O modo de vida just-in-time do novo perfil metalúrgico jovem-adulto flexivel do ABC: antigos dilemas, novas contradições e possibilidades

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Toxicidade e efeitos subletais de toxinas Cry de Bacillus thuringiensis Berliner em diferentes populações de Plutella xylostella (L.) (Lepidoptera: Plutellidae) em laboratório

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV

Injustiça e poder segundo Noam Chomsky

Injustice and power according to Noam Chomsky. In the beginning of the Politics, Aristotle establishes the two lesser forms of sociability: the relationships between man and woman and between master and the slave. In this context, he observes that “Hellenes are natural masters of barbarians” and the reason is that Greeks know philosophy and barbarians still resort to violence (ARISTOTLE, Politics, 1252a.). Shortly after defines “just war” as a war that has a fair cause, that is, which is well justified by philosophy or a fair speech (ARISTOTLE, Politics, 1255a.). This scene briefly expresses the manner in which the USA understands their role in the contemporary world. Chomsky points out the political use of massive military force of his country and denounces how it articulates internally and externally. He affirms that politics is excessively submitted to “ideology”, to doxa, as opposed to natural sciences. His militancy, thus, only advocates freedom and unrestricted right to information. In Camelot, the Kennedy years (1993), for example, the MIT’s professor collects information from congressmen’s speeches and government officials and from secret documents made public and he explicits the methods and actions of the US government. Thereby he can conclude that the US has, for historical reasons, an internal posture that is advocate or contrary to what they imposes to other countries. Power and justice on the one hand, force and injustice on the other –according to their own political discourse.

Ivabradine: Just another New Pharmacological Option for Heart Rate Control?

Ivabradine (IVB) is a heart rate lowering agent that acts via selective inhibition of the pacemaker funny current in sinoatrial nodal P cells, thus, reducing heart rate at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. IVB exerts no effect on external respiratory function parameters and it may also play a role in patients with concurrent chronic obstructive pulmonary disease. This property constitutes an important advantage over β-blockers. IVB acts by reducing the heart rate in a mechanism different from β-blockers, calcium channel blockers or late sodium channel blockers, three commonly prescribed antianginal drugs. As clinical trials have shown, it is remarkably well-tolerated and offers an alternative for patients who cannot take β-blockers. The combination of IVB and atenolol at commonly used doses in patients with chronic stable angina produced additional efficacy with no untoward effect on safety or tolerability. Additionally, side effects are rare and largely limited to a luminous phenomenon or phosphenes. This sensation is thought to be due to a block of Ih in the retina, a current very similar to cardiac If channels. IVB is contraindicated in patients with sick sinus syndrome or sinus node dysfunction and in patients taking hepatic inhibitors of Cytochrome P450 family 3, subfamily A, polypeptide 4 (abbreviated CYP3A4), with exception of omeprazole or lansoprazole. This review briefly summarizes the main studies regarding this drug.

M-CSF Priming of Osteoclast Precursors Can Cause Osteoclastogenesis-Insensitivity, Which Can be Prevented and Overcome on Bone

Osteoclasts and macrophages share progenitors that must receive decisive lineage signals driving them into their respective differentiation routes. Macrophage colony stimulation factor M-CSF is a common factor; bone is likely the stimulus for osteoclast differentiation. To elucidate the effect of both, shared mouse bone marrow precursor myeloid blast was pre-cultured with M-CSF on plastic and on bone. M-CSF priming prior to stimulation with M-CSF and osteoclast differentiation factor RANKL resulted in a complete loss of osteoclastogenic potential without bone. Such M-CSF primed cells expressed the receptor RANK, but lacked the crucial osteoclastogenic transcription factor NFATc1. This coincided with a steeply decreased expression of osteoclast genes TRACP and DC-STAMP, but an increased expression of the macrophage markers F4/80 and CD11b. Compellingly, M-CSF priming on bone accelerated the osteoclastogenic potential: M-CSF primed cells that had received only one day M-CSF and RANKL and were grown on bone already expressed an array of genes that are associated with osteoclast differentiation and these cells differentiated into osteoclasts within 2 days. Osteoclastogenesis-insensitive precursors grown in the absence of bone regained their osteoclastogenic potential when transferred to bone. This implies that adhesion to bone dictates the fate of osteoclast precursors. Common macrophage-osteoclast precursors may become insensitive to differentiate into osteoclasts and regain osteoclastogenesis when bound to bone or when in the vicinity of bone. J. Cell. Physiol. 229: 210-225, 2014. (c) 2014 Wiley Periodicals, Inc.

Methicillin-resistant Staphylococcus aureus of lineage ST398 as cause of mastitis in cows

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Atualidades no tratamento da laminite em equinos

Laminitis is still a major cause of lameness in horses, causing damage to many interested in it. It has been long studied, but there are several points that are not yet fully understood. Doubts about its pathogenesis end up extending at the treatments. Just as there are several theories that attempt to explain the mechanisms of its development, also appear treatments that are sometimes contradictory and inconsistent. Mostly times, laminitis is a consequence of another disease process that occurs systemically in the body. Among them are the main grain overload and processes that cause the animal to the table of endotoxemia, strangled colic, metritis with retained placenta and pleuropneumonia. The proposed treatments include the use of anti-inflammatory drugs, cryotherapy, use of vasodilators and correction of Starling forces, and other measures to support the frog. The stall should be bedded deeply with sand or other material that provides support to the frog

Diagnóstico ambiental da área de influência do distrito industrial de Rio Claro - SP

Economic activities, whether large or small, can cause a range of environmental changes, not always reversible, harming society and its quality of life. Many potentially polluting activities have already been installed in various Brazilian cities, just as at the industrial district of Rio Claro / SP, which allow the synthesis of the many environmental impacts. In this sense, this report aims to make an environmental assessment in the influence area of the industrial district of Rio Claro / SP, located in the urban area of the city. As a result, the existence of prior related studies was observed, especially the diagnosis and study of the many implications that arises from activities impacting, and further, there was a demarcation of the influence area of the district and its derivatives impacts in the influence area, the steps of prediction and mitigation measures and if these activities meet the minimum technical requirements in planning and environmental applicable legislation.

Detecção de outliers espaciais: refinamento de similaridade e desempenho

Pós-graduação em Ciência da Computação - IBILCE

Avaliação dos efeitos antitumorais de extratos brutos produzidos por fungos endofíticos isolados de Eugenia jambolana em células de hepatocarcinoma murino (Hepa-1c1c7)

Pós-graduação em Biociências e Biotecnologia Aplicadas à Farmácia - FCFAR

Distribuição de bivalve invasor Limnoperna fortunei (Dunker, 1857) na Bacia do Rio Prata após vinte anos (1991-2014) de sua introdução na America do Sul

Pós-graduação em Ciências Biológicas (Zoologia) - IBB

Tropical soils with high aluminum concentrations cause oxidative stress in two tomato genotypes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring

Ethnopharmacological relevance: Trichilia catigua is broadly used in folk medicine due to its mental and physical tonic activities and stimulant effects. In animal models, its antidepressant-like effects have been associated with the dopaminergic (DA) system modulation, which has an important role on maternal behavior and male offspring reproductive development.Aim of the study: Since little is known about the adverse effects of the exposure to T. catigua crude extract (CAT) in rats, specially regarding maternal homeostasis and offspring development, the aim of the present study was to evaluate whether CAT exposure may influence maternal toxicity parameters and behavior or disrupt male offspring physical and reproductive development.Material and methods: Dams were treated daily (by gavage) with 400 mg/kg of CAT or vehicle (control=CTR) throughout pregnancy and lactation. Fertility and maternal behavior tests were conducted in dams. Male offspring reproductive and behavioral parameters were analyzed.Results: Dams exposed to CAT showed increased pre- and post-implantation losses rates when compared to CTR group. No significant changes regarding maternal behavior or male offspring parameters were observed.Conclusion: In conclusion, maternal exposure to CAT interfered with implantation during the initial phases of pregnancy but did not induce changes on maternal behavior or male offspring reproductive and behavioral parameters.

Reduced knee flexion is a possible cause of increased loading rates in individuals with patellofemoral pain

Stair ascent is an activity that exacerbates symptoms of individuals with patellofemoral pain. The discomfort associated with this activity usually results in gait modification such as reduced knee flexion in an attempt to reduce pain. Although such compensatory strategy is a logical approach to decrease pain, it also reduces the normal active shock absorption increasing loading rates and may lead to deleterious and degenerative changes of the knee joint. Thus, the aims of this study were (i) to investigate whether there is reduced knee flexion in adults with PFP compared to healthy controls; and (ii) to analyze loading rates in these subjects, during stair climbing. Twenty-nine individuals with patellofemoral pain and twenty-five control individuals (18-30years) participated in this study. Each subject underwent three-dimensional kinematic and kinetic analyses during stair climbing on two separate days. Between-groups analyses of variance were performed to identify differences in peak knee flexion and loading rates. Intraclass correlation coefficient was performed to verify the reliability of the variables. On both days, the patellofemoral pain group demonstrated significantly reduced peak knee flexion and increased loading rates. In addition, the two variables obtained high to very high reliability. Reduced knee flexion during stair climbing as a strategy to avoid anterior knee pain does not seem to be healthy for lower limb mechanical distributions. Repeated loading at higher loading rates may be damaging to lower limb joints.