69 resultados para modesto


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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The Information Access law, sanctioned in November 18, 2011, regulates the constitutional right of access to public information by Brazilian citizens. Although this law requires the provision of information of public interest, it does not define how such information should be made available. Ideally, information should be in an open format, allowing its use in an efficient and fast way. In the official sites of the federal government the way information is currently available does not allow its reuse as they are presented in dynamic pages from the selection parameters and filters. The objective aim of this paper is to present the system called MDDIR Tool, which proposes ways to persist, represent and retrieve digital information resources generated by the Federal Government official sites. Although this system had been designed for a specific purpose, it may be applied to other fields with similar characteristics. The purpose is to facilitate the access to open data, allowing such data to be consolidated and organized , generating new knowledge and information easy to be interpreted by the general population.

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Ivabradine (IVB) is a heart rate lowering agent that acts via selective inhibition of the pacemaker funny current in sinoatrial nodal P cells, thus, reducing heart rate at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. IVB exerts no effect on external respiratory function parameters and it may also play a role in patients with concurrent chronic obstructive pulmonary disease. This property constitutes an important advantage over β-blockers. IVB acts by reducing the heart rate in a mechanism different from β-blockers, calcium channel blockers or late sodium channel blockers, three commonly prescribed antianginal drugs. As clinical trials have shown, it is remarkably well-tolerated and offers an alternative for patients who cannot take β-blockers. The combination of IVB and atenolol at commonly used doses in patients with chronic stable angina produced additional efficacy with no untoward effect on safety or tolerability. Additionally, side effects are rare and largely limited to a luminous phenomenon or phosphenes. This sensation is thought to be due to a block of Ih in the retina, a current very similar to cardiac If channels. IVB is contraindicated in patients with sick sinus syndrome or sinus node dysfunction and in patients taking hepatic inhibitors of Cytochrome P450 family 3, subfamily A, polypeptide 4 (abbreviated CYP3A4), with exception of omeprazole or lansoprazole. This review briefly summarizes the main studies regarding this drug.

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Background: Rheumatic diseases in children are associated with significant morbidity and poor health-related quality of life (HRQOL). There is no health-related quality of life (HRQOL) scale available specifically for children with less common rheumatic diseases. These diseases share several features with systemic lupus erythematosus (SLE) such as their chronic episodic nature, multi-systemic involvement, and the need for immunosuppressive medications. HRQOL scale developed for pediatric SLE will likely be applicable to children with systemic inflammatory diseases.Findings: We adapted Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY (c)) to Simple Measure of Impact of Illness in Youngsters (SMILY (c)-Illness) and had it reviewed by pediatric rheumatologists for its appropriateness and cultural suitability. We tested SMILY (c)-Illness in patients with inflammatory rheumatic diseases and then translated it into 28 languages. Nineteen children (79% female, n= 15) and 17 parents participated. The mean age was 12 +/- 4 years, with median disease duration of 21 months (1-172 months). We translated SMILY (c)-Illness into the following 28 languages: Danish, Dutch, French (France), English (UK), German (Germany), German (Austria), German (Switzerland), Hebrew, Italian, Portuguese (Brazil), Slovene, Spanish (USA and Puerto Rico), Spanish (Spain), Spanish (Argentina), Spanish (Mexico), Spanish (Venezuela), Turkish, Afrikaans, Arabic (Saudi Arabia), Arabic (Egypt), Czech, Greek, Hindi, Hungarian, Japanese, Romanian, Serbian and Xhosa.Conclusion: SMILY (c)-Illness is a brief, easy to administer and score HRQOL scale for children with systemic rheumatic diseases. It is suitable for use across different age groups and literacy levels. SMILY (c)-Illness with its available translations may be used as useful adjuncts to clinical practice and research.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em História - FCLAS

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This study aimed to gather the determinants and indicators of environmental innovations through a literature review on the topic. But before it was made a presentation of concepts and typology of eco-innovation, with different points of view. The determinant more found by most authors was regulation, followed by market factors, cost reductions and company image. To highlight these determinants were presented some cases studies, including evidence in Brazil. Due to the short bibliography and case studies, there are few indicators of environmental innovation found, highlighting the investment in environmental R&D and patents

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A decisive moment of the diffusion of symbolism in Brazil was the year 1893, when were published Missal e Broquéis, first Cruz e Sousa’s symbolist works. It is important to consider the context in that those books appear and the repercussion that they provoked, because this investigation can perhaps helps to understand the reason by which the symbolism had achieved a relatively modest development in Brazil.

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Pós-graduação em Agronomia (Produção Vegetal) - FCAV

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The enriched environment (EE) is a promoter of physical activity, by its characteristics such as ample room for movement and exploration, presence of wheels, tunnels and toys. The maintenance of animals in enriched environment can bring a range of benefits, but the majority of the researches investigate cognitive parameters and changes related to the nervous system. The aim of this study was to examine the effects of the maintenance of aged rats in enriched cages on biochemical and metric parameters. Wistar rats were randomly distributed (n=6) into two groups during 6 weeks: control (C) in a conventional cage and enriched environment (EE). The body mass were recorded weekly and the body length at the end of the study. After euthanasia, blood was collected for analysis of glucose, triglycerides and the brain was collected for analysis of mass. The EE group had higher brain mass and lower gain of body weight compared to control group. The control group animals had normal values of blood glucose and triglyceride levels, and the maintenance in an EE did not promote changes in these parameters. Therefore, it can be concluded that the EE group increases brain mass and reduces the gain of body weight without changing the blood glucose and triglycerides in aged animals.

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The tangerine 'Sunki' are highly relevant for the Brazilian citrus industry by presenting important traits for genetic improvement and to be considered a great portaenxento. In this context, the objective of the present work to study the characterization of the fruits of citrus rootstock 'Sunki', depending on the position on the plan and also the germination of their seeds. The physical characteristics evaluated were fruit weight, longitudinal and equatorial diameters of the fruit longitudinal diameter / equatorial diameter, number of buds per fruit, weight of buds and bark and number of viable seeds per fruit. As for the chemical characterization was evaluated titratable, acidity, soluble solid, "Ratio", pH and vitamin C. For the evaluation of these variables, the fruits were obtained from the northeast, southwest, northwest and southeast quadrants. Regarding the evaluation of seed germination, different doses of gibberellic acid and Stimulate were used. The seeds extracted from ripe fruit, washed, dried in the shade and stored in BOD. Immediately after, they were treated for 24 hours with plant growth regulators. After soaking, the seeds were placed in a germinator in germitest paper. After initiation of the germination process, the evaluations were performed daily until the thirty- fourth day. Fruits of 'Sunki'mandarin with uneven as the fruit position within the canopy, the use of gibberellic acid and growth promoter is promising for commercial use on seed germination of this rootstock.

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The nutrition of the orchards is the major factor of productivity, being necessary to know the proper doses of fertilizers and their influence on fruit quality attributes for industrialization. This study evaluated the effects of different doses of nitrogen and potassium on the productivity of guava trees and also on the values of pH, soluble solids (SS), titratable acidity (TA) and pulp/kernel ratio of guavas. The experiment was conducted at Vista Alegre do Alto, SP in an irrigated 'Paluma'guava orchard, 7 years old, managed with pruning during three consecutive cycles of production. The soil of the area was dystrophic Ultisol. The experimental design was the randomized blocks, in factorial, with four nitrogen doses (0, 0.5, 1 and 2 kg of N plant(-1)) and four of potassium (0, 0.55, 1.1 and 2.2 kg of K2O plant(-1)), with three replications. Nitrogen fertilization increased productivity and the pH of the fruit, being explained by the quadratic polynomial regression models; reduced linearly the pulp/kernel ratio and do not influenced the SS and TA values. On the other hand, potassium fertilization and N x K interaction had no significant effects on productivity and the other characteristics evaluated.