83 resultados para Ends of Spaces


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special structures that cap chromosome ends to prevent degradation by nucleolytic attack and to distinguish chromosome termini from DNA double-strand breaks. With few exceptions, telomeres are composed primarily of repetitive DNA associated with proteins that interact specifically with double- or single-stranded telomeric DNA or with each other, forming highly ordered and dynamic complexes involved in telomere maintenance and length regulation. In proliferative cells and unicellular organisms, telomeric DNA is replicated by the actions of telomerase, a specialized reverse transcriptase. In the absence of telomerase, some cells employ a recombination-based DNA replication pathway known as alternative lengthening of telomeres. However, mammalian somatic cells that naturally lack telomerase activity show telomere shortening with increasing age leading to cell cycle arrest and senescence. In another way, mutations or deletions of telomerase components can lead to inherited genetic disorders, and the depletion of telomeric proteins can elicit the action of distinct kinases-dependent DNA damage response, culminating in chromosomal abnormalities that are incompatible with life. In addition to the intricate network formed by the interrelationships among telomeric proteins, long noncoding RNAs that arise from subtelomeric regions, named telomeric repeat-containing RNA, are also implicated in telomerase regulation and telomere maintenance. The goal for the next years is to increase our knowledge about the mechanisms that regulate telomere homeostasis and the means by which their absence or defect can elicit telomere dysfunction, which generally results in gross genomic instability and genetic diseases.

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Through deductions and formulations of the equations governing the behavior of plates elastic and thin based Kirchhoff theory, it is evident that it is justifiable to the complication of the numerical methods considering the complexity of the equations that describe the physical behavior of these elements and obtaining analytical solutions for specific situations. This study is directed to the application of the numerical method which is based on discretizations to the simplest elements which results in the reduction of data to be processed from. The numerical method in question is the Boundary Element Methods (BEM), as the name suggests, the discretizations are only the edges of the elements. The BEM converts the complex integral equations, in sums of functions that reduce the unknowns at the nodes that define the ends of discrete elements, obtaining internal values to elements using interpolation functions. Confirming the need and usefulness of the BEM, apply, then the foundations necessary to the specific cases of Civil Engineering where traditional methods do not provide the desired support, leaving in question the security situations and economics of the projects

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With the accelerated urbanization process of Brazil from the 50s, there was a disorderly occupation of spaces and consequent soil sealing. Unlike this growth, the support capacity of urban environments has not evolved in the same way, generating negative environmental impacts to the citizens. Among these impacts are the effects of flooding. In order to minimize the negative effects of extreme precipitation over cities, the government invests in corrective measures, like compensatory techniques on urban drainage, which have as a basic principle the retention and infiltration of the rainfall, dampening the peak flow and runoff. An example of applying these techniques in urban areas are the detention basins, commonly called large pools. The hydraulic design of these structures is dependent of complex data and variables, and projects involving small areas generally use simplified methods for defining the reservoirs volume of the storage (Tassi, 2005). One of these methods is presented in this study, which relates to the percentage of soil sealing to the specific storage volume (m³/ha) in combination by applying the hydrological model of the Rational Method and analyzing regional rainfall and soil occupation over the basin. Within this context, the basin of the Wenzel stream, which is located amidst the urban area of Rio Claro/SP, also presents the problems related to human occupation in its valley. Thus, by the method presented has been adjusted a curve correlating the percentage of impermeable area and the specific volume of a detention basin. For the current situation of Wenzel Basin with 82% of impermeable area, and return period of 10 years, the specific volume is 262.1 m³/ha. The presented method is consistent with the results of other studies in the area, and the expression obtained allows estimating the volume of storage required to match hydrograph pre and post-occupancy. It presents itself as a useful tool in the planning stage of...

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Questions of psychological interference have been white of the researchers, that identify in the emotional states, a key precious and important in the fight to get a significant result in the esportivo context. The present study it raised questions of interest of sciences of the sport, objectifying to check the influences of the emotional states of players of handebol and its possible interferences in the esportivo income. We work with a qualitative research, leading given next to the athletes and commission technique of the team of handebol of Sorocaba; using questionnaires structuralized and halfstructuralized for the collection of data. All the gotten results had been represented graphically and analyzed front to the theoretical referencial of the area. These results in had shown them that inside of the searched universe, consequentemente exist some factors that intervene with the esportivo income of the majority of the athletes , affecting in a generalized manner the income of the team. In this way we have that it is not only enough to give attention to the physical training, technician and tacticians. It is necessary to give a special attention to the psychological factors of the athletes, so that in a competition they can relieve everything that that has condition to relieve. Finally, we more suggest deepened research inside of this area so that let us can better understand and take attitudes with regard to subjects as the Daily paymenstrual Tension and the question of the leadership, in the form of case studies. We also suggest an intervention of work of a psychologist of the sport acting next to team since the phase of definition of objectives until the ends of the championship.

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In the recent years, the use of proton beams in radiotherapy has been an outstanding progress (SMITH, 2006). Up to now, computed tomography (CT) is a prerequisite for treatment planning in this kind of therapy because it provides the electron density distribution required for calculation of dose and the interval of doses. However, the use of CT images for proton treatment planning ignores fundamental differences in physical interaction processes between photons and protons and is, therefore, potentially inaccurate (SADROZINSKI, 2004). Proton CT (pCT) can in principle directly measure the density distribution needed in a patient for the dose distribution (SCHULTE, et al, 2004). One important problem that should be solved is the implementation of image reconstruction algorithms. In this sense, it is necessary to know how the presence of materials with different density and composition interfere in the energy deposition by ionization and coulomb excitation, during its trajectory. The study was conducted in two stages, was used in both the program SRIM (The Stopping and Range of Ions in Matter) to perform simulations of the interaction of proton beams with pencil beam type. In the first step we used the energies in the range of 100-250 MeV (ZIEGLER, 1999). The targets were set to 50 mm in length for the beam of 100 MeV, due to its interaction with the target, and short-range, and 70 mm for 150, 200 and 250 MeV The target was composed of liquid water and a layer of 6 mm cortical bone (ICRP). It were made 9 simulations varying the position of the heterogeneity of 5 mm. In the second step the energy of 250 MeV was taken out from the simulations, due to its greater energy and less interaction. The targets were diminished to 50 mm thick to standardize the simulations. The layer of bone was divided into two equal parts and both were put in the ends of the target... (Complete abstract click electronic access below)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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This text, homage to Ignacio Assis Silva, looks for the founding theoretical conceptions of his thoughts. When I looked at his texts, from the 70’s to the 90’s, my reading went through the path of an author who is always worried about revealing the birthplace of meaning. To catch this unique moment of semiosis, Silva proposes the concept of metamorphosis, a key-term which allows us to unite the two ends of his formation: Historical Grammar and Semiotic

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The concept of region raises two related historical problems. First of all, it concerns the epistemological accomplishment of regional history, since the need to provide a total history, one of the main challenges of the Annales movement, undergoes an impact with the notion of local, so that the overflight of the historic totality becomes nowadays an intensive totality. The historian who overflies the reality is replaced by the wanderer historian. In addition to this epistemological question, we can think about the historical feature of spaces. From an ontological point of view, according to the modes of its composition, as well as from the standpoint of its practical constitution, space can be either smooth or striated. These types of space belong to the Gilles Deleuze s nomadology and their definition might improve the characterization and description of historical spaces with regard to a certain contemporary historiographical movement known as the New Cultural History.Key Words: history;space;nomadism.