82 resultados para Covert Sensitization


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Biologia Geral e Aplicada - IBB

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Pós-graduação em Biopatologia Bucal - ICT

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Pós-graduação em Estudos Linguísticos - IBILCE

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A técnica de analgesia multimodal, por meio da infusão contínua de fármacos, pode ser empregada para diminuir a incidência de sensibilização central durante a anestesia. Avaliaram-se as características cardiorrespiratórias, durante o procedimento de artroscopia de joelho, em cães anestesiados com isofluorano e monitorados por meio do índice biespectral, submetidos à infusão contínua de morfina ou fentanil, associada à lidocaína e cetamina. Utilizaram-se 16 cães adultos, machos ou fêmeas, os quais foram distribuídos aleatoriamente em dois grupos, denominados MLK - que recebeu morfina (3,3μg/kg/min), lidocaína (50μg/kg/min) e cetamina (10μg/kg/min) ou FLK - em que foi substituída a morfina pelo fentanil (0,03μg/kg/min). Os cães foram pré-tratados com levomepromazina (0,5mg/kg IV), induzidos à anestesia com propofol (5mg/kg) e mantidos com isofluorano, ajustando-se a concentração para obterem-se valores de índice biespectral entre 55 e 65. As mensurações da frequência cardíaca (FC), dos parâmetros eletrocardiográficos (ECG), das pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), da tensão de dióxido de carbono expirado (EtCO2), da saturação de oxi-hemoglobina (SpO2), da frequência respiratória (FR) e da temperatura esofágica (T) iniciaram-se 30 minutos após a indução (M0) e continuaram após o início da infusão das soluções, em intervalos de 15 minutos (M15 a M75). Diferenças entre os grupos foram registradas para duração do complexo QRS (M60), para FC e T, entre M30 e M75, com MLK apresentando médias maiores que FLK, que registrou médias maiores que MLK para a SpO2 (M60), para os intervalos QT (M30 e M75) e RR (M0, M60 e M75). Concluiu-se que o emprego de morfina ou fentanil, associados à lidocaína e cetamina, promove efeitos semelhantes e não compromete as características avaliadas.

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In this article, we present different interpretations to the phenomenon of velar fronting, found in the speech of children. This phenomenon is discussed under both of the following paradigms: the symbolic one – which considers the existence of segments as sources of categorical representations – and the dynamic one, which not only considers different representational units, but also provides an alternative conception of what may be taken as a representation. The analysis focuses on acoustic data produced by children of about three years of age under controlled conditions in a ludic context. The results indicate that the subjects have a covert contrast between alveolars and velars that may be interpreted in light of at least three dynamic hypotheses.

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It has been demonstrated that, on abrupt withdrawal, patients with chronic exposure can experience a number of symptoms indicative of a dependent state. In clinical patients, the earliest to arise and most persistent signal of withdrawal from chronic benzodiazepine (Bzp) treatment is anxiety. In laboratory animals, anxiety-like effects following abrupt interruption of chronic Bzp treatment can also be reproduced. In fact, signs that oscillate from irritability to extreme fear behaviours and seizures have been described already. As anxiety remains one of the most important symptoms of Bzp withdrawal, in this study we evaluated the anxiety levels of rats withdrawn from diazepam. Also studied were the effects on the motor performance and preattentive sensory gating process of rats under diazepam chronic treatment and upon 48-h withdrawal on three animal models of anxiety, the elevated plus-maze (EPM), ultrasonic vocalizations (USV) and startle + prepulse inhibition tests. Data obtained showed an anxiolytic- and anxiogenic-like profile of the chronic intake of and withdrawal from diazepam regimen in the EPM test, 22-KHz USV and startle reflex. Diazepam chronic effects or its withdrawal were ineffective in promoting any alteration in the prepulse inhibition (PPI). However, an increase of PPI was achieved in both sucrose and diazepam pretreated rats on 48-h withdrawal, suggesting a procedural rather than a specific effect of withdrawal on sensory gating processes. It is also possible that the prepulse can function as a conditioned stimulus to informing the delivery of an aversive event, as the auditory startling-eliciting stimulus. All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam withdrawn animals without concomitant changes on the processing of sensory information

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Equine neonatal isoerythrolysis is a neonatal foals’ illness. Results from the incompatibility of blood type between the foal and the mare and mediated by maternal antibody absorbed by the colostrum against foal’s red blood cells. Characterized by a type ll hypersensitivity reaction, where the exhibition of the organism to a strange antigen, that it takes the sensitization of the lymphocytes B that after the removal of the antigens by the reticule-endothelial system the production of immunoglobulin is decreased, with the formation of cellular immunological will cause the occurrence of the illness in foal of sensitized mares. The most important clinical signs are severe anemia and jaundice, and this illness should be differentiated of other as: hemolysis induced by bacterial toxins, diseases of the hepatobiliary system, disseminated intravascular coagulation and incompatibility in blood transfusions. Like the sensitization happens during the previous incompatible foal’s birth, most cases occur in foals of multiparous mares. However during the first pregnancy the mare can generate a foal with neonatal 7 isoerythrolysis if she have developed placental anomaly in the beginning of the pregnancy which blood cells in her circulation

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From the twentieth century is witnessing a gradual increase in the debates and issues related to the degradation of nature, making the twenty-first century begins under the aegis of speeches linked to this concept as one of the axes of the concerns of humanity. There are several movements that are related to the degrading way of contemporary society and how we are called upon daily to save and defend nature, from the consumption of sustainable products through environmentally friendly lifestyles. While this may appear to be explicit that the current form of metabolic interaction man / nature in the current historical period of capitalism converges in a bleak scenario, however, there is an ideological and peacemaker convergence between productively and the systematic appeal to the consumption. Given these assumptions could be palpable the question that in the course of human history would be ideological conceptions of nature? Being a true statement what is the conflict present in the ideological struggle over nature with regard to the genesis of modern geography? Would it be overt or covert? These questions lead us to the present study, whose goal is to bring some notes about the ideological conceptions of the nature in human history, culminating in the possible influences upon the institutionalization of Modern Geography

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Pós-graduação em Química - IQ

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The present study focuses on the presence of covert contrasts in the speech of children with a phonological disorder. The hypothesis is that children with phonological disorders manipulate secondary acoustic cues in an attempt to distinguish the phonological contrasts. We used five audio recordings of the speech of five children with speech disorders, between four and five years of age, who showed the so-called “phonic substitution” involving the sound group of the fricatives. The data were edited and analyzed using the software PRAAT. A phonetic transcription of the first repetition of each child was performed by three evaluators, reaching a 66% agreement level. After the transcription, we carried out a contrastive phonological analysis of the production of the five children and, finally, an acoustic analysis of all the “substitutions”, based on six parameters. We discovered the existence of covert contrasts in the productions auditorily regarded as homophones by the evaluators, representing a total of 54% of total substitutions identified through an impressionistic approach by the evaluators. Children with phonological disorders are seen to rely on secondary acoustic cues in an attempt to distinguish fricative phonemes. The data obtained in this study allow us to reflect on the importance of considering the phonetic detail within the phonological models.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)