97 resultados para Exceed
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Pós-graduação em Zootecnia - FCAV
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Pós-graduação em Geografia - FCT
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Saúde Coletiva - FMB
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The aim of this study was to determine the no-observable-adverse-effect concentration (NOAEC) for trichlorfon, an antiparasitic agent used in aquaculture, in Piractus mesopotamicus (pacu) using acetylcholinesterase (AChE) activity as an end point. Fish were exposed 24 h/d for 15 d to different concentrations of trichlorfon in tanks of water for which a curve of dissipation was previously determined. Analysis of trichlorfon in water and fish plasma using gas chromatography with electron capture detection (GC-ECD) enabled measurement of limit of detection (LOD) and limit of quantification (LOQ), respectively, to be 3 and 10 ppb. Thirty-six hours after trichlorfon dilution in water, the concentration was below the LOD, and data showed that plasma concentrations did not exceed the LOQ. Apart from the 6.25 g/L, all concentrations of trichlorfon significantly inhibited plasma and brain AChE activity compared to controls. The AChE activity levels returned to control values in 7 d. These data may be useful to determine the concentration of trichlorfon that destroys parasites without producing adverse effects in fish.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Soybeans are an important food due to their functional and nutritional characteristics. However, consumption by western populations is limited by the astringent taste of soybeans and their derivatives which results from the action of lipoxygenase, an enzyme activated during product processing. The aim of this study was to evaluate the effect of gamma irradiation on the chemical composition and specific activity of lipoxygenase in different soybean cultivars. Soybeans were stored in plastic bags and irradiated with doses of 2.5, 5 and 10 kGy. The chemical composition (moisture, protein, lipids, ashes, crude fiber, and carbohydrates) and lipoxygenase specific activity were determined for each sample. Gamma irradiation induced a small increase of protein and lipid content in some soybean cultivars, which did not exceed the highest content of 5% and 26%, respectively, when compared to control. Lipoxygenase specific activity decreased in the three cultivars with increasing gamma irradiation dose. In conclusion, the gamma irradiation doses used are suitable to inactivate part of lipoxygenase while not causing expressive changes in the chemical composition of the cultivars studied. (C) 2014 Elsevier Ltd. All rights reserved.
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Rocuronium (ROC) is a neuromuscular blocking agent used in surgical procedures which is eliminated primarily by biliary excretion. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for analysis of ROC in human plasma. Separation of ROC and IS (verapamil) was performed using an endcapped C-18 column and a mixture of water:acetonitrile:trifluoracetic acid (50:50:0.1, v/v) as mobile phase. Aliquots of 100 mu L of human plasma were extracted at pH 3, using dichloromethane. The lower limit of quantification of 5 ng/mL shows the high sensitivity of this method. Intra- and inter-assay precision (as relative standard deviation) was all <= 14.2% and accuracy (as relative standard error) did not exceed 10.1%. The validated method was successfully applied to quantify ROC concentrations in patients under surgical procedures up to 6 h after the administration of the 0.4-0.9 mg/kg ROC. The pharmacokinetic parameter estimations of ROC showed AUC/dose of 563 mu g min/mL, total clearance of 2.5 mL/min/kg, volume of distribution at steady state of 190 mL/kg and mean residence time of 83 min. (C) 2013 Elsevier B.V. All rights reserved.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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This study attempts a preliminary assessment of the behavior of a soil improvement system with the use of encased columns of granular material with geosynthetic (columns Ringtrac ® ). This evaluation was performed using the software Ringtrac ® (developed by Huesker GmbH, Germany), which required different parameters such as soil Oedometric Module, friction angle of soil, thickness of soft soil and the embankment height .In each analysis, one parameter was varied and the other different parameters considered were fixed, resulting in a total of 726 results. Were considered valid only the results where the radial deformation of the geosynthetic encased column did not exceed the value of 4%, which is the maximum radial deformation of the geosynthetic adopted by the Ringtrac ® program. The analysis results are shown graphically in this study, evaluating the tension values in the column and obtained settlements in each analysis. It’s proven in this preliminary study that the variation of the soft soil friction angle in the Ringtrac ® column, will not significantly affect the values of strain on the tension in the column and settlements on the ground. Furthermore, the variation of Oedometric Module on the soil, will significantly affect the tension values in the column and the settlements in the soil
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Currently the market requires companies to adapt for they can have the lowest possible cost in their manufacturing, be it a good or service, thus obtaining a greater profit. For this profit the Toyota Production System applies lean manufacturing practices actions with reduced spending, smaller lots and stocks, generated by market demand. The technique allows SMED with few actions, changes and investments that time does not exceed one digit on your total time. This case study shows that only with standardization and use of inexpensive improvements, could reduce setup time on a machine for 70 minutes to time of approximately 48 minutes with little investment, demonstrating the viability of the tool presented
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Pós-graduação em Agronomia (Genética e Melhoramento de Plantas) - FCAV