108 resultados para Protocolos de avaliação de feridas


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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The efficiency of the topical use of a commercial product constituted by a herbal combination on the healing evolution of equine induced wounds was studied. A skin lesion in the shape of a square with 5cm sides was surgically produced on both sides of the buttocks of eight adult horses. One side was considered control and another one treated. Both control and treated sides were rinsed with water and neutral soap. Additionally, the wound on the treated side received the topical treatment with the herbal combination. Macroscopic and microscopic healing evolution of the wounds was evaluated and their areas were determined during the experimental period. There was statistical difference between wound areas. At the last evaluation, the average area of the control side was 0.70cm² and of the treated side was 1.23cm². The contraction of scar observed at 77 days was 97.57% for the control side and 95.59% for the treated side.

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The aim of this study was to evaluate the association between cryoprotectants little studied in Brazil such as dimethylformamide and trehalose amid thinner, using protocols of fast and slow defrosting. Three adult Labrador Retrievier male, healthy dogs, weekly submitted to one semen collection during five-weeks period, were used. The base diluent medium used in this study was tris-citrate added with 3% of dimethylformamide + 3% glycerol (D1), 3% dimethylformamide and trehalose (D2) and 4% glycerol (D3). At defrosting, half of the semen samples from each diluent medium was defrosted by rapid method in water-bath at 75 °C for seven minutes, followed by a new immersion at 37 °C for 1 minute. The other half of the samples was defrosted by slow method, in water-bath at 37 °C for 1 minute. The semen was evaluated for sperm progressive motility and vigor, besides membrane integrity. For this, the semen samples were submitted to either hyposmotic and membrane integrity tests of the plasmatic membrane and acrosome (fluorescence). The results indicated that the use of glycerol as cryoprotector in TRIS diluter provides greater efficacy in cryopreserving spermatozoa of the canine species, when compared to dimethylformamide associated with trehalose or glycerol.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Reabilitação Oral - FOAR

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Muitas plantas pertencentes à região do Cerrado têm sido empregadas no tratamento de diversas doenças, como é o caso da Byrsonima pachyphylla A. Juss. Esta espécie é uma árvore conhecida popularmente como murici e que faz parte da família Malpighiaceae. As folhas, raízes e cascas de espécies de Byrsonima são utilizadas pela medicina popular contra infecções intestinais, em feridas crônicas, afecções de boca e garganta e como adstringente. A literatura científica apresenta trabalhos que revelam atividade antibacteriana do gênero Byrsonima contra Staphylococcus aureus. Investigações fitoquímicas do gênero Byrsonima apontam a presença de taninos, flavonoides e catequinas. No estudo realizado, o extrato metanólico de folhas de B. pachyphylla foi fracionado por partição líquido-líquido utilizando água, acetato de etila e n-butanol. O extrato e as frações foram solubilizados em diluentes adequados e testados contra S. aureus, E. coli e H.pylori através da técnica de diluição em microplaca com determinação da concentração inibitória mínima (CIM). Uma das frações ativas (acetato de etila) foi fracionada através de cromatografia em coluna (CC). As frações obtidas foram agrupadas de acordo com a semelhança do perfil em cromatografia em camada delgada (CCD). Seis dessas frações foram testadas contra S. aureus pela mesma metodologia citada. O extrato e as frações acetato de etila, n-butanol e 98 foram submetidos à triagem fitoquímica e análises em CCD empregando fase móvel e reveladores seletivos para taninos. As frações n-butanol e acetato de etila apresentaram atividade antibacteriana contra S.aureus. O fracionamento da fração acetato de etila resultou em 98 frações, agrupadas em 15 pela semelhança em CCD. Das 6 frações testadas, 4 apresentaram atividade contra S. aureus, destacando-se a 98 que apresentou valor de CIM de 125 µg/mL, igual... (Resumo completo, clicar acesso eletrônico abaixo)

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Rheumatoid arthritis (RA) is a chronic illness with great potential to cause comorbidities resulting from cumulative inflammatory activities, and it contributes with the increase of disabilities and death of patients. It affects 1 to 2% of world population and usually occurs between 30 and 50 years of age. Among existing therapeutic options for the disease non-steroidal anti-inflammatory drugs (NSAIDs) still play an important part in the treatment, being widely used by patients to relieve pain and stiffness. However, this class of drugs causes many adverse gastrointestinal effects, such as dyspepsia, heartburn, nausea and vomit, and its use is one of the most common causes of peptic ulcers. Mangiferin (a glicosilated xanthone extracted mainly from the bark of Mangifera indica L.) is the main compound of an aqueous extract made from the bark stem of the mango tree. Previous studies conducted by our research group prove the anti-inflammatory action of mangiferin on an animal model of periodontitis, and its gastroprotective action has been described before. Considering these informations this study evaluated mangiferin’s potential on the treatment of RA and on gastric ulcer healing in animal models, and analyzed toxicity parameters to assure efficacy and safety of the compound as potential new drug for the treatment of the disease. RA was induced in rats by subcutaneous injection of bovine collagen and Freund’s complete adjuvant. This method presented low incidence of RA in rats, but we were able to induce the disease in 60 to 70% of the animals. Due to the wide use of NSAIDs and its potential to cause peptic ulcers, we induced gastric ulcer on arthritic rats to analyze mangiferin’s gastric healing effect. After 14 days of treatment we noticed small increase of the lesion area of animals treated with mangiferin or ibuprofen, when compared to the animals... (Complete abstract click electronic access below)