Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants

Purposes: The purposes of this study were to evaluate the influence of chronic stress (CS) on implant osseointegration and also to analyze whether alendronate (ALN) therapy could prevent these eventual stress-negative effects. Materials and Methods: Adult male Holtzmann rats were assigned to one of the four experimental groups: AL (ALN; 1mg/kg/week; n=12), ALS (ALN+CS; 1mg/kg/week; n=12), CTL (sterile physiological saline; n=12), or CTLS (sterile physiological saline+CS; n=12). After 58 days of drug therapy, the ALS and CTLS groups were exposed to CS, and 2 days later all animals underwent tibial implant installation. The animals were euthanized 28 days following the operative surgical procedure. Results: It was observed that the CTLS group presented an impairment of bone metabolism represented by lowest levels of bone-specific alkaline phosphatase and bone area fraction occupancy values. Furthermore, these animals presented a higher proportion of empty osteocytic lacunae. In contrast, the ALN therapy showed increased osseointegration and torque value parameters, regardless of stress exposition. Conclusions: Analysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects. © 2013 Wiley Periodicals, Inc.

Role of the bed nucleus of the stria terminalis in cardiovascular changes following chronic treatment with cocaine and testosterone: A role beyond drug seeking in addiction?

Neural plasticity has been observed in the bed nucleus of the stria terminalis (BNST) following exposure to both cocaine and androgenic-anabolic steroids. Here we investigated the involvement of the BNST on changes in cardiovascular function and baroreflex activity following either single or combined administration of cocaine and testosterone for 10 consecutive days in rats. Single administration of testosterone increased values of arterial pressure, evoked rest bradycardia and reduced baroreflex-mediated bradycardia. These effects of testosterone were not affected by BNST inactivation caused by local bilateral microinjections of the nonselective synaptic blocker CoCl2. The single administration of cocaine as well as the combined treatment with testosterone and cocaine increased both bradycardiac and tachycardiac responses of the baroreflex. Cocaine-evoked baroreflex changes were totally reversed after BNST inactivation. However, BNST inhibition in animals subjected to combined treatment with cocaine and testosterone reversed only the increase in reflex tachycardia, whereas facilitation of reflex bradycardia was not affected by local BNST treatment with CoCl2. In conclusion, the present study provides the first direct evidence that the BNST play a role in cardiovascular changes associated with drug abuse. Our findings suggest that alterations in cardiovascular function following subchronic exposure to cocaine are mediated by neural plasticity in the BNST. The single treatment with cocaine and the combined administration of testosterone and cocaine had similar effects on baroreflex activity, however the association with testosterone inhibited cocaine-induced changes in the BNST control of reflex bradycardia. Testosterone-induced cardiovascular changes seem to be independent of the BNST. © 2013 IBRO.

Que dança é essa?: uma proposta para a educação infantil

Pós-graduação em Artes - IA

A estética do BijaRi: em busca da permanência

Pós-graduação em Artes - IA

Regiões de estabilidade no sistema Plutão-Caronte

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Monitoramento de hosts em redes tcp/ip sobre base georreferenciada com métricas de qualidade

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Anatomia do aparelho reprodutor masculino de Dendropsophus minutus e Dendropsophus nanus (Anura, Hylidae) durante o ciclo reprodutivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação do potencial genotóxico e mutagênico de águas e sedimentos do rio Guaecá, São Sebastião - SP, após impacto de oleoduto da região

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Reproductive phenology and fruit production on a land bridge island in the brazilian atlantic forest

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Detecção de Crateras de Impacto em Imagens Digitais. Estudo de caso: Superfície de Marte

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estrutura e dinâmica sucessional de um fragmento de floresta estacional semidecidual com diferentes históricos de pertubação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A contribuição do pensamento de Rousseau na construção da antropologia como disciplina acadêmica no século XIX

Pós-graduação em Ciências Sociais - FFC

Consumir e descartar: análise da cobertura da Folha de S. Paulo e Jornal da Cidade no caso da proibição da distribuição das sacolas pláticas nos supermercados do Estado de São Paulo.

Pós-graduação em Comunicação - FAAC

Atenas 2004 na Internet: uma análise da cobertura jornalística das Olimpíadas pelos sites brasileiros

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O design na indústria moveleira brasileira e seus aspectos sustentáveis: estudo de caso no pólo moveleiro de Arapongas-Pr

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)