Pediatric Chronic Sclerosing Sialadenitis: Kuttner Tumor

Chronic sclerosing sialadenitis is an uncommon cause of salivary gland enlargement mainly occurring in the fifth and seventh decade of life. In the Western population, chronic sclerosing sialadenitis has been characterized as an IgG4-related disease. Although rare, this lesion occurs in children. To increase awareness about this entity in the pediatric age group, we report the case of an 11-year-old boy with a hard, 4.0-cm circumscribed mass in the right submandibular gland. Histologically there was marked distortion of the gland architecture by a dense lymphocytic infiltrate and extensive fibrosis with septa that crossed and distorted the gland, leaving atrophic acini and dilated, irregular ducts. The lymphoid infiltrate formed multiple follicles with active germinal centers, numerous plasma cells, and areas with diffuse arrangement. Immunophenotyping showed abundant CD20- and CD3-positive lymphocytes; cytokeratin AE1/AE3 highlighted the distorted architectural pattern; IgG staining showed large numbers of positive cells infiltrating the interstitium and surrounding the atrophic acini and ducts. IgG4 staining revealed a large proportion of positive infiltrating elements. Kuttner tumor belongs to the group of IgG4-related sclerosing diseases. The differential diagnosis includes pleomorphic adenoma and other salivary gland neoplasms. Its recognition in children is important clinically because this entity is amenable to steroid treatment, and additional work up and follow up is warranted to stave off other IgG4-related diseases/complications.

Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom

Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 Å resolution and the anion-binding site has been characterized. © 2006 International Union of Crystallography. All rights reserved.

Software educacional sobre escala de pessoal de enfermagem: Elaboração, desenvolvimento e aplicação via internet

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Mnitoramento do desenvolvimento infantil realizado no Brasil

Objective: To review scientific literature in order to check how infant development surveillance is being carried out in Brazil. Data sources: Search on databases (PubMed, Medline, SciELO and CAPES Database Thesis) for studies on medical practices related to surveillance and monitoring of child development in Brazil from 2000 to 2011. The terms used for research were: child development surveillance, early intervention, developmental screening, and developmental screening tests. There were ten texts on the subject under study. Original articles, reviews, and thesis were analyzed, as well as the reference lists of publications on the topic. Data synthesis: Studies on monitoring of child development in Brazil showed major failures from pediatrician formation to clinical practice. Conclusions: It is urgent to offer continued medical education to pediatricians in order to update their knowledge about child development monitoring, especially due to the increasing numbers of preterm infants.

Tàpies e seus corpos: um olhar sexuado

Pós-graduação em Artes - IA

Caracterização sistêmica de alterações em redes fisiológicas de plantas C3 e C4 submetidas à deficiência hídrica

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A proteção dos direitos autorais a partir da realidade Internet: a perspectiva brasileira

Pós-graduação em Ciência da Informação - FFC

Acúmulo de saberes e experiência formativa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Habilidades funcionais de alunos com deficiência matriculados no ensino infantil: avaliação de professores

Pós-graduação em Educação - FFC

O papel do fator de crescimento semelhante à insulina-l sobre os efeitos deletérios do choque térmico em oócitos bovinos no estádio de vesícula germinativa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Governar é povoar: a influência alberdiana na organização do Estado argentino nos meados do século XIX

Pós-graduação em História - FCHS

Rádio, modernidade e sociedade em Ribeirão Preto, 1924-1937

Pós-graduação em História - FCHS

O Paraguai de Roa Bastos: história e crítica social

Pós-graduação em História - FCLAS

A contradição entre herança ibérica e modernização brasileira no pensamento político de Sérgio Buarque de Holanda: o livro Raízes do Brasil

Pós-graduação em História - FCLAS

A relação do idoso com o aprendizado musical

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)