Avaliação da resistência em caprinos a ninfas do carrapato Amblyomma cajennense (Fabricius, 1787) e da reatividade cruzada com A. hebraeum (Koch, 1844) (Acari:Ixodidae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Componente celular inflamatório no local da fixação de carrapatos adultos Rhipicephalus sanguineus LATREILLE, 1806 em cães imunizados com o antígeno Bm86

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

As relações EUA-América Latina: medidas e consequencias da polìtica externa norte-americana para combater a produção e o tráfico de drogas ilícitas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Resposta imune induzida pelas peçonhas do bagre Cathorops agassizii

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Marcação de Diatraea saccharalis (Fabr.) (Lepidoptera: Crambidae) e dispersão de Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Resposta imune celular e humoral em aves (Gallus gallus) vacinadas, antes e após o desafio com Salmonella enteritidis

Pós-graduação em Medicina Veterinária - FCAV

Second life®: corpo ou avatar? realidade ou fantasia?

Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC

Análise temporal da composição, abundância, diversidade dos Cladocera e crescimento alométrico da Daphnia spp. O. F. Müeller, 1785 na Lagoa do Camargo, lateral ao Rio Paranapanena em sua zona de desembocadura na Represa do Jurumirim

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Inclusion complex of S(-) bupivacaine and 2-hydroxypropyl-β-cyclodextrin: study of morphology and cytotoxicity

Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-) bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheral and central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD). Differential scanning calorimetry, scanning electron microscopy and X-Ray diffraction analysis showed structural changes in the complex. In preliminary toxicity studies, the cell viability tests revealed that the inclusion complex decreased the toxic effect (p<0.001) produced by S(-) bvc. These results suggest that the S(-) bvc:HP-ß-CD inclusion complex represents a promising agent for the treatment of regional pain. Keywords: S(-) bupivacaine; cyclodextrin; inclusion complex.

A Reproducible Venous Thrombosis Model in Horses Induced by the Combination of an Endothelial Lesion and Blood Flow Stasis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Changes in the synganglion of Rhipicephalus sanguineus (Latreille,. 1806) (Acari: Ixodidae) female ticks exposed to permethrin: An ultrastructural overview

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A(2)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação espaço-temporal da distribuição de fósforo na água e nos sedimentos de fundo das sub-bacias dos rios Cuiabá e São Lourenço e em algumas baias do Pantanal Matogrossense

Pós-graduação em Química - IQ

Angiotensin II AT(1) receptor mutants expressed in CHO cells caused morphological change and inhibition of cell growth

To assess the importance of the leucine residues in positions 262 and 265 of the angiotensin AT, receptor for signaling pathways and receptor expression and regulation, we compared the properties of CHO cells transfected with the wild type or the L262D or L265D receptor point mutants. It was found that the two mutants significantly increased the basal intracellular cyclic AMP (cAMP) formation in an agonist-independent mode. The morphology transformation of CHO cells was correlated with the increased cAMP formation, since forskolin, a direct activator of adenylate cyclase mimicked this effect on WT-expressing CHO cells. DNA synthesis was found to be inhibited in these cell lines, indicating that cAMP may also have determined the inhibitory effect on cell growth, in addition to the cell transformation from a tumorigenic to a non-tumorigenic phenotype. However a role for an increased Ca2(+) influx induced by the mutants in non-stimulated cells cannot be ruled out since this ion also was shown to cause transformed cells to regain the morphology and growth regulation. (c) 2005 Elsevier B.V. All rights reserved.

Imunidade de aves (Gallus gallus) para Salmonella enterica subesp. enterica Sorovar Gallinarum biovar Gallinarum

Pós-graduação em Medicina Veterinária - FCAV