A NEW SPECIES of MINIATURIZED TOADLET, GENUS BRACHYCEPHALUS (ANURA: BRACHYCEPHALIDAE), FROM SOUTHERN BRAZIL

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer

Hypermethylation in the promoter region has been associated with a loss of gene function that may give a selective advantage to neoplastic cells. In this study, the methylation pattern of genes CDKN2A (alias p14, p14(ARF), p16, p16(INK4a)), DAPK1, CDH1, and ADAM23 was analyzed in 43 samples of head and neck tumors using methylation-specific polymerase chain reaction. In the oropharynx, there was a statistically significant association between hypermethylation of the DAPK1 gene and the occurrence of lymph node metastases, and in the larynx there was statistically significant evidence of an association between hypermethylation of the ADAM23 gene and advanced stages of the tumors. Thus, a correlation was observed between hypermethylation of the promoter region of genes DAPK1 and ADAM23 and the progression of head and neck cancer. (c) 2007 Elsevier B.V. All rights reserved.

Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Epigenetic Silencing of CRABP2 and MX1 in Head and Neck Tumors

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Gene expression analysis reveals novel altered genes in nasal polyps

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Differentially expressed genes in giant cell tumor of bone

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A systematic study of transfection efficiency and cytotoxicity in HeLa cells using iron oxide nanoparticles prepared with organic and inorganic bases

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fresh-frozen human bone allograft in vertical ridge augmentation: clinical and tomographic evaluation of bone formation and resorption

The aim of the current study is to evaluate fresh-frozen human bone allografts (FHBAs) used in vertical ridge augmentation clinically and by computed tomography, and to analyze the resulting bone formation and graft resorption. Sixteen FHBAs were grafted in the maxillae and mandibles of 9 patients. The FHBAs, which were provided by the Musculoskeletal Tissue Bank of Marilia Hospital (Unioss), were frozen at -80A degrees C. After 7 months, dental implants were placed and bone parameters were evaluated. Vertical bone formation was measured by computerized tomography before (T0) and at 7 months (T1) after the surgical procedure. Bone graft resorption was measured clinically from a landmark screw head using a periodontal probe. The results were analyzed by Student's t-test. Significant differences existed in the bone formation values at T0 and T1, with an average change of 4.03 +/- A 1.69 mm. Bone graft resorption values were 1.0 +/- A 0.82 mm (20%). Implants were placed with varying insertion torque values (35-45 Ncm), and achieved primary stability. This study demonstrates that FHBAs promote satisfactory vertical bone formation with a low resorption rates, good density, and primary implant stability.

Sedimentation of the Cretaceous Bauru Group in São Paulo, Parana Basin, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O programa de pós-graduação em educação da UNESP de Marília: contribuições para uma agenda de discussões sobre aspectos da política de pós-graduação no Brasil

Apresentam-se parte dos resultados obtidos com as atividades de pesquisa desenvolvidas em nível de estágio pós-doutoral junto à Fundação Carlos Chagas, entre abril de 2009 e março de 2010, com o objetivo geral de identificar, reunir, analisar e interpretar os aspectos da Pós-Graduação em Educação da Faculdade de Filosofia e Ciências - FFC - Unesp/Campus de Marília (1988-2008) e suas contribuições para a Pós-Graduação no Brasil. Tal pesquisa se justifica considerando-se que, a avaliação dos aspectos da trajetória pregressa e da evolução de cada Programa de Pós-Graduação e seu contexto institucional, bem como as suas perspectivas de trajetória futura, concorrem para a história, para a redefinição e aperfeiçoamento dos aspectos da política de Pós-Graduação no Brasil. Particularmente neste texto, apresentamos os resultados dos trabalhos desenvolvidos mediante análise dos aspectos da configuração textual dos relatos orais de ex-partícipes do Programa que evidenciaram desafios que, historicamente, permanecem em aberto, dentre eles, os referentes ao desequilíbrio quanto à representatividade dos Programas das universidades estaduais com relação aos das estaduais nos órgãos colegiados centrais e à exigência de super especialização dos Programas quanto às suas propostas de investigação.