Efeitos do hormônio do crescimento sobre vias de sinalização intracelular na miopatia associada à insuficiência cardíaca de ratos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência do exercício físico na remodelação cardíaca induzida pelo ácido retinóico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Influência do exercício físico sobre o estresse oxidativo, as MAPK e o NF-kB no músculo sóleo de ratos com insuficiência cardíaca induzida por estenose aórtica

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Eletrocardiografia, sedação e qualidade da recuperação do butorfanol ou buprenorfina em cães pré-tratados pela acepromazina

The aim of this work was to evaluate the electrocardiography effects (ECG), sedation time and quality of recovery due to buprenorphine (G1) and butorphanol (G2) administration in dogs pretreated with acepromazine. Seven adult dogs were submitted to both protocols, with a thirty days interval between groups. G1 animals were premedicated with acepromazine (0.1 mg/kg) followed 10 minutes later with buprenorphine (0.005 mg/kg), both applied intravenously. The same procedure was performed for G2 employing butorphanol (0.3 mg/kg) instead of buprenorphine. The measurements of the variables heart rate (HR), duration and amplitude of P wave, P-R intervals (PR), QRS complex duration, R wave amplitude, Q-T intervals (QT) and R-R intervals (RR) were taken immediately before application of acepromazine (M0), 10 minute after administration of acepromazine (M10) and 10 minutes after opioids administration (M20). Serial measurements were carried out in 10 minute intervals after the administration of butorphanol or buprenorphine up to 60 minutes. Numeric data were submitted to Tukey Analysis (p < 0.05). The amplitude of P wave decreased 30 minutes after the administration of the butorphanol. Sedation time was longer in G1 (78 minutes) than G2 (72 minutes) and recovery was good in both groups. These results indicate that butorphanol or buprenorphine produced discreet alterations on ECG, which don´t contraindicate its clinical use.

Anestesia total intravenosa (ATI) para herniorrafias umbilicais em bezerros

The total intravenous anesthesia (TIVA) is an option for some surgeries in bovines for fields. The aim of this study was to evaluate blood gases effects, cardiorespiratory and glycemia on calves submitted the umbilical herniorraphy. We used eight calves aged from 9 ± 4 months, weighting 111 ± 43 kg. The animals were pre-treated with xylazine (0.05 mg/kg IV) and after 15 minutes was administered ketamine (2.0 mg/kg IV) followed by the continuous infusion of xylazine (0.05 mg/ml), guaifenesin (50 mg/mL) and ketamine (1mg/ml) at a rate of infusion of 2mL/kg/hour. The blood gases and glucose samples were collected immediately before the MPA (MB) and the 5, 40 and 80 after the starting of TIVA (M5, M40 e M80). The other variables were measured in MB, 15 minutes after the MPA (Mx) and every 10 minutes after the starting of TIVA, entiring 80 minutes. The heart rate was higher in MB than in the other stages (p <0.05) and respiratory rate increased in M20 and M50 compared to MB and Mx (p <0.05). The PvCO2 increased while PaO2 decreased in M40 and M80, for MB (p <0.05), PVCO2 in M80 was lower than in MB (p <0.05). The pHv was smaller in M80 than M5 and MB (p <0.05), and HCO3 was lower in MB (p <0.05) compared to the others. The glucose was higher in M40 and M80 and M5 for MB (p <0.05). The recovery time was 152 ± 60 minutes after the end of the administration of the infusion of anesthetics. It was conclude that the anesthetic technique employed promoted respiratory depression, increased blood glucose and prolonged period of anesthetic recovery in calves.

Ropivacaína isolada ou associada à morfina, butorfanol ou tramadol pela via peridural em cadelas para realização de Ovariosalpingohisterectomia

The aim of this study was to investigate the use of ropivacaine combined or not with different opioids, for epidural anesthesia in bitches submitted to elective ovariosalpingohisterectomy (OSH). Thirty two mixed-breed female dogs, adults were used with medium weigh of 10.5kg. The animals were premedicated with acepromazine (0.05mg.kg-1, IM) and midazolam (0.2mg.kg-1, IM) and allocated in four experimental groups: group 1(n=8): ropivacaine: 0.3 mL.kg-1; group 2(n=8): ropivacaine + morphine (0.1 mg.kg-1); group 3(n=8): ropivacaine + butorphanol (0.1 mg.kg-1); and group 4(n=8): ropivacaine + tramadol (0.5 mg.kg-1) administered epidurally. Heart and respiratory rate; systolic arterial pressure; rectal temperature; arterial blood gas partial pressures; blood pH; sedation and muscular relaxation degree were evaluated at different experimental moments. The data were submitted to ANOVA and compared by Kruskal Wallis, Friedman, Dunn, Tukey and Chi-square test (p≤0.05). Minimum cardiorespiratory alterations were observed and the group of the ropivacaíne combined with the butorphanol (G3) presented a more cranial blockage, what allowed the accomplishment of OSH without induction in six animals (75%) whereas most of the others needed anesthetic rescue. The results allow us to conclude that the use of ropivacaine sole or combinated with morphine, butorphanol or tramadol, for epidural anesthesia, didn't promote significant cardiorrespiratory depression and the ropivacaine associated to the butorphanol allowed the accomplishment of OSH in bitches.

Ritmo sinoventricular secundário a hipercalemia em gatos com obstrução uretral: breve descrição de três casos

Hyperkalemia is a common electrolyte imbalance in cats with obstructive feline lower urinary tract disease (FLUTD). The effects of serum potassium elevation in heart rhythm are serious and potentially lethal. The clinical manifestations reflect changes in the excitability of the cell membrane. Increased potassium levels lead to a reduction of the resting membrane potential of heart muscle cells, making them less excitable and resulting in cardiac arrhythmias. The sinoventricular rhythm with atrial arrest is among the types of arrhythmias caused by hyperkalemia. The purpose of this report was to highlight the importance of electrocardiographic monitoring for the early detection of potentially lethal arrhythmias in cats with obstructive FLUTD. We hereby describe the occurrence of three cases treated at the Small Animal Clinic of FMVZ/Unesp, Botucatu Campus.

Efeito da inibição da NADPH oxidase sobre o estresse oxidativo e o fenótipo muscular esquelético de ratos com insuficiência cardíaca crônica induzida por estenose aórtica

Pós-graduação em Fisiopatologia em Clínica Médica - FMB