Biomarcadores de progressão em carcinomas orais

Pós-graduação em Ciências Biológicas (Genética) - IBB

Análise integrada aplicada à exploração de água subterrânea na Bacia do Rio Jundiaí (SP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Enfrentamento do problema das divergências de tradução por um sistema de tradução automática: um exercício exploratório

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Imagem turística de Itanhém, litoral sul paulista

Pós-graduação em Geografia - IGCE

COBERTURAS SEDIMENTARES CENOZÓICAS DA BACIA DO RIO JUNDIAÍ – SP.

Este trabalho apresenta a caracterização geológica das coberturas sedimentares cenozóicas da bacia do Rio Jundiaí e suas relações com a evolução geológica regional. Sobre o Embasamento Cristalino, ocorrem depósitos paleozóicos pertencentes ao Grupo Itararé, depósitos terciários e quaternários. Os depósitos terciários constituem ocorrências locais, pois grande parte das seqüências foi removida pela erosão e os restos estão quase sempre encobertos pelas coberturas mais jovens. Correspondem a um antigo sistema de leques aluviais com área-fonte na Serra do Japi e sua origem se associa à formação das escarpas de falhas que controlam as áreas serranas. Os depósitos colúvio-eluviais são constituídos por material areno-argiloso maciço com linhas de pedra basais, que compõe corpos descontínuos controlados por estruturas geológicas. Os depósitos aluviais também acompanham importantes direções estruturais. A distribuição destas coberturas é condicionada pelo relevo, onde conjuntos de falhas de direção predominantemente NW-SE promoveram o abatimento da porção central da área, controlando a implantação da bacia hidrográfica do Rio Jundiaí. A ocorrência de depósitos aluviais em locais onde atuam esforços transtensivos é de grande importância para a exploração dos recursos hídricos subterrâneos. O afeiçoamento da paisagem condicionado por fatores endógenos atesta a importância dos processos neotectônicos em ambiente intraplaca.

Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression

Pós-graduação em Ciências Biológicas (Genética) - IBB

Atividade alelopática de Copaifera langsdorffii DESF: abordagem fitoquímica e molecular

Pós-graduação em Ciências Biológicas (Botânica) - IBB

Correlação entre uso da terra e qualidade da água subterrânea

Este trabalho descreve a correlação entre parâmetros de uso da terra (área agricultada, área edificada, pastagem, solo exposto e vegetação intermediária) e de qualidade da água subterrânea (pH, sólidos totais dissolvidos - STD, K+, Na+, Fe+3, Ca+2, Mg+2, NO2 -, NO3 -, P total e coliformes), no sul do estado do Espírito Santo. A delimitação da área de influência de poços e a identificação das classes de uso da terra foram feitas utilizando-se Sistema de Informações Geográficas. Por meio da análise de correlação canônica, foi possível estimar dois índices: índice de uso da terra e índice de qualidade da água, ambos padronizados. A correlação canônica foi significativa entre o primeiro par de variáveis canônicas, indicando relação linear entre os grupos. Desta forma, é possível afirmar que o uso da terra influenciou a qualidade da água subterrânea, principalmente pelo incremento da concentração de alguns elementos químicos.

Interação entre o gene TKN2 (KNOX-type I) e o miR156 node durante a transição de fase vegetativa para reprodutiva em tomateiro (Solanum lycopersicum)

Pós-graduação em Ciências Biológicas (Genética) - IBB

Involvement of Renal Corpuscle microRNA Expression on Epithelial-to-Mesenchymal Transition in Maternal Low Protein Diet in Adult Programmed Rats

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

MicroRNA Signature Obtained From the Comparison of Aggressive With Indolent Non-Hodgkin Lymphomas: Potential Prognostic Value in Mantle-Cell Lymphoma

Purpose Mantle-cell lymphoma (MCL) has a variable natural history but is incurable with current therapies. MicroRNAs (miRs) are useful in prognostic assessment of cancer. We determined an miR signature defining aggressiveness in B-cell non-Hodgkin lymphomas (NHL) and assessed whether this signature aids in MCL prognosis.MethodsWe assessed miR expression in a training set of 43 NHL cases. The miR signature was validated in 44 additional cases and examined on a training set of 119 MCL cases from four institutions in Canada. miRs significantly associated with overall survival were examined in an independent cohort of 114 MCL cases to determine association with patient outcome. miR expression was combined with current clinical prognostic factors to develop an enhanced prognostic model in patients with MCL.ResultsFourteen miRs were differentially expressed between aggressive and indolent NHL; 11 of 14 were validated in an independent set of NHL (excluding MCL). miR-127-3p and miR-615-3p were significantly associated with overall survival in the MCL training set. Their expression was validated in an independent MCL patient set. In comparison with Ki-67, expression of these miRs was more significantly associated with overall survival among patients with MCL. miR-127-3p was combined with Ki-67 to create a new prognostic model for MCL. A similar model was created with miR-615-3p and Mantle Cell Lymphoma International Prognostic Index scores.ConclusionEleven miRs are differentially expressed between aggressive and indolent NHL. Two novel miRs were associated with overall survival in MCL and were combined with clinical prognostic models to generate novel prognostic data for patients with MCL. (C) 2013 by American Society of Clinical Oncology

In Vitro Regulation of CCL3 and CXCL12 by Bacterial By-products Is Dependent on Site of Origin of Human Oral Fibroblasts

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

High protein microparticles produced by ionic gelation containing Lactobacillus acidophilus for feeding pacu larvae

Microparticles with high protein content can be used as diets to mimic the proximate composition of Artemia nauplii. After production, the particles were characterized with respect to their proximate composition, mean size, morphology, and rehydration behavior after drying. The protein content, lipid content and the particle moisture were similar to Artemia nauplii, with mean values of 50, 23, and 85%, respectively. Additionally, the particles were used in a pacu (Piaractus mesopotamicus) larval growth experiment. Also, the probiotic Lactobacillus acidophilus was added to one of the diets, and the effects of the diets were evaluated on larvae growth and stress resistance. Larvae fed the experimental diets had lower growth than larvae fed with Artemia nauplii or a commercial diet. All of the evaluated diets, including the experimental ones, showed high ingestion rates (>90%). In the stress test by air exposure, larvae fed with the microparticle without probiotic exhibited a significantly higher mortality than those fed the commercial diet or those fed with Artemia nauplii. The low growth rates may have been due to a potential nutritional inadequacy with respect to the low mineral/vitamin content of the experimental diets. (C) 2014 Elsevier Ltd. All rights reserved.

Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise da expressão gênica de pequenos RNAs derivados de tRNAs (tRFs) em plantas

Small non coding RNAs emerged as important characters in several biology aspects. Among then, the most studied are microRNAs (miRNAs) and short interfering RNAs (siRNAs), that regulate their target gene post-transcriptionally in plants, animals and RNAi pathway intermediates, respectively. Both of classes have similar biogenesis being processed by Dicer enzymes and subsequent association with Argonaute enzymes. In plants, miRNAs and siRNAs have important functions in development, genome integrity and biotic and abiotic stress responses. The advances in high-throughtput sequencing and in silico analisys provide the uncover of new small non coding RNAs classes, many of them with unknown functions and biogenesis. tRNA derived small RNAs (tRFs) are a small non coding RNA class, that have as precursor a tRNA molecule. These were uncovers in the last decade in many organisms and, recently, in plants. Recent works detected tRFs from different sizes, with different source portions of the mature tRNA molecule (5’ end; 3’ end, anti-codon loop) and some from the tRNA precursor (pre-tRNA), suggesting that may be a novel class of small RNA and not random degradation products. Works in humans showed that some tRFs are processed by the Dicer enzymes, have association with the Argonaute enzymes and cell differentiation, tumor appearance and gene silencing related functions. Works in Arabidopsis and pumpkin (Cucurbita maxima) showed, respectively, that the tRFs have nutritional stress response possible functions and long distance signaling function between source and drain tissues, and may affect the translation. The tRFs biogenesis in plants are, until now an unknown, absence information about it in the literature and its possible biological functions are few studied yet, making then interesting target for studies among the small non coding RNAs in plants