Dificuldades e alternativas encontradas por licenciandos para o planejamento de atividades de ensino de óptica para alunos com deficiência visual

Partial outcomes of a study aimed to verify future High School teachers performance during the development of a Teaching Practice undergraduate course. The student teachers were asked to plan, elaborate and teach, in a classroom situation, optics topics to a class which included visual handicapped pupils. Data analysis shows that the main difficulties found by the student physics' teachers are related to which approach will be used to perceive phenomena dependent on vision and also to the need to break away from traditional pedagogy.. On the other hand, as alternatives, future teachers have shown creativity in order to overcome passive aptitudes related to this educational problem, working out methodological strategies that do not require the knowing/seeing relation, as well as, emphasizing oral communication within the physics teaching context. Copyright by the Sociedade Brasileira de Física.

Planejamento agrícola e implantação de sistema de cultivo de cana-de-açúcar com auxílio de técnicas geoestatísticas

Sugarcane is one of the most important crops of the Brazilian agribusiness and this importance justifies the use of techniques that allow the implementation of cultivation systems capable of reducing the variability of soil characteristics and the establishment of efficient agricultural planning. The aim of the present work was the planning and implementation of cultivation systems for sugarcane using geostatistical techniques, in the Pereira Barreto region, SP. An area of 505 ha was mapped using the global positioning system (GPS) and a Digital Elevation Model was elaborated (MDE). Soil samples were collected for 0-0.25 m depth, in each 7 ha, for their chemical attributes and texture characterization. Data were analyzed by descriptive statistics and geostatistics. The determination of the spatial distribution of soil granulometric and chemical attributes allowed the allocation of the studied sugarcane varieties according to soil fertility and clay content. The kriging maps of soil granulometric and chemical attributes brought useful information to the establishment of production environments with different soil and crop managements. The identification of different environments by means of geostatistical techniques allowed the precise planning of the sugarcane cultivation, as well as the adequacy of fertilization practices and the allocation of suitable sugarcane varieties adapted to the conditions imposed by differences in the soil attributes.

Planejamento, síntese e avaliação farmacológica de compostos híbridos potencialmente ativos para o tratamento da anemia falciforme

Sickle cell disease (SCD) is a hereditary hemolytic anemia caused by the inheritance of one S hemoglobin gene from each ancestor. Patients with SCD present increased circulating levels of cytokines, including TNF-alpha (TNF-α). Hydroxyurea (HU) is the available therapeutically strategy for treatment; it acts as a source of nitric oxide and benefits patients by increasing the levels of fetal hemoglobin (HbF). Thus, within one research line that aims at finding new drugs, a series of compounds with TNF-α inhibition and nitric oxide donation properties have been synthesized in order to explore possible synergism of actions beneficial in the treatment of the disease. Six compounds were synthesized: five derivatives of organic nitrates and one of sulfonamide. The compounds, (1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl) methyl nitrate (compound I); (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethyl nitrate (compound II); 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound III);4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxybenzenesulfonamide (compound IV); 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound V) and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]ethyl nitrate (compound VI), were synthesized using linear synthetic methodology, with excellent overall yields. All compounds showed anti-inflammatory and analgesic effects with a reduction in 43%-65% of ear edema in mice and a reduction of 25%-42% of writhing induced by acetic acid. All compounds showed comparable reductions in the leukocyte infiltration capacity and ability to generate nitric oxide. The aryl compounds (III, IV and V) presented less mutagenic activity compared to compounds I, II and VI according to the salmonella mutagenicity assay (Ames test). Compounds IV and VI showed activity in K562 culture cells, with increases in gamma globin gene expression to levels higher than with hydroxyurea suggesting a potential to increase fetal hemoglobin. This data set characterizes new potentially useful drug candidates for the treatment of symptoms of sickle cell anemia.