Estudo clínico e laboratorial da intoxicação experimental por amitraz em gatos e comparação entre ioimbina e atipamezole como tratamento

Pós-graduação em Medicina Veterinária - FMVZ

Comparação da espirometria, da qualidade de vida e da capacidade funcional de exercício em pacientes com doença arterial coronariana estável de acordo com a história tabágica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O monitoramento dos movimentos corporais do sono e do ritmo de sono-vigília como indicador das alterações provocadas pela asfixia em ratos recém-nascidos

Pós-graduação em Pediatria - FMB

Avalição do desfecho clínico da febre reumática durante duas décadas no Hospital das Clínicas de Botucatu

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Administração subaracnóide de anestésicos locais em coelhos anestesiados com isofluorano e submetidos ou não à hipovolemia aguda: avaliação da técnica anestésica e eletrofisiologia cardíaca

Pós-graduação em Cirurgia Veterinária - FCAV

Estudo Doppler-ecocardiográfico em atletas de diferentes modalidades esportivas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeitos cardiorrespiratórios e perfil analgésico da metadona, pela via intramuscular e intravenosa, em cadelas submetidas à ovariossalpingohisterectomia

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização clínica da cardiomiopatia hipertrófica hipertensiva em cães com doença renal crônica (DRC)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo clínico da infecção natural por T. cruzi em cães residentes em uma área rural de Mato Grosso do Sul, Brasil

Pós-graduação em Medicina Veterinária - FCAV

Estudo dos aspectos clínico, laboratorial, histopatológico e do tratamento na intoxicação experimental pelo veneno da serpente Crotalus durissus terrificus em cães

Pós-graduação em Medicina Veterinária - FMVZ

Efeitos da aplicação intravenosa do cloridrato sobre a concentração alveolar mínima do sevofluorano em cães

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação dos padrões de vitalidade neonatal, hemogasometria e eletrocardiografia em equinos da raça Paint Horse

Pós-graduação em Medicina Veterinária - FMVZ

Electrocardiographic evaluation and serum cardiac troponin I levels in anemic dogs with blood parasitosis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Electrocardiographic evaluation of the degree of sedation and the isolated use of methadone in healthy dogs

Objective: The present study aimed to investigate the influence of methadone on cardiorespiratory parameters, electrocardiogram and clinical sedation in dogs. Further possible side effects are reported.Study designProspective experimental cross-over study.DogsEight, 1-4-year-old, various breeds of dogs of both genders weighing 9-36kg.MethodsEach dog was treated three times: methadone 0.3mgkg(-1) (M0.3), 0.5mgkg(-1) (M0.5) and 1.0mgkg(-1) (M1.0) intramuscularly. Respiratory rate, heart rate and arterial blood pressure were recorded as well as electrocardiographic evaluation of lead II. Clinical sedation in each treatment received a score (0-3) after drug administration and at 30minute intervals until scores and measurements returned to baseline values.ResultsA significant decrease in heart rate was seen with each dose of methadone and bradycardia (HR<60bpm) was noted in a few dogs at each dose. A clinically significant arrhythmia occurred in one dog at 1mgkg(-1) that required reversal with butorphanol. There was no significant difference in SAP, MAP and DAP between treatments. Some side effects such as salivation, defecation, vocalization and panting, after administration of methadone were observed. There were no differences in mean values of heart rate, P-wave and QRS complex duration and QT interval between treatments.Conclusion and clinical relevanceMethadone administration was associated with panting and a decrease in heart rate at all doses tested in this study. The cardiac rhythm should be monitored carefully in dogs when methadone is administered on its own, especially at higher doses.

False positivity of gamma-glutamyl transpeptidase measurement in urine

Although enzymuria tends to be associated to renal injury, there are no studies that have evaluated the presence of the enzyme gamma-glutamyl transpeptidase (GGT) spectrophotometry in the urine using a non-nephrotoxic agent (Nerium oleander) in order to evaluate the possibility of false positive results. The urinary GGT/urinary creatinine concentration ratio (uGGT/uCr) of 10 healthy dogs was calculated and posteriorly confronted with data from clinical evaluation, hematological and serum biochemical profiles, creatinine clearance (CrC), urinalysis, urine protein/creatinine ratio (UPC), electrocardiogram, systemic blood pressure (SBP) and light and electron microscopy. The results for kidney histology, SBP, UPC and CrC were not significantly different in any of the time-points analyzed. However, uGGT/uCr was significantly higher when measured 4 hours and 24 hours after administration of N. oleander. The measurement of the urinary GGT enzyme, as performed in many studies, yielded false positive results in dogs poisoned by a non-nephrotoxic agent.