Nasal Carriage of Staphylococcus aureus in Botucatu, Brazil: A Population-Based Survey

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nasal and systemic inflammatory profile after short term smoking cessation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Os registros não-convencionais da coda nasal em dados de EJA

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

As grafias não-convencionais da coda silábica nasal: análise de dados de EJA

Este artigo trata das grafias não convencionais da sílaba com coda nasal encontradasem textos escritos por jovens e adultos. Para a descrição desses dados de escrita, sãoconsideradas duas complexidades: (i) a fonético-fonológica da sílaba, particularmente doelemento nasal em coda, e (ii) a da representação ortográfica da nasalidade em português.Sob o aspecto fonético, a coda corresponde a uma redução de energia, o que pode tornar ossegmentos que preenchem essa posição da sílaba menos audíveis. Sob o aspecto fonológico,a coda pode ser vista como um constituinte não imediato da sílaba cujo preenchimento sofrerestrições. Sob o aspecto ortográfico, são três as possibilidades de registro da nasalidade:, como, respectivamente, em “campo”, “canto”, “maçã”. Argumenta-se que asgrafias não convencionais analisadas podem ser motivadas pelas características fonéticofonológicasdos enunciados falados (particularmente, da sílaba com coda nasal) e, também,pelas características das convenções ortográficas dos enunciados escritos (especificamente,as convenções para representação da nasalidade da coda). Defende-se que essas grafias nãosejam vistas como erros decorrentes da interferência da fala na escrita, mas como pistas darelação constitutiva dos enunciados falados e escritos.

Análise do processo de reparo de defeitos ósseos críticos em calvária de ratos preenchidos com osso autógeno ou Bone Ceramic: um estudo histométrico e imunoistoquímico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise tomográfica, histológica, histométrica e imunoistoquímica do beta tricálcio fosfato com osso autógeno em aumento do soalho de seio maxilar

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo comparativo do processo de reparo utilizando osso autógeno e beta-tricálcio fosfato em levantamento do assoalho do seio maxilar em humanos: análise tomográfica, histológica, histométrica e imunoistoquímica

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Preparation and Characterization of Chitosan Nanoparticles for Zidovudine Nasal Delivery

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento de nanopartículas de quitosana para adminstração nasal de zidovudina

Zidovudine (AZT) is the drug most commonly used in AIDS treatment, isolated or in combination with other antiretroviral agents, but it has certain limitations due to its therapeutic dose-dependent haematological toxicity. In addition, it has low oral bioavailability, since it undergoes pre-systemic metabolism. The nasal route has been used as an alternative route for drug administration, because it can promote its direct absorption to blood circulation, avoiding hepatic metabolism. However, this route presents as a factor limiting the mucociliary clearance mechanisms that remove quickly the formulation of the nasal cavity. To prolong the residence time of formulations, in this direction, has been proposed the development of mucoadhesive systems. Among the various existing systems, the use of chitosan (QS), as mucoadhesive polymer, has been widely exploited in the preparation of nanoparticles (NPs). The objective of this study was to develop and characterize QS’s NPs for intranasal administration of AZT. For both NPs have been developed by ionic crosslinking of QS with sodium tripolyphosphate (TPP). These NPs were characterized by studies of particle size distribution, zeta potential, morphology, mucoadhesion tests, assessing the ability of encapsulation of the drug and permeation profile of AZT. The evaluation of AZT in the NPs was determined by UV-Vis spectroscopy. Mucoadhesion measures were made using a texture analyzer, using a mucin disk and porcine mucous membrane , and permeation assay were conducted using porcine nasal mucous membrane adapted to the Franz cell. These results suggest that the systems in hand have great potential for nasal AZT administration

Estudo teórico da contribuição à dose de partículas secundárias geradas por Prótons de energias entre 100 e 200 MeV num Phantom de osso cortical

In proton therapy, the deposition of secondary particles energy originated by nuclear inelastic process (n, 2H, 3H, 3He and α) has a contribution in the total dose that deserves to be discussed. In calculations of plans implemented for routine treatment, the paid dose is calculated whereas the proton loses energy by ionization and or coulomb excitement. The contribution of inelastic processes associated with nuclear reactions is not considered. There are only estimates for pure materials or simple composition (water, for example), because of the difficulty of processing targets consisting of different materials. For this project, we use the Monte Carlo method employing the code MCNPX v2.50 (Monte Carlo N-Particle eXtended) to present results of the contribution to the total dose of secondary particles. In this work, it was implemented a cylindrical phantom composed by cortical bone, for proton beams between 100 and 200 MeV. With the results obtained, it was possible to generate graphics to analyze: the dose deposition relation with and without nuclear interaction, the multiplicity and percentage of deposited dose for each secondary particle and a radial dispersion of neutrons in the material

Estudo teórico da contribuição a dose de partículas secundárias geradas por prótons de energias entre 100-200 MeV num phantom de osso compacto

The contribution of the total dose due to deposition of secondary energy particles caused by nuclear inelastic processes (n, 2H, 3H, 3He and  ) in proton therapy is an opened problem and in discussion. In the calculations of plans implemented for routine treatment, the paid dose is calculated whereas that the proton loses energy by ionization and or coulomb excitement. The contribution of inelastic processes associated with nuclear reactions is not considered, mainly due to the difficulty of processing targets consisting of various materials. In this sense, there are only estimates for pure materials or simple composition (water, for example).This work presents the results of simulations by the Monte Carlo method employing the code MCNPX v2.50 (Monte Carlo N-Particle eXtended) of the contribution to the total dose of secondary particles. The study was implemented in a cylindrical phantom composed by compact bone, for monochromatic beams of protons between 100 and 200 MeV with pencil beam form

Influência de diferentes superfícies de implantes unitários com geometria do tipo hexágono externo, Platform Switching e Cone-Morse em osso tipo III e IV: estudo pelo método dos elementos finitos tridimensionais

Pós-graduação em Odontologia - FOA

Análise histológica e histomorfométrica do processo de reparo de defeitos ósseos em ratos diabéticos preenchidos com osso autógeno e recobertos por membrana de matriz óssea homógena ou por membrana de politetrafluoretileno

Pós-graduação em Odontologia - FOA

Avaliação da espessura do osso parietal como região doadora de enxertos ósseos.

Introduction: The study of graft donor sites, whether from the anatomical, physiological or morphological point of view, has become a topic of current interest, due to the increasing number of patients needing facial bone reconstruction for various reasons. Purpose: In view of the need to constantly improve surgical techniques for autogenous bone graft harvesting, still considered the best choice for facial bone reconstruction, this paper describes an anatomical study on dry skulls in order to evaluate the average thickness of the parietal bone. Material and Methods: Measurements of this bone were taken with a goniometer, at four previously defined points, in the region that is often used as a donor site, in 49 dry skulls (98 parietal bones). The results were evaluated using the T test. Results: Thickness was measured at four predetermined points. The mean values (Point A = 4898mm, B = 4517mm, C = 6185mm, D = 4280mm) show that the bone can be even thinner than previously reported in the literature in other studies of the same nature. The largest bone thickness is in the medial and posterior region. Conclusion: A knowledge of these anatomical characteristics is helpful in preventing possible surgical complications, as well as making it safer for the surgeon to remove this graft and providing more information on whether or not to indicate this region as a bone graft donor site.

Complicações Associadas aos Enxertos Ósseos Aposicionais com Osso Autógeno

Introdution: Tooth extraction results in alveolar ridge resorption due to the progressive reabsorption, which frequently is a limitating factor of dental implants treatment, in function of the insufficient bone height for execution, could be indicated the use of grafts for increase of the alveolar edge. However, the success of the bone graft requests the meticulous attendance of the clinical stages. Proposition: The objective of this research was to evaluate the postoperative complications associated to the autogenous bone grafts. Materials and Methods: Through a random retrospective analysis, 90 file records of patients submitted to the surgical procedure of autogenous bone graft in the period of January from 2000 to the March of 2008. A clinical record was elaborated with base in the necessary data for this evaluation. Results: About the file data analysis, 59 female with average of 49,42 years and 31 male with average of 47,90 years. The previous diseases most related were arterial hypertension, stomachache and diabetis. The smokers was noticed in 13,3% of patients. The donor site most used was a mandibular ramus. The postoperative complications in receiving area represented 17,8% of file datas analysed and in the donor site only one patient showed parestesis. Conclusion: Among the total analyzed files it was observed that the postoperative complications associated with the autogenous bone grafts represented 18,9% of the patients submitted to the procedure, more frequently affecting the receiving area, obtaining partial exposure of the bone graft and absence of inserted gingiva on vestibular cortical bone.