Undernutrition fetal programming: effects on kidney morphology, renal steroid and angiotensin receptors expression and urinary sodium excretion

Maternal undernutrition affects the foetal development, promoting renal alterations and adult hypertension. The present study investigates, in adult male rats, the effect of food restriction in utero on arterial blood pressure changes (AP), and its possible association with the number of nephrons, renal function and angiotensin II (AT1R/AT2R), glucocorticoid (GR) and mineralocorticoid (MCR) receptors expression. The daily food supply to pregnant rats was measured and one group (n=5) received normal quantity of food (NF) while the other group received 50% of that (FR50) (n=5). The AP was measured weekly. At 16 weeks of life, fractionator’s method was used to estimate glomeruli number in histological slices. The renal function was estimate by creatinine and lithium clearances. Blood and urine samples were collected to biochemical determination of creatinine, sodium, potassium and lithium. At 90th and 23rd days of life, kidneys were also processed to AT1R, AT2R, GR and MCR immunolocalization and for western blotting analysis. FR50 offspring shows a significant reduction in BW (FR50: 5.67 ± 0.16 vs. 6.84 ± 0.13g in NF, P<0.001) and increased AP from 6th to 12nd week (6thwk FR50: 149.1 ± 3.4 vs. 125.1 ± 3.2mmHg in NF, P<0.001and, 12ndwk FR50: 164.4 ± 4.9 vs. 144.0 ± 3.3 mmHg in NF, P=0.02). Expression of AT1R and AT2R were significantly decreased in FR50 (AT1, 59080 ± 2709 vs. 77000 ± 3591 in NF, P=0.05; AT2, 27500 ± 95.50 vs. 67870 ± 1509 in NF, P=0.001) while the expression of GR increased in FR50 (36090 ± 781.5 vs. 4446 ± 364.5 in NF, P=0.0007). The expression of MCR did not change significantly. We also verified a pronounced decrease in fractional urinary sodium excretion in FR50 offspring (0.03 ± 0.02 vs. 0.06 ± 0.04 in NF, p=0.03). This occurred despite unchanged creatinine clearance. The study led us to suggest that fetal undernutrition, with increased fetal exposure... (Complete abstract click electronic access below)

Aspectos reprodutivos e sociais e resistência óssea em ratos machos submetidos ao exercício físico e/ou a um anabolizante esteróide

Nowadays the regular practice of sports is known as a way to obtain a better quality of life. On the other hand, the media has been distorting this idea, determining the ideal body as the hypertrophy phenotype. It is well known that the genetic factor does not allow all individuals to have this body shape. Besides the fact that, the anxiety of these people in obtain quick results, as one of the globalization’s consequence, make use of anabolic steroid to achieve this goal. However the bodybuilding or the strength muscle gain, make anabolic steroids users abuse and in major cases the users do not know the side effects. In front of these considerations, the present study evaluated the effects of the treatment with anabolic steroids and/or high intensity physical training on the corporal developing, the reproductive organs, bone parameters (strength and bone deformation) and seminal parameters as well the social behavior (aggressiveness). In other to obtain the experimental group, male Wistar rats were used, with 75 days old. The groups were divided into: Vehicle Non-Training (NV), Anabolic Steroid-Non-Training (NA), Vehicle-Training (TV) and Anabolic Steroid-Training (TA). These rats received i.m. injections, twice a week, of anabolic steroid (5mg/kg per animal of nandrolona decanoate) or vehicle (the same volume of peanut oil per animal) and the group TV and TA were submitted to physical training three times per week, during eight weeks. The body mass, wet weight of reproductive organs, femur and semen of the different groups were measured. The aggressive test was also realized in two steps: the first, within 4 weeks of the treatment and the other step in the end of the treatment, in this period the animal was isolated. It was not observed alterations in body mass of the groups. Though it was observed a benefic effect on the maximum strength of the... (Complete abstract click electronic access below)

A influência do Relatório Beveridge nas origens do Welfare State Britânico (1942 – 1950)

This research analyzes the origin of Welfare State, from the Report by William Beveridge. At the end of Second World War, the concern about citizenship rescue spread the idea of Social Welfare State. The British influence, also represented by the Beveridge Report, is of great importance in this process. Thus, analyzing the Beveridge Plan, which proposed a set of reforms within the social security system, along with its contributions to the emergence of British Welfare State, is crucial to a more complete historical parameter on the subject of the Protector State. The goal of this study is to clarify the influence of the Beveridge Report in the practical organization of the Welfare system in England

Modelagem e simulação numérica de um sistema de refrigeração por absorção utilizando o par H2O-LiBr

The term refrigeration solar refers to any air conditioning system that uses solar energy as a primary energy source. The use of solar radiation for cooling purposes is divided according to their technological possibilities which are distinguished from one another as the way that energy is involved in the cycle, work or heat. The first case is related to vapor compression cycles, in which the work input is provided by the photovoltaic conversion of solar energy into electrical energy. In the second case, an absorption refrigeration cycle is used and the thermal energy collected from the solar radiation is provided at the generator of this cycle.. In this work a system with an absorption cycle using the pair BrLi-water, using solar energy as input is modeled. It is considered a simple refrigeration cycle whose the equations of mass and energy conservation in each component are developed in order to obtain an algebraic equation set and a simulation routine using the EES software. Although the simulation operates under certain specified thermal load it is possible to estimate the necessary areas of heat exchangers and solar collectors

Melhoria do planejamento para o fornecimento de materiais de modificações em aeronaves executivas

This paper presents a material demand forecasting to executive aircrafts modifications, the objective was to determinate a cadence of kits of materials in order reduce over stock, but also keeping the customer quality support. This work was motivated by the strong tendency that the market has to cut costs, especially those that do not add value to the product, waste. To solve the problem the Poisson probability distribution was used and also the error measures MPE, MAPE and MSE. At the end, after some adjustments, we found a satisfactory model for the problem

Geotecnologias para análise da expansão urbana e consequências na APP do Córrego Olinda - Rio Claro/SP

Despite the current Environmental Legislation resolution, concerning the protection of the Permanent Preservation Areas (PPA), be quite rigid, in practice, is observed noncompliance with the minimum limits of protection, especially in urban areas where, historically, the urbanization processes have been executed without compliance with the minimum standards of urban and environmental planning. Given the above, the present study aimed to analyze the urban sprawl evolution at the Olinda stream APP, located in the city of Rio Claro - SP. By means of the visual interpretation of aerial photographs in the GIS/ARCGIS environment, thematic maps of the urban sprawl of the years 1972, 1995 and 2010, as well as the Olinda Stream APP surroundings, were prepared. From the maps, it was possible to measure the occupation density for each scenario and indicate from which period the urbanization process has intensified. It was also possible to quantify the loss of vegetation area and indicate the major environmental problems in the basin of the Olinda stream. Therefore, the development of this research shows its importance, considering that its results can support the public administration, assisting in proper planning of land use and occupation in urban watersheds

O campo e a cidade em Presidente Prudente: uma contribuição aos estudos de clima urbano

O processo de urbanização é bastante expressivo na modificação do clima na escala local, pois as formas materiais assumidas pela cidade, bem como as atividades que nela se desenvolvem, provocam anomalias nos elementos do clima como a temperatura, umidade relativa do ar, direção e velocidade do vento. Destes, a temperatura tem se destacado nos estudos sobre o clima urbano, pois as características da área urbana promovem seu aumento tanto no ar quanto nos alvos da superfície. Nesse sentido, este estudo objetivou detectar as anomalias térmicas intraurbanas e suas magnitudes, relacionando-as com os tipos de uso e ocupação da superfície do solo no município de Presidente Prudente-SP. Para tanto, foram realizadas análises das diferenças térmicas e higrométricas entre o urbano e o rural em dias representativos do inverno e do verão, e a verificação da temperatura da superfície através do sensoriamento remoto no infravermelho termal. Os resultados apresentaram que os tipos de tempo, assim como as características da superfície foram responsáveis pelas maiores ou menores diferenças entre a área urbana e a rural, o que demonstra a importância de se adequar o planejamento urbano às características do ambiente local

Modulação da expressão de moléculas de superfície em macrófagos tratados com compostos isolados de microrganismos marinhos

Atualmente são conhecidas aproximadamente 10.000 substâncias do metabolismo secundário de invertebrados e microorganismos marinhos. Dentre os organismos marinhos estudados do ponto de vista químico e farmacológico, destacam-se, as esponjas, as ascídias, os briozoários e os octocorais. No entanto, pouco se sabe quanto ao potencial imunomodulador de compostos isolados de microrganismos marinhos, em especial daqueles isolados da costa brasileira. A propriedade anti-inflamatória de diferentes extratos brutos foi inicialmente avaliada pelo potencial destes compostos quanto à inibição da produção de óxido nítrico (NO) em linhagem de macrófagos, RAW 264.7. Posteriormente as amostras que se mostraram promissoras foram também avaliadas em relação ao potencial imunomodulador quanto a expressão de moléculas de superfície relacionadas migração (Mac-1 ou CD11b) e ativação celular (CD80 e CD86) em linhagens de macrófagos estimulados com LPS. Nossos resultados mostram que dentre as 289 amostras testadas apenas o extrato DLM33 e as substâncias Ma(M3%)J-MeOH e Dr(M3%)6-MeOH/H2O foram inicialmente considerados promissores quanto capacidade de inibir a síntese de NO por macrófagos. O extrato DLM33 foi capaz de de modular apenas a porcentagem de macrófagos positivos para CD80 na presença de LPS. No entanto, a substância Dr(M3%)6-MeOH/H2O não se mostrou eficiente quanto a modulação da expressão de moléculas de superfície Mac-1, CD80 e CD86. Surpreendentemente, a substância Ma(M3%)J-MeOH apresentou um potencial imunoestimulador quanto a expressão de Mac-1+/CD80+, mas não de CD86, em macrófagos sugerindo um possível efeito adjuvante desta substância. O efeito imunoestimulador da substância Ma(M3%)J-MeOH será futuramente investigado utilizando diferentes abordagens in vitro e in vivo para validar os resultados obtidos... (Resumo completo, clicar acesso eletrônico abaixo)

Ginástica rítmica e especialização precoce: caminhos das pesquisas e publicações no Brasil

This final course project originates itself from the discussions of the Group of Studies and Pedagogical Research in Gymnastics (GEPPEGIN) of Unesp/RC and starts with the Pedagogy of Sport, with the purpose of knowing, analysing and discussing its existence and paths, in a series of discussions about the early specialization. The early specialization is a theme that relates frequently to the modalities of gymnastics, the focus point being that most gymnasts are specialized younger than most athletes from other sports (SCHIAVON, 2009), and not always in a proper way. It is from this issue that the intention of this study begins: knowing, analysing and discussing the existence and the ways of discussions about early specialization in researches and publications related to Rhythmic Gymnastics in the last decade (2002-2012) in Brazil. For the development of this qualitative research of scientific initiation a bibliographic research will be conducted about Rhythmic Gymnastics, with the focus on arising researches from post graduation programs stricto-sensu, recognized by Capes and, scientific papers, published during indexed periods in Brazil and classified in Qualis of Physic Education

Conduta do paciente hipertenso frente ao tratamento clínico

The urbanization process established in Brazilian society since the middle of last century brought changes in the population habits and customs, which was responsible for the increased of chronic diseases incidence, such as arterial hypertension, for example. Although this is a common disease nowadays, it is still difficult to establish a significant control in subjects with this disease and its consequences. This is apparently due to lack of interest to the correct plan of care developed for the treatment of this disease. The nursing consultation identifies potential problematic situations and the patient needs, setting actions that are complementary to their benefit in order to promote health. The present work aims to observe how the nursing consultation is being used as strategy for patients with arterial hypertension, and to understand the difficulties faced during treatment of these patients. For this purpose, it was performed qualitative and quantitative studies with patients from Centro Saúde Escola (CSE), Unidade Auxiliar, Faculdade de Medicina de Botucatu, UNESP, located in Botucatu, employing as methodology the Discourse of the Collective Subject and descriptive statistical analysis of quantitative results. The vast majority of consultations were held by medical professionals and it was observed that the multidisciplinary work still needs to be recognized and valued by users. The lack of knowledge of some individuals in relation to the potential and importance of the nursing consultation occurs not only for the treatment of arterial hypertension, but for the treatment and monitoring of the individual as a whole. Therefore, it is still necessary to clarify the true essence and necessity of the nursing consultation, since so important tool should be used in its entirely. Moreover, the role of the multidisciplinary team should be more discussed

Pré-sal e o novo marco regulatório: um estudo sobre o fundo social

This work intends to discuss about the current happenings in oil sector, and how the recent discovery of huge oil reserves on the layer known as Pre-Sal can positively transform in the socioeconomic context, the country. The impact of this huge quantity of natural resources it depends on the legislative policies adopted for the exploration and production (E & P) in the Pre-Salt layer, and the way in which laws are imposed for distribution of such resources. Therefore, it is made a shortly background of the laws from oil exploration, production and distribution, since the monopoly of Petrobras, to nowadays. To this end, an analysis is performed about the Oil Law, and about the possible legislative changes with the new Regulatory Framework. This monograph attempts to prove, based on historical data, socioeconomic facts, and international experiences, using either comparative statistical, that with the discovery in the Pre-Salt area, the best way to optimize the use of these resources, mainly the reduction of social inequality and economic contrasts, a legacy from colonization, would directly those recipes to a National Development Fund, the Social Fund, established by law for the new Regulatory Framework

Pós-processamento de formas de ondas oriundas de descargas atmosféricas no Centro de Estudos de Descargas Atmosféricas e Alta Tensão (CENDAT) – IEE/USP

Atmospheric Discharges are responsible for several lost in the electrical system therefore it´s done studies to find ways to reduce the problem caused by discharges. This branch of engineering is necessary the gathering, stock and analysis of large quantity of data to validate or refuse the many studies produced about it The CENDAT proposed a project to collect data on induced voltages in distribution lines and current waveform of the lightning, but a difficulty that arose was the accumulation of data due to lack of manpower available to catalog all the data collected. Thinking in this difficulty, the engineer Acacio Silva Neto CENDAT´s researcher with trainees began to develop a program to solve this problem. This work keeps the development of this program in order to solve the problem of accumulation of data

Caracterização petrográfica e geoquímica das rochas encaixantes da mineralização de ouro do alvo lavra velha - Ibitiara (BA)

The Lavra Velha gold prospect is located in Ibitiara city, in the Espinhaço Setentrional physiographic domain, on the west edge of Chapada Diamantina – central part of Bahia. It is inserting on Gavião Block, a compartment of São Francisco Cráton (Almeida, 1977). The Lavra Velha gold dump is formed by an association of hydrothermal breccia lodged in acid and intermediate rocks, classifying in tonalite, granodiorite and diorite, with high alteration, cut off by a vein and venules system constituted by hydrothermal association composed by hematite, tourmaline, quarz and sericite, located in the north limit of Ibitiara granite. In the regional geological context the area is represented by Archaean rocks (Paramirim Complex) and Paleoproterozoic rocks (Ibitiara granitoid and Matinos Granite) constituted the basement, following by paleo to mesozoic pluton-vulcanic-sedimentary association of Rio dos Remédios Group, intruded by mafic rocks. It was used geochemistry and petrographic analysis compiling to field works data to characterize the rocks where the gold mineralization is inserting. Previously these rocks were classifying in volcanic rocks of Novo Horizonte Formation. Developing this monograph’s work the petrogenetic characteristics suggesting that these rocks called volcanic actually belong to Ibitiara granitoid as a portion more metamorphosed. The green schist is the predominant metamorphism in the area with low deformation, associated to high concentration of fluid circulating. The hydrothermal alteration is the process responsible for rocks modifications and strong sericitization generalize

Influência do uso e ocupação da terra na dinâmica do rio São Lourenço - estado de Mato Grosso

This study aims to analyze the relationship between deforestation in the highlands of the São Francisco River Basin over the past 45 years due to agricultural activities and livestock , and the observed changes in the dynamics of the same river in the Pantanal of Mato Grosso , as sinuosity , discharge sediment , flow, points of erosion and morphological changes . It is observed that deforestation occurs in the plain and on the plateau , however with much more intensity in the latter, provided the extensive land use in the region . Thus, the study aims to contribute to a better understanding of the relationships between the uplands and flood plains . To achieve this goal will be used proper methods of geomorphological and geological sciences , with emphasis on the use of satellite imagery and hydrological data side . The research will include the following steps : I) literature review ; II) characterization geomorphological , geological , hydrological and climate , III) Dynamics of vegetation ; IV) Analysis of cause-effect relationships in the river system . Product analysis will suggest preventive measures to minimize the effects caused by the practices of use and occupation in the study area, as well as other regions suffer the same impacts

Análise comparativa de escores em cobranças de pênalti entre situações de final de jogo e as demais situações no futebol de campo: colaborações da psicologia do esporte

O estresse psicológico é um importante fator que ocasiona uma queda no desempenho de atletas, independente do esporte. No Brasil o de maior visibilidade e mais assistido e comentado pela mídia é o futebol. Tendo em vista isso a pratica dessa modalidade em alto nível pode gerar certo estresse, no entanto a situações específicas durante o jogo que podem aumenta-lo ainda mais, dentre elas temos o pênalti considerado a melhor oportunidade de marcar o gol e a mais fácil, exatamente por isso essa situação não admite falhas. Apesar de já ser uma situação que causa alto nível de ansiedade, existem alguns fatores que podem influenciar mais ainda negativamente o cobrador, portando o presente estudo tem como objetivo primeiramente de encontrar o fator que causa maior influencia negativa nos atletas e posteriormente comparar com as cobranças de pênalti do Campeonato Brasileiro de Futebol de 2010 (CBF) nessa situação com as demais. Os dados obtidos a partir da aplicação de um inventário demostraram que o fator que mais influencia negativamente jogadores de futebol durante cobranças de pênalti são situações de final de jogo, assim o objetivo do presente estudo é de comparar as cobranças de pênaltis do Campeonato Brasileiro de Futebol de 2010, em situações de final de jogo com as demais. Os resultados obtidos mostraram uma queda de 4% nos escores em situações de final de jogo comparados com as demais