, it aims to analyze the presence of subject cataloguing in the discussions of knowledge organization as well as how the authors of such subject dialogue each other. Considering the questions, the full collection of ISKO and ISKO-Spain conference proceedings were analyzed in order to verify how present were subject cataloguing matters in those collections. It was possible to identify a group of 36 articles (27 from International ISKO and 9 from ISKO – Spain) whose references were bibliometrically analyzed in terms of documentary forms, average life, language and citation analysis. The results showed that the major ISKO and ISKO-Spain literature on subject cataloguing is based on journal articles, mostly published in English, presenting a relatively young average life (14 years for ISKO and 10 for ISKO-Spain).

Evolution and genomic organization of muscle microRNAs in fish genomes

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Challenges and opportunities for knowledge organization at the intersection with information technologies

In this paper we study the intersection of Knowledge Organization with Information Technologies and the challenges and opportunities for Knowledge Organization experts that, in our view, are important to be studied and for them to be aware of. We start by giving some definitions necessary for providing the context for our work. Then we review the history of the Web, beginning with the Internet and continuing with the World Wide Web, the Semantic Web, problems of Artificial Intelligence, Web 2.0, and Linked Data. Finally, we conclude our paper with IT applications for Knowledge Organization in libraries, such as FRBR, BIBFRAME, and several OCLC initiatives, as well as with some of the challenges and opportunities in which Knowledge Organization experts and researchers might play a key role in relation to the Semantic Web.

Postmodern archival science and contemporary diplomatics New approaches for archival knowledge organization

New information technologies and new forms of documentary production have led archivists to rethink the role of archival science in the so-called information age. Since the late 1980s, the principles, methods and concepts stated by the well-known manuals of the 19th and the 20th centuries have been reconsidered along with their application to the organic sets of document in the 21st century. In this new scenario of reformulation and reinterpretation regarding the perspectives on archival knowledge organization, two trends with different approaches have emerged in North America and Europe: postmodern archival science and contemporary diplomatics, respectively. The first one was introduced by Terry Cook, who proposed a reformulation of the basic concepts and the functional analysis method focusing on the process and context of document creation. The second approach originated in Italy and incorporated all the theoretical and methodological models of classic diplomatics. The studies following this new trend were disseminated by Luciana Duranti and aimed to ensure the production, access and use of the documentation generated in the present times focusing on document typology, as opposed by the postmodern approach. The purpose of this study is to elucidate the connection points and distinct features between the two trends concerning the organization of archival knowledge.

Aboutness in Fiction: Methodological Perspectives for Knowledge Organization

The subject analysis of narrative texts of fiction is complex; the methodological model of identification of concepts as elaborated for scientific texts is not applicable to fiction. It is proposed here that theoretical and methodological use of the Generative Trajectory of Meaning postulated by Greimas may contribute to the identification of aboutness in narrative texts of fiction.

Archival Classification and Knowledge Organization: Theoretical Possibilities for the Archival Field

The main goal of this study is to outline a possible relation between archival classification and knowledge organization theory. In this sense, we seek to contribute to the conceptual classification in Archival Science, since there is a lack of systematization about archival classification; not just classification, but even the study of historical and conceptual aspects of the discipline. In the context of knowledge organization there is a considerable amount of research on how to build classification schemes and indexing systems that can help contribute to and expand archival classification theory. In order to comprehend this vast field of theories and methodologies we construct a parallel comparing the classification concepts in both areas and analyzing these concepts.

Theoretical Referents in Knowledge Organization: A Domain Analysis of the Knowledge Organization Journal

Aiming at contributing to the epistemological characterization of the area of knowledge organization, our goal is to analyze the KO journal, since its creation in 1993, as a knowledge domain, from a nuclear community of the most productive and greater impact authors, analyzing the dialogue among citing authors and cited ones, and also the co-citations established by the citing authors. We worked with a corpus of 310 articles published between 1993 and 2011 produced by a total of 360 authors. The relatively more productive authors, a group geographically concentrated in Europe (37%), North America (44%) and Asia (19%), is clearly explained by the historical European origin of the ISKO and by an increasing North American presence along the years. Of the 33 most cited authors, 22 were co-cited in at least 6 works, which suggests that they are the theoretical referential nucleus of the area, in the studied journal. Finally, we observe that the area reveals theme cohesion and coherence in its production, enabling us to clearly visualize its theoretical referential nucleus and to confirm the role performed by the KO magazine as a catalyzing agent of international theoretical construction in the area.