The reactivity of oytho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin

Redox processes are involved in the mechanism of action of NADPH oxidase inhibitors such as diphenyleneiodonium and apocynin. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy-substituted catechols as inhibitors of the NADPH oxidase in neutrophils and their reactivity with peroxidase. Aiming to alter the reduction potential, the ortho-methoxy-catechol moiety was kept constant and the substituents at para position related to the hydroxyl group were varied. Two series of compounds were employed: methoxy-catechols bearing electron-withdrawing groups (MC-W) such as apocynin, vanillin, 4-nitroguaiacol, 4-cyanoguaiacol, and methoxy-catechol bearing electron-donating groups (MC-D) such as 4-methylguaiacol and 4-ethylguaiacol. We found that MC-D were weaker inhibitors compared to MD-W. Furthermore, the radicals generated by oxidation of MC-W via MPO/H(2)O(2), but not for MC-D, were able to oxidize glutathione (GSH) as verified by the formation of thiyl radicals, depletion of GSH, and recycling of the ortho-methoxy-catechols during their oxidations. The capacity of oxidizing sulfhydryl (SH) groups was also verified when ovalbumin was incubated with MC-W, but not for MC-D. Since the effect of apocynin has been correlated with inactivation of the cytosolic fractions of the NADPH oxidase complex and its oxidation during the inhibitory process develops a special role in this process, we suggest that the close relationship between the reactivity of the radicals of MC-W compounds with thiol groups and their efficacy as NADPH oxidase inhibitor could be the chemical pathway behind the mechanism of action of apocynin and should be taken into account in the design of new and specific NADPH oxidase inhibitors. (c) 2007 Elsevier B.V. All rights reserved.

Eficácia do programa de remediação fonológica e leitura no distúrbio de aprendizagem

TEMA: Programa de Remediação Fonológica e Leitura no distúrbio de aprendizagem. OBJETIVO: verificar a eficácia terapêutica do Programa de Remediação Fonológica e Leitura em escolares com distúrbio de aprendizagem. MÉTODO: participaram deste estudo 40 escolares, sendo que estes foram divididos em: GI, subdivididos em GIE (10 escolares sem dificuldade de aprendizagem submetidos ao Programa de Remediação Fonológica e leitura), GIC (10 escolares sem dificuldade de aprendizagem não submetidos ao Programa de Remediação Fonológica e Leitura) e GII, subdividido em GIIE (10 escolares com distúrbio de aprendizagem submetidos ao Programa de Remediação Fonológica e Leitura), GIIC (10 escolares com distúrbio de aprendizagem não submetidos ao Programa de Remediação Fonológica e Leitura). Como procedimento foi aplicado o Teste de Desempenho Cognitivo-Linguístico, em situação de pré e pós-testagem antes da realização do Programa de Remediação Fonológica e Leitura. RESULTADOS: os resultados evidenciaram diferença estatisticamente significante entre os GIE e GIC e GIIE e GIIC indicando que os escolares submetidos ao programa obtiveram melhor desempenho em situação de pós-testagem se comparado a pré-testagem. CONCLUSÃO: a realização deste estudo evidenciou que o Programa de Remediação Fonológica e Leitura foi eficaz, pois proporcionou melhora na percepção, produção e manipulação dos sons e sílabas, interferindo diretamente na habilidade de leitura e compreensão dos escolares com distúrbio de aprendizagem.

Desempenho de escolares na adaptação brasileira da avaliação dos processos de leitura

TEMA: adaptação brasileira da avaliação dos processos de leitura (Prolec). OBJETIVO: caracterizar e comparar o desempenho de escolares do ensino básico público e privado de 1ª a 4ª séries na adaptação brasileira da avaliação dos Processos de Leitura (Prolec). MÉTODO: participaram deste estudo 262 escolares da 1ª à 4ª série do ensino básico, distribuídos em: Grupo I (GI), composto por 122 escolares de escola pública municipal e Grupo II (GII), composto por 140 escolares de escola particular. Como procedimento, aplicou-se a adaptação brasileira das provas de avaliação do Prolec. RESULTADOS: os resultados revelaram que o GII apresentou desempenho superior em provas de identificação de som, decisão lexical, leitura de palavras, leitura de palavras de baixa frequência, leitura de pseudo-palavras, compreensão de orações e compreensão de textos. Tanto os escolares do GI como do GII apresentaram desempenho abaixo da pontuação esperada nas provas do PROLEC na versão espanhola. CONCLUSÃO: a adaptação do Prolec para a realidade brasileira mostrou-se adequada para o estabelecimento de perfil de leitura nos escolares de ensino público e particular em fase inicial de alfabetização.

Relative expression of insulin like growth factor I (IGFI) and follicle stimulating hormone receptor (FSHR) in follicles and ovarian tissue from Bos primigenius indicus (Nelore)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The more stirring the better: cichlid fishes associate with foraging potamotrygonid rays

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Mitochondrial DNA variation in wild populations of Leporinus elongatus from the Paraná River basin

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Orthodromic transposition of the temporal muscle for facial paralysis: Made easy and better

The authors present a modified technique of transposition of temporal muscle for reanimation of facial paralysis. Fourteen cases illustrate the simplicity, advantages, and excellent esthetic and functional results of this method.

Knowledge Representation and Orthophemism: A Reflection Aiming to a Concept

Characteristics of speech, especially figures of speech, are used by specific communities or domains, and, in this way, reflect their identities through their choice of vocabulary. This topic should be an object of study in the context of knowledge representation once it deals with different contexts of production of documents. This study aims to explore the dimensions of the concepts of euphemism, dysphemism, and orthophemism, focusing on the latter with the goal of extracting a concept which can be included in discussions about subject analysis and indexing. Euphemism is used as an alternative to a non-preferred expression or as an alternative to an offensive attribution-to avoid potential offense taken by the listener or by other persons, for instance, pass away. Dysphemism, on the other hand, is used by speakers to talk about people and things that frustrate and annoy them-their choice of language indicates disapproval and the topic is therefore denigrated, humiliated, or degraded, for instance, kick the bucket. While euphemism tries to make something sound better, dysphemism tries to make something sound worse. Orthophemism (Allan and Burridge 2006) is also used as an alternative to expressions, but it is a preferred, formal, and direct language of expression when representing an object or a situation, for instance, die. This paper suggests that the comprehension and use of such concepts could support the following issues: possible contributions from linguistics and terminology to subject analysis as demonstrated by Talamo et al. (1992); decrease of polysemy and ambiguity of terms used to represent certain topics of documents; and construction and evaluation of indexing languages. The concept of orthophemism can also serves to support associative relationships in the context of subject analysis, indexing, and even information retrieval related to more specific requests.

Formulário do perfil psicossocial do paciente anoftálmico com indicação de prótese ocular

The patient with anophthalmia may present feelings of inferiority and rejection. Knowing his/her needs and expectations contribute to a better technical intervention. Purpose: To elaborate a questionnaire of the psychosocial profile of the patient with anophthalmia with indication of ocular prosthesis. Methods: An exploratory research was used to elaborate the questionnaire, by means of a guided interview followed by writing down what was said by the interviewees, who were adult patients of the Bucco-Maxillo-Facial Prosthesis Center of FOSJC - UNESP. The guided interview was made up of 14 items directly related to the future outline of the profile. Each item of the interview resulted in questions of the questionnaire, which was pretested twice before reaching its final version. Results: The patients reported, in the exploratory research, unpleasant feelings with the loss of the eye; relationship shyness; expectations regarding surgery and prosthesis use; a wish to receive explanations and to hold their opinion about the treatment. The questionnaire of the psychosocial profile of the patient with anophthalmia with indication of ocular prosthesis is, therefore, made of 43 questions divided into 5 blocks in order to aid the comprehension of the inquired aspects and to facilitate both the computation of data and discussion, and also to improve the selection of questions according to the objective of the researcher or professional. Conclusions: It was concluded that the questionnaire was viable, can be used in full or by selecting blocks and provide a panorama of the patient's history related to the problem he/she faces, from the loss of the ocular globe to the confection of the prosthesis.

Is 44-hour better than 24-hour ambulatory blood pressure monitoring in hemodialysis?

The aim of this study is to evaluate if hemodialysis (HD) patients with similar blood pressure (BP) in the whole inter-HD period could have different target organ lesions and survival if the behavior of BP differs from the first to the second day of the inter-HD period. The present study compares 44-hour ambulatory BP monitoring (ABPM) patterns in 45 HD patients. Three BP patterns emerged: group A (n = 15) had similar BPs throughout (138 ± 11/88 ± 12 in the first 22 h vs. 140 ± 11/87 ± 12 mm Hg in the second 22-hour period); group B (n = 15) had a significant systolic BP rise from the first to the second period (132 ± 15/80 ± 12 vs. 147 ± 12/86 ± 13 mm Hg, p < 0.05); group C (n = 15) had significantly higher BPs (p < 0.05) than the other 2 groups throughout the whole inter-HD period, with no significant change between the 2 halves (172 ± 14/108 ± 12 vs. 173 ± 18/109 ± 14 mm Hg). Ventricular mass and survival during the 30-month follow-up period were statistically significantly better in group A, intermediate in group B and worse in group C. The data suggest that a 44-hour ABPM is more accurate than a 24-hour one in evaluating organ lesion and prognosis in HD patients. Copyright © 2006 S. Karger AG.

Digital radiography for the inspection of weld seams of pipelines - better sensitivity

Conventional radiography, using industrial radiographic films, has its days numbered. Digital radiography, recently, has taken its place in various segments of products and services, such as medicine, aerospace, security, automotive, etc. As well as the technological trend, the digital technique has brought proven benefits in terms of productivity, sensitivity, the environment, tools for image treatment, cost reductions, etc. If the weld to be inspected is on a serried product, such as, for example, a pipe, the best option for the use of digital radiography is the plane detector, since its use can reduce the length of the inspection cycle due to its high degree of automation. This work tested welded joints produced with the submerged arc process, which were specially prepared in such a way that it shows small artificial cracks, which served as the basis forcomparing the sensitivity levels of the techniques involved. After carrying out the various experiments, the digital meth odshowed the highest sensitivity for the image quality indicator (IQI) of the wire and also in terms of detecting small discontinuities, indicating that the use of digital radiography using the plane detector had advantages over the conventional technique (Moreira et al. Digital radiography, the use of plane detectors for the inspection of welds in oil pipes and gas pipes.9th COTEQ and XXV National Testing Congress for Non Destructive Testing and Inspection; Salvador, Bahia, Brazil and Bavendiek et al. New digital radiography procedure exceeds film sensitivity considerably in aerospace applications. ECNDT; 2006; Berlin). The works were carried out on the basis of the specifications for oil and gas pipelines, API 5L 2004 edition (American Petroleum Institute. API 5L: specification for line pipe. 4th ed. p. 155; 2004) and ISO 3183 2007 edition (International Organization for Standardization, ISO 3183. Petroleum and gas industries - steel pipes for pi pelines transportation systems. p. 143; 2007). © 2010 Taylor & Francis.

To estimate the electric field near electric energy transmission systems by use simple software

The main objective this article is describe a methodology for the calculation of the profile of the electric field in the level soil and proximities originated by electric energy transmission systems real and in operation in the country. It also is commented the equation used and your computational implementation in order to agile and to optimize the studies. The results of simulations were just presented for the transmission system in the voltage class 500 kV for simplify the understanding and space restriction in the article, very although five others types of configurations have also been used in the complete study with very voltages and respective classes. The results were animating and very nearby of values well-known of electric field of other and publications traditional in the area. The graphic exits of program for better visual comprehension and understanding went in accomplished in the plan and in the space © 2010 IEEE.

A teoria de Norbert Elias: uma análise do ser professor

No presente artigo, conforme o entendimento de que modelos te- óricos subsidiam a compreensão de fenômenos investigativos, objetivou-se elucidar os conceitos da teoria sociológica de Norbert Elias, considerando-se que esta é uma excelente fonte de análise para se compreender o universo do ser professor, apesar de o autor não abordar diretamente questões relacionadas ao campo da educação. A partir do conceito de configuração, é possível dizer que a constituição do ser professor resulta das diferentes configurações nas quais ele está imerso, pois, de acordo com Elias, as pessoas (professores, pais, gestores, ministros, alunos etc.) modelam suas ideias a partir de todas as suas experiências e, essencialmente, das experiências vividas no interior do próprio grupo. É observável que as configurações, formadas por grupos interdependentes de pessoas, e não por indivíduos singulares, apresentam-se cada vez mais ampliadas nos contextos escolares, com funções especializadas e específicas (professores, alunos, diretores, coordenadores, supervisores, secretários etc.), em grupos que se tornam cada vez mais funcionalmente dependentes. As cadeias de interdependência estão mais diferenciadas e, consequentemente, mais opacas e dificilmente controláveis por parte de quaisquer grupos ou indiví- duos. Portanto, uma melhor compreensão será possível quando se estudar empiricamente as configurações que estão em jogo na educação brasileira. Daí se justifica a análise das configurações e das teias de interdependência em que os professores estão envolvidos. Enfim, a aplicação dos modelos de competição abordados por Elias possibilita evidenciar as problemáticas sociológicas do ser professor, tornando-as mais evidentes e facilitando o entendimento do jogo para reorganizá-lo em termos de equilíbrio na teia social.

When less is better: Insights from the product mix dilemma from the Theory of Constraints perspective

Perhaps due to its origins in a production scheduling software called Optimised Production Technology (OPT), plus the idea of focusing on system constraints, many believe that the Theory of Constraints (TOC) has a vocation for optimal solutions. Those who assess TOC according to this perspective indicate that it guarantees an optimal solution only in certain circumstances. In opposition to this view and founded on a numeric example of a production mix problem, this paper shows, by means of TOC assumptions, why the TOC should not be compared to methods intended to seek optimal or the best solutions, but rather sufficiently good solutions, possible in non-deterministic environments. Moreover, we extend the range of relevant literature on product mix decision by introducing a heuristic based on the uniquely identified work that aims at achieving feasible solutions according to the TOC point of view. The heuristic proposed is tested on 100 production mix problems and the results are compared with the responses obtained with the use of Integer Linear Programming. The results show that the heuristic gives good results on average, but performance falls sharply in some situations. © 2013 Copyright Taylor and Francis Group, LLC.