Development of organic-inorganic polymeric film formers for controlled drug release and wound care

Film forming polymeric systems represents a new and unexplored technology of systems forskin or wounds protection and for controlled drug release. The aim of this work was to study the use of polymeric organic-inorganic ureasil-polyether hybrids synthesized by the sol-gel process as film forming system containing silver sulfadiazine as model drug. The film formationtime can be controlled by changing the precursor/catalyst ratio used during the step of hydrolysis and condensations. The results showed that the precursor/catalyst proportion influences both the visual characteristics and time required to form the film. The precursor/catalyst ratio equal to 20.8 m/v was considered ideal due to promote the homogeneous and transparent film formation in less than 5 minutes. The release profile of sulfadiazine is dependent on the characteristics of the matrixes: matrix more hydrophobic as ureasil-POP provided a slowed released mainly due to the low swelling of the matrix. The more hydrophilic ureasil-POE matrix presents a large capacity to swell and favors the faster release of the drug. The set of results showed the possibility of future use of these systems for treating wounds caused by burns.

STORAGE OF Handroanthus umbellatus SEEDS

Seed storage under controlled environmental conditions represents one of the most important lines of research to be applied on short-lived forest species as Handroanthus. The present research aimed to identify the most suitable seed storage conditions and longevity behavior of Handroanthus umbellatus seeds subject to the following storage treatments: packaging permeable paper bags under a no-controlled laboratory temperature and humidity (control) and multiwall semipermeable bag at temperatures of -18 degrees C ,1 degrees C and 25 degrees C. Seeds were dried to 6.3% of water content. Stored seeds were evaluated every three months until 24 months for water content, germination percentage and vigor utilizing first counting test. Seeds of T. umbellata are orthodox, with low longevity under natural conditions, once they remain viable for less than 5 months. The best conditions of seed preservation of these species were obtained by storage at -18 degrees C in multiwall bags. Under these conditions physiological seed quality remains unchanged for a 24-month period.

Competência de juízo moral dos estudantes de medicina: um estudo piloto

The authors conducted a cross-sectional short-term study using Lind's Moral Judgment Test (MJT) to compare the moral judgment competence (C-score) among students in the first and eighth semesters from a medical school in the Northeast region of Brazil. This study also evaluated the influence of such factors as age and gender on moral competence. A difference equal to or greater than 5.0 points (absolute effect-size) on the C-score was considered significant. A regression of moral judgment competence among the students in their eighth semester in relation to the students in the first semester (C-score: 20.5 and 26.2 points, respectively) was observed. In the analysis of the students' performances in terms of MJT dilemmas, the phenomenon of moral segmentation was observed in both semesters, and the students performed better on the worker's dilemma than on the doctor's dilemma. Among students in the same semester of study, older students had lower C-scores. When comparing performance by gender, there was no significant difference between men's and women's C-scores. The finding of regression or stagnation in moral competence among the medical students demands deep reflection by those who work with the political-pedagogical projects of medical schools and by the entire faculty, in order to seek strategies to reverse this condition.

Estudo de doses e otimização de carta técnica na transição de radiologia convencional para computacional em diagnósticos veterinários

This project aims the verification of doses in canines and felines to chest and coxal exams due to the transition from screen-film to computed radiography system. It also seeks a possible optimization of the new techniques employed in this new system. The study was carried out in Diagnostic Imaging service in Hospital Veterinário da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo using a conventional x-ray equipment. Initially, data about the physical characteristics of animals and the technique currently used in computed radiography was collected for each of 80 chest and 16 coxal X-ray examinations. The animals were divided into different groups according to the body weight. For each group, were calculated the averages of each item: thickness of the region to be imaged, voltage, current, exposure time, current-time product, size of film used, presence or absence of bucky and focus (small or large). The techniques have been reproduced in phantoms (representative of the thickness of the animal) in order to collect the air kerma entrance. Based on the average of intermediate size M group (weights less than 5 kg for cats and from 10.1 kg and 20 kg for dogs) analysis of image quality using three devices test patterns were made consisting of the evaluation of spatial resolution, low-contrast resolution and contrast-detail. In general, the results showed the dose animals decreased with the use of computed radiography and was possible to preliminary optimization of some techniques used currently in CR

Análise citogenética clássica, molecular e ultraestrutural em escorpiões da família Buthidae: um enfoque evolutivo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cryptococcus: isolamento ambiental e caracterização bioquimica

Pós-graduação em Ciência Animal - FMVA

Tratamento compensatorio da má oclusnao de classe lll: revisão de literatura

Class III malocclusion is less common occlusal relationship, covering less than 5% of the population. There are various forms of treatment in Class III malocclusion. Depending on how the form is expressed Class III and age of the patient, the therapy may be orthopedic and orthodontic surgical orthodontics. The objective was to review the literature of the last 10 years about ways to compensatory treatment of Class III malocclusion. Several articles were published between 04/2003 and 04/2013 in the Pubmed database from the keyword "Class III malocclusion". However, only 19 articles that addressed the compensatory treatment of Class III were selected. Based on the selected items it was concluded that the treatment of Class III malocclusions in children before the peak of pubertal growth has better prognosis with greater effects orthopedic and orthodontic minor effects. The ideal treatment option for this condition is the Rapid maxillary expansion associated with maxillary protraction of the same. The treatment of Class III malocclusion in young people after the peak of pubertal growth is doubtful prognosis. You can opt to treat rapid maxillary expansion and maxillary protraction of the same or fixed appliance, however, orthopedic effects can be the same or smaller than the orthodontic effects, depending on the age of the patient. Depending on the degree of Class III malocclusion in adults, the treatment will consist of dental compensations or orthognathic surgery.

Auditoria em Saúde: justificativas de glosas no setor odontológico

Objective – To collecting data about the main explanations for glosses and demonstrating the percentage of production loss in the odontologic procedures. Methods – It is about an epidemiological study of historical series, retrospective and quantitative, based on the data collection of DATASUS information system and reports realized by the city of Aquidauana/MS audit system from 2001 to 2010. Results – The results show that in this period, 921.300 odontologic procedures were presented as production; being 223.226 (24,2%) individual procedures and 698.074 (75,8%) collective. There were 23.881 (2,6%) glosses, being 10.158 (42,5%) in the collective procedures and 13.723 (57,5%) in the individual ones. The main cause for glosses related to individual procedures was the repetition of procedures for the same patient and the same tooth (42,4%). In the collective activities, it was the non-accomplishment of the oral health collective program (68,9%). There was an increase of loss in the individual procedures going from less than 5% in the period of 2001 to 2007; to 5,8 % in 2008; 8,9% in 2009 and 14,1 % in 2010 and in the collective procedures the loss reached 4% in 2010. Conclusion – It was concluded that the most frequent cause of glosses explanation was the repetition of procedures for the same patient and the same tooth in the individual cases and the non-accomplishment of the oral health collective program in the collective activities. The importance of the audit system as a trust-worthy instrument for the managers in the planning and evaluation of health actions with the intention of guarantee the solution of the serv-ices provided.

Cryptococcus: isolamento ambiental e caracterização bioquímica

Cryptococcosis is an opportunistic fungal infection caused by Cryptococcus yeasts, especially C. neoformans and Cryptococcus gattii. The fungus is found in substrates of animal and vegetable origin, and infection occurs through inhalation and seedlings present in the environment. The present study aimed to investigate the existence of microfocus Cryptococcus sp. from the environmental samples of Araçatuba city, São Paulo, featuring new niches, by decoupling the direct relationship between fungus and host in order to minimize the risk of contamination of man and animals, understanding the ecoepidemiology of Cryptococcus. Fifty samples from hollows and tree trunks were harvested (Cassia sp., Ficus sp., Caesalpinea peltophorides) from ten representatives in the urban perimeter. The samples were immediately sent to the Laboratory of Bacteriology and Mycology, Faculty of Veterinary Medicine Araçatuba - Unesp where they were processed and plated on Petri dishes containing agar seed Niger and Sabouraud dextrose agar with chloramphenicol, incubated at 30ºC for a period of no less than 5 days. Afterwards they were subimitted to biochemical tests: urease production, thermotolerance at 37°C and quimiotipagem in CGB agar (L- Canavanine-Glycine-Bromothymol blue). The results showed that 17 (34%) cultures were positive for Cryptococcus, 9 (18%) for Cryptococcus gattii and 8 (16%) for Cryptococcus neoformans. Other yeast correlated as Rhodotorula sp. and Candida sp. were isolated. We conclude that the infectious propagules of Cryptococcus are dispersed in nature and constitute an environmental microfocus, not necessarily being bound to a single host.

Análise dos parâmetros antropométricos da cabeça dos militares da força aérea brasileira no projeto de capacetes balísticos

The study of the physical man characteristics and their variations have caught the man's interests since the ancient age. In Brazil, there are no studies which define the anthropometric profile of the Brazilian's head, hindering the development of ergonomic designs. One problem that occurs in the Brazilian armed forces is the use of protective helmets made with measurements of other countries, which causes great discomfort. Thus, this study aims to conduct a study to determine the anthropometric measurements of the head of the Brazilian Air Force military, assisting in the production of helmets more suitable. Therefore, it is presented ananthropometric survey in 576 students of the School of Aeronautics Expert, 286 females and 290 males, aged between 17 and 36 years. The study showed that the differences found between genders are less than 5%. In addition to the fact that the helmet Tues adjustments, there is no need for production of different helmets in relation to gender, but some changes are necessary measures in circumference and shape of the helmet.

A sewage sludge co-composting process using respirometric monitoring method in hermetic rotary reactor

This paper has the objective of monitoring the biological activity of composting process of sewage sludge, sugarcane bagasse and ground coffee in a hermetic rotary reactor using the respirometric method in laboratory scale, in order to obtain parameters and system design for large scale projects. Another particularity of this study is the use of a hermetic reactor with gas purging cycles. Purging was performed when the percentage of oxygen reached less than 5%, thus eliminating the gaseous mixture (with elevated CO2 ratio) and the introduction of environmental air with around 21% of O2, successively until the compost was stabilized. The average purge intervals obtained were 29 h and 2 min with reactor rotation frequency of 15 min. The time of the compost stabilization was optimized in 60% if compared to the 90 days in the traditional method. The results obtained can be used to design the process in industrial scale using a simple O2 gas analyzer.

Influência da infecção pelo HIV e do uso da terapia antirretroviral nas concentrações de selênio, selenometionina e proteção antioxidante

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Low Apgar scores at 5 minutes in a low risk population: maternal and obstetrical factors and postnatal outcome

OBJETIVO: Avaliar a associação entre índice de Apgar menor que sete no 5º minuto, os fatores pré-natais e resultados pós-natais. MÉTODOS: Trata-se de estudo retrospectivo com 27.252 recém-nascidos em maternidade escola com população de baixo risco obstétrico, de janeiro de 2003 a dezembro de 2010. Prontuários de todos os casos com índice de Apgar < 7 no 5º minuto (n = 121; - 0,4%) e de 363 casos com Apgar > 7 no 5º minuto, escolhidos ao acaso, foram revisados. Os principais desfechos estudados foram: óbito neonatal, insuficiência respiratória neonatal, necessidade de intubação orotraqueal e de unidade terapia intensiva (UTI) neonatal e encefalopatia hipóxico-isquêmica. RESULTADOS: Após análise de regressão múltipla, desacelerações tardias (DIP II) (OR: 2,4; IC95%: 1,4-4,1) e período expulsivo prolongado (OR: 3,3; IC 95%: 1,3-8,3) se associaram com Apgar < 7 no 5º minuto; assim como com insuficiência respiratória ao nascimento (OR: 3,0; IC 95%: 1,3-6,9), intubação traqueal (OR: 2,5; IC 95%: 1,2-4,8), necessidade de UTI neonatal (OR: 9,5; IC 95%: 6,7-16,8) e encefalopatia hipóxico-isquêmica (OR: 14,1; IC 95%: 3,6-54,7). Nenhuma outra variável prénatal se associou com Apgar < 7 no 5º minuto (p < 0,05). CONCLUSÃO: DIP II e período expulsivo prolongado estão associados com Apgar < 7 no 5º minuto em população obstétrica de baixo risco; situação essa relacionada com maior risco de insuficiência respiratória no parto, necessidade de suporte ventilatório e encefalopatia hipóxico-isquêmica.

APPLICATION OF WISDOMS PERTURBATIVE METHOD TO THE 5/2 AND 7/3 RESONANCES

Wisdom's perturbative method is applied to the 5:2 and 7:3 resonances. Some comparisons with Yoshikawa's model are performed: for values of eccentricity up to about 0.3-0.4, agreement exists and it is better for 5:2 resonance. A clear difference between the cases 5:2 and 7:3 is observed : the former one, like in the case 3:1, can show significant variations of eccentricity, even starting from very small values, close to zero, while the latter seems to undergo such variations, but with initial eccentricity not less than a value near 0.1.

Características principais de pacientes com PSA menor ou igual a 4,0 ng/ml, submetidos à biópsia de próstata guiada pelo ultrassom transretal

Pós-graduação em Bases Gerais da Cirurgia - FMB