75 resultados para Heurística surrogate


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One of the reasons that influences the efficience of a port terminal that is especialized in movement of containers is in the process of their loading and unloading. The fundamental idea is to determine a plan, to each port in order to decrease the number of total movement of loading and unloading that are necessary during the ship route to every port so that they save time and consequently reduce costs. The goal of this research was to present improvement in the program, written in language C, used to solve to problem of loading and unloading of ships, a NP-complete problem, through the meta-heuristics Simulated Annealing. With the improvement made, an average of 50% reduction of necessary time was gotten to solve the problem in 45 analised instances and in a specific group of these instances the average reduction reached 77 and in 10 instances there was even an improvement in the solution

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One problem that has been happening frequently in port terminals is the poor planning of the loading and unloading of containers. The reason of this problem is the lack of an efficient method that provides the best means of these operations. The main goal of this work is, to implement a method that provides the best ways to perform the loading and unloading of containers, at each port and thus bring a great saving for these terminals, since the number of moves is directly proportional to cost. To carry out this program was used the idea that the containers are placed in vertical stacks, where the access can be done only by the top of the stack, so the ship was treated as an matrix and to fill it, two rules were created for loading and two for unloading. To obtain the best sequence of rules was used Beam Search method, which is an enumeration type implicit method that analyzes only the best solution of the tree generated. Thus, the program developed in the Java language, provides the best way to perform the loading and unloading ports and the way as the ship leaves each port using a graphical interface

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Air pollution is an environmental issue worldwide and frequently cause negative effects on population health and ecosystems on cities. The relationship between climate and atmospheric pollution can be used as a surrogate to the intensity of air pollution. The present and quantity of some gases can be used as indicators to air quality: particulate matter (PM), sulfur dioxide (SO2), carbon monoxide (CO), ozone (O3), and nitrogen dioxide (NO2). Among those gases, CO has its major source within the cities, where automobiles are the main emitter. But measure pollutant concentration are challenging, sometimes because the lack of good equipments due to high costs and of the large variability of models that varies in precision, way of measure and distribution of sellers. Modeling are useful when there are an intend to evaluate air pollution, its sources and evaluate scenarios. This work aims to use CAL3QHCR model developed by the U.S Environmental Protection Agency (EPA) to generate predictive surfaces of CO concentration distribution on a site within Campinas city, located in São Paulo state, Brazil. CAL3QHCR model use data urban automobile circulation to generate spatial results for CO distribution. We observed that the pollution concentration was lower on our modeling than the concentrations measured by Companhia Ambiental do Estado de São Paulo (CETESB), the main environmental company on the São Paulo state. Also the correlation between average estimates of our model and the measure by CETESB was weak, indicating that the model used on this study need to be or better parameterized, or the scale we measured of CO emissions need to be rescaled. Although the model failed to correlate to CETESB data, maybe one that explore the estimated emissions distributed within the sites to understand spatial distributions of CO on the regions. Also, the generated information can also be used to other studies, and come to be useful to explain heat island

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The Set Covering Problem (SCP) plays an important role in Operational Research since it can be found as part of several real-world problems. In this work we report the use of a genetic algorithm to solve SCP. The algorithm starts with a population chosen by a randomized greedy algorithm. A new crossover operator and a new adaptive mutation operator were incorporated into the algorithm to intensify the search. Our algorithm was tested for a class of non-unicost SCP obtained from OR-Library without applying reduction techniques. The algorithms found good solutions in terms of quality and computational time. The results reveal that the proposed algorithm is able to find a high quality solution and is faster than recently published approaches algorithm is able to find a high quality solution and is faster than recently published approaches using the OR-Library.

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Pós-graduação em Engenharia Elétrica - FEIS

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Engenharia Elétrica - FEIS

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BackgroundDiabetes is associated with long-term damage, dysfunction and failure of various organs, especially the eyes, kidneys, nerves, heart and blood vessels. The risk of developing type 2 diabetes increases with age, obesity and lack of physical activity. Insulin resistance is a fundamental aspect of the aetiology of type 2 diabetes. Insulin resistance has been shown to be associated with atherosclerosis, dyslipidaemia, glucose intolerance, hyperuricaemia, hypertension and polycystic ovary syndrome. The mineral zinc plays a key role in the synthesis and action of insulin, both physiologically and in diabetes mellitus. Zinc seems to stimulate insulin action and insulin receptor tyrosine kinase activity.ObjectivesTo assess the effects of zinc supplementation for the prevention of type 2 diabetes mellitus in adults with insulin resistance.Search methodsThis review is an update of a previous Cochrane systematic review published in 2007. We searched the Cochrane Library (2015, Issue 3), MEDLINE, EMBASE, LILACS and the ICTRP trial register (frominception toMarch 2015). There were no language restrictions. We conducted citation searches and screened reference lists of included studies.Selection criteriaWe included studies if they had a randomised or quasi-randomised design and if they investigated zinc supplementation compared with placebo or no intervention in adults with insulin resistance living in the community.Data collection and analysisTwo review authors selected relevant trials, assessed risk of bias and extracted data.Main resultsWe included three trials with a total of 128 participants in this review. The duration of zinc supplementation ranged between four and 12 weeks. Risk of bias was unclear for most studies regarding selection bias (random sequence generation, allocation concealment) and detection bias (blinding of outcome assessment). No study reported on our key outcome measures (incidence of type 2 diabetes mellitus, adverse events, health-related quality of life, all-cause mortality, diabetic complications, socioeconomic effects). Evaluation of insulin resistance as measured by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) showed neutral effects when comparing zinc supplementation with control (two trials; 114 participants). There were neutral effects for trials comparing zinc supplementation with placebo for total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (2 studies, 70 participants). The one trial comparing zinc supplementation with exercise also showed neutral effects for total cholesterol, HDL and LDL cholesterol, and a mean difference in triglycerides of -30 mg/dL (95% confidence interval (CI) -49 to -10) in favour of zinc supplementation (53 participants). Various surrogate laboratory parameters were also analysed in the included trials.Authors'conclusionsThere is currently no evidence on which to base the use of zinc supplementation for the prevention of type 2 diabetes mellitus. Future trials should investigate patient-important outcome measures such as incidence of type 2 diabetes mellitus, health-related quality of life, diabetic complications, all-cause mortality and socioeconomic effects.

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Background and ObjectivesHypokalemia has been consistently associated with high mortality rate in peritoneal dialysis. However, studies investigating if hypokalemia is acting as a surrogate marker of comorbidities or has a direct effect in the risk for mortality have not been studied. Thus, the aim of this study was to analyze the effect of hypokalemia on overall and cause-specific mortality.Design, Setting, Participants and MeasurementsThis is an analysis of BRAZPD II, a nationwide prospective cohort study. All patients on PD for longer than 90 days with measured serum potassium levels were used to verify the association of hypokalemia with overall and cause-specific mortality using a propensity match score to reduce selection bias. In addition, competing risks were also taken into account for the analysis of cause-specific mortality.ResultsThere was a U-shaped relationship between time-averaged serum potassium and all-cause mortality of PD patients. Cardiovascular disease was the main cause of death in the normokalemic group with 133 events (41.8%) followed by PD-non related infections, n=105 (33.0%). Hypokalemia was associated with a 49% increased risk for CV mortality after adjustments for covariates and the presence of competing risks (SHR 1.49; CI95% 1.01-2.21). In contrast, in the group of patients with K < 3.5mEq/L, PD-non related infections were the main cause of death with 43 events (44.3%) followed by cardiovascular disease (n=36; 37.1%). For PD-non related infections the SHR was 2.19 (CI95% 1.52-3.14) while for peritonitis was SHR 1.09 (CI95% 0.47-2.49).ConclusionsHypokalemia had a significant impact on overall, cardiovascular and infectious mortality even after adjustments for competing risks. The causative nature of this association suggested by our study raises the need for intervention studies looking at the effect of potassium supplementation on clinical outcomes of PD patients.

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Pós-graduação em Engenharia Mecânica - FEG

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Pós-graduação em Ciência da Computação - IBILCE

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Pós-graduação em Ciência da Computação - IBILCE

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Global competitiveness has been increased significantly in the last decade and, as consequence, companies are always looking for developing better processes in supply chain operations in order to maintain their competitive costs and keep themselves in the business. Logistics operations represent a large part of the product's final cost. Transportation can represent more than fifty percent of final cost sometimes. The solutions for cutting and packing problems consist in simple and low investment actions, as enhancing the arrangement of the transported load in order to decrease both material and room wastes. As per the presented reasons, the objective of this paper is to show and analyze a real application of a mathematical model to solve a manufacturer pallet-loading problem, comparing results from the model execution and the solution proposed by the company studied. This study will not only find the best arrangement to load pallets (which will optimize storage and transportation process), but also to check the effectiveness of existing modeling in the literature. For this study a computational package was used, which consists of a modeling language GAMS with the CPLEX optimization solver and two other existing software in the market, all of them indicating that an accurate mathematical model for solving this kind of problem in a two-dimensional approach is difficult to be found, in addition to a long execution time. However, the study and the software utilization indicate that the problem would be easily solved by heuristics in a shorter execution time

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Pós-graduação em Agronomia (Energia na Agricultura) - FCA