Resposta tecidual de dentes reimplantados utilizando plasma pobre em plaquetas, plasma rico em plaquetas e células-tronco da medula óssea: estudo em cães

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Vitamina E no plasma de recém-nascidos de pré-termo de muito baixo peso no primeiro mês de vida. Relação com a vitamina E recebida

Pós-graduação em Pediatria - FMB

Avaliação do reparo ósseo de defeitos de tamanho crítico tratados com plasma rico em plaquetas ou com fibrina rica em plaquetas: estudo histomorfométrico e imunoistoquímico em calvárias de ratos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeito da córtico-terapia e plasma seminal na resposta inflamatória e fertilidade de éguas submetidas à inseminação arterial

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Plasma rico em plaquetas empregado na cirurgia reconstrutiva em coelhos (Oryctolagus cuniculus): avaliação da exequibilidade da técnica, achados macroscópicos e histopatológicos

Pós-graduação em Cirurgia Veterinária - FCAV

Cell adhesion and growth on surfaces modified by plasma and ion implantation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fibrinogen-Induced Streptococcus mutans Biofilm Formation and Adherence to Endothelial Cells

Streptococcus mutans, the predominant bacterial species associated with dental caries, can enter the bloodstream and cause infective endocarditis. The aim of this study was to investigate S. mutans biofilm formation and adherence to endothelial cells induced by human fibrinogen. The putative mechanism by which biofilm formation is induced as well as the impact of fibrinogen on S. mutans resistance to penicillin was also evaluated. Bovine plasma dose dependently induced biofilm formation by S. mutans. Of the various plasma proteins tested, only fibrinogen promoted the formation of biofilm in a dose-dependent manner. Scanning electron microscopy observations revealed the presence of complex aggregates of bacterial cells firmly attached to the polystyrene support. S. mutans in biofilms induced by the presence of fibrinogen was markedly resistant to the bactericidal effect of penicillin. Fibrinogen also significantly increased the adherence of S. mutans to endothelial cells. Neither S. mutans cells nor culture supernatants converted fibrinogen into fibrin. However, fibrinogen is specifically bound to the cell surface of S. mutans and may act as a bridging molecule to mediate biofilm formation. In conclusion, our study identified a new mechanism promoting S. mutans biofilm formation and adherence to endothelial cells which may contribute to infective endocarditis.

Side Effects of Neem Oil on the Midgut Endocrine Cells of the Green Lacewing Ceraeochrysa claveri (Navas) (Neuroptera: Chrysopidae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Testosterone Therapy Differently Regulates the Anti- and Pro-Inflammatory Cytokines in the Plasma and Prostate of Rats Submitted to Chronic Ethanol Consumption (UChB)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Cell Adhesion to Plasma-Coated PVC

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions

Type 2 diabetes and obesity are increasing worldwide and linked to periodontitis, a chronic disease which is characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium. The mechanisms underlying the association of diabetes mellitus and obesity with periodontal destruction and compromised periodontal healing are not well understood, but decreased plasma levels of adiponectin, as found in diabetic and obese individuals, might be a critical mechanistic link. The aim of this in vitro study was to examine the effects of adiponectin on periodontal ligament (PDL) cells under normal and regenerative conditions, and to study the regulation of adiponectin and its receptors in these cells. Adiponectin stimulated significantly the expression of growth factors and extracellular matrix, proliferation, and in vitro wound healing, reduced significantly the constitutive tumor necrosis factor-alpha expression, and caused a significant upregulation of its own expression. The beneficial actions of enamel matrix derivative on a number of PDL cell functions critical for periodontal regeneration were partially enhanced by adiponectin. The periodontopathogen Porphyromonas gingivalis inhibited the adiponectin expression and stimulated the expression of its receptors. In conclusion, reduced levels of adiponectin, as found in type 2 diabetes and obesity, may compromise periodontal health and healing.

Platelet-Rich Plasma Derived From Bone Marrow Aspirate Promotes New Cementum Formation

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Expressão de matriz metaloproteinases e PCNA me úlceras corneais profundas, induzidas em coelhos, tratadas com plasma rico em plaquetas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)