97 resultados para P3 purinoceptor
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Introduction: Auditory Late Responses (ALR) assess central auditory processing by neuro electric activity of the auditory pathway and analyse the activities involved in cortical abilities of discrimination, attention and integration of the brain. Individuals withAsperger Syndrome experience changes in these skills, so it is important to research these potential this population. The objective of this paper was to describe the auditory late responses of two patients with Asperger Syndrome. Methods: The study included two male patients with Asperger Syndrome, of 7 and 12 years of age, treated in a study centre. The patients did not present any auditory complaint detected by an amnesis. The external auditory canal was inspected and audiological and auditory late responses assessed. After evaluation the components P2, N2 and P3 were analysed. Results: In both patients, the latency of the components P2, N2 and P3 were elongated in both ears. Regarding the amplitude of the P2 component, reduced values were found for the left ear of patient 1 and the right ear of patient 2. The N2 amplitude was reduced for both ears of patient 1 and only the right ear of patient 2. The two patients showed a decrease in the amplitude of the P3 only in the right ear. Conclusion:This study concludes that there were changes in the ALR results in both patients with Asperger Syndrome, suggesting alteration of the auditory function at the cortex level.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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água que abastece uma cidade se não for tratada pode tornar-se importante veículo de transmissores de doenças. O controle da qualidade é uma medida que visa, principalmente, garantir a saúde da população. O objetivo desta pesquisa foi avaliar a qualidade da água distribuída pelo sistema de abastecimento da cidade de Santa Lúcia – SP. A água proveniente desse sistema chega até as residências e, muitas vezes, é consumida sem nenhum tratamento doméstico complementar. A cidade de Santa Lúcia é abastecida por três poços profundos (P2, P3, e P4). Com o intuito de avaliar a qualidade da água captada desses poços e distribuídas para consumo humano foram coletadas amostras diretamente dos poços e de um ponto de consumo nas áreas abastecidas por cada poço. Foram feitas três coletas em cada ponto, em três diferentes épocas do ano. Realizaram-se análises físico-químicas e bacteriológicas em todas as amostras. As análises bacteriológicas foram feitas para determinação da presença de coliformes totais, E. coli e contagem padrão de bactérias heterotróficas em placa. As análises físico-químicas avaliaram cloro residual livre, fluoreto, turbidez, pH, cor aparente e sólidos totais dissolvidos. Duas amostras foram positivas para coliformes totais, apenas uma amostra coletada no poço 2 foi positiva para E. coli. Para bactérias heterotróficas todas a amostras apresentaram contagem em placa inferior a 500 UFC/mL. Todas as amostras estavam dentro do padrão determinado pela legislação para pH, turbidez e sólidos totais dissolvidos. Todas as amostras coletadas no poço 2 tiveram como resultado ausência de cloro residual livre, o mesmo resultado para os demais pontos na segunda coleta de amostras. Todas as amostras apresentaram fluoreto com valores abaixo do VMP estabelecido pela legislação brasileira porém apenas cinco com concentrações dentro da faixa estabelecida pela legislação do Estado de São Paulo ...
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Fonoaudiologia - FFC
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The authors have studied the effect of four staining agents on the optical properties of esthetic restorative materials through translucency tests. Two commercial brands of composite resins were used: Point 4 (Kerr) and Charisma (Heraeus-Kulzer). The liquids tested were: wine, cola, chlorhexidine solution and nicotine solution. The translucency was measured at different periods of time: P0 – before immersion (baseline), P1 - 1 h after immersion, P2 - 2 h after immersion and successively, P3 – 24 h after immersion up to a period of 7 weeks. ANOVA statistical analysis was applied to the data (p < 0.05). The results lead to the following conclusions: (1) Composite resins submitted to the tested immersion mediums were stained, (2) the lower percentage of translucency was observed for nicotine containing solution, (3) The percentage of translucency decreased with the period of immersion.
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Pós-graduação em Agronomia (Horticultura) - FCA
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We can notice in Brazilian literature —both past and contemporary— the presence of the historical novel in its several modalities which include traditional models but also contemporary formulations that break old models with irreverence. Among them are the historiographical metafictions (Hutcheon, 1991), which propose the rereading not only of history but also of literature itself. Therefore, in the large number of historical characters which are fictionalized by contemporary Brazilian historical novel in the last decades, this essay intends to discuss how Ana Miranda engages in reading the history of Brazilian literature through fiction in three of her novels. The first is Boca do inferno (1989), whose protagonists are two of the main representatives of Brazilian colonial barroque, Father Antônio Vieira and poet Gregório de Matos. Following the chronological order of protagonist writers, the next novel to be discussed is Dias & dias (2002), whose action is centered in Gonçalves Dias, a well known poet of national Romanticism. The third is A última quimera (1995), which makes an outline of Brazilian literature at the beginning of the 20th century, dealing with Augusto dos Anjos and Olavo Bilac. By inverting some traditional viewpoints, Ana Miranda proposes, as in a palimpsest, the rereading and discussion of the national literary cânon and its construction.
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INTRODUCTION: Behavioral and electrophysiological auditory evaluations contribute to the understanding of the auditory system and of the process of intervention. OBJECTIVE: To study P300 in subjects with severe or profound sensorineural hearing loss. METHODS: This was a descriptive cross-sectional prospective study. It included 29 individuals of both genders with severe or profound sensorineural hearing loss without other type of disorders, aged 11 to 42 years; all were assessed by behavioral audiological evaluation and auditory evoked potentials. RESULTS: A recording of the P3 wave was obtained in 17 individuals, with a mean latency of 326.97 ms and mean amplitude of 3.76 V. There were significant differences in latency in relation to age and in amplitude according to degree of hearing loss. There was a statistically significant association of the P300 results with the degrees of hearing loss (p = 0.04), with the predominant auditory communication channels (p < 0.0001), and with time of hearing loss. CONCLUSIONS: P300 can be recorded in individuals with severe and profound congenital sensorineural hearing loss; it may contribute to the understanding of cortical development and is a good predictor of the early intervention outcome.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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To evaluate the biochemical profile and protein concentration of whey from milk samples of healthy Murrah primiparous and pluriparous buffaloes, 30 female buffaloes were analyzed during a complete lactation. The animals were divided into three groups: G1 = 10 primiparous buffaloes, G2 = 10 pluriparous buffaloes with 2-3 lactations and G3 = 10 pluriparous buffaloes with > 3 lactations. The lactation period was divided into: early stage (I: 1-3 months of lactation), intermediate stage (T: 4-6 months of lactation) and final stage (F: 7-9 months of lactation). Before milk sampling, physical examination of the mammary gland, strip cup test and California Mastitis Test (CMT) were performed. After mammary quarters asepsis, 20mL of milk were collected monthly from each mammary quarter, during a complete lactation, in sterilized plastic bottles without preservative, in order to perform microbiological isolation, biochemical profile and protein electrophoresis in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and 30mL of milk from each mammary quarter were collect, in sterilized plastic bottles containing preservative bronopol to perform the somatic cell count (SCC). A total of 1,042 milk samples were collected from the experimental groups during lactation, of which 923 samples showed negative reaction to CMT and negative microbiological isolation and were selected to biochemical profile analysis and protein electrophoresis in SDS-PAGE. There were influence of parity order and stage of lactation in biochemical profile and protein concentration of healthy Murrah buffaloes'whey. Primiparous buffaloes (G1) showed higher gamma-glutamyltransferase (GGT: 2,346 U/L), alkaline phosphatase (ALP: 181 U/L), phosphorus (P; 56.6mg/dL), potassium (K; 32.0mg/dL) and alpha-lactalbumin (458mg/dL). Buffaloes with 2-3 lactations (G2) showed higher SCC (70,700 cells/mL) and higher concentrations of total protein (1.55g/dL), albumin (100mg/dL), magnesium (Mg; 8.80mg/dL), chlorides (Cl; 176mg/dL), iron (Fe; 10.7 mu g/dL), sodium (Na; 178mMol/L) and lactoferrin (59.5mg/dL). Bufalloes with > 3 lactations (G3) showed higher concentrations of total calcium (Ca; 41.8mg/dL), ionized calcium (iCa; 2.92mMol/L), immunoglobulin A (IgA; 1.32mg/dL), serum albumin (99.1mg/dL), immunoglobulin G (IgG; 49.7mg/dL) and beta-lactoglobulin (1,068mg/dL). During lactation it was observed increase in SCC, GGT, ALP, total protein, albumin, P, Mg, Cl, Na, lactoferrin, serum albumin, IgG and alpha-lactalbumin, as well as decrease in concentrations of Ca, Fe, iCa, K, IgA and beta-lactoglobulin in buffaloes'whey. The results may be used as reference for buffaloes and to support diagnosis and prognosis of diseases common to lactation periods.
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PrTX-I, a non-catalytic and myotoxic Lys49-PLA(2) from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), alpha-tocopherol and alpha-tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 angstrom resolution. All complexes crystals are isomorphous and belong to the space group P2(1) whereas native PrTX-I crystals belong to the P3(1)21.