Influência do glyphosate em cultivares de soja rr e do herbicida nicosulfuron aplicado em híbridos de milho-pipoca em três estádios de desenvolvimento

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Cálcio, citocinina, déficit hídrico e sombreamento na fixação de estruturas reprodutivas de soja

Pós-graduação em Agronomia (Agricultura) - FCA

Identificação e análise da expressão de genes relacioanados com tolerância à seca em soja através de microarranjos de DNA e PCR em tempo real

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comparação filogenética de genomas de rizóbios por hibridização através de microarray

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Expressão gênica no parênquima mamário de novilhas leiteiras

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Validação de um microarranjo para avaliação da expressão gênica diferencial no músculo esquelético de bovinos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Caracterização parcial e patogenicidade de um vírus isolado de Thyrinteina arnobia (Stoll, 1782) (Lepidoptera: geometridae)

Pós-graduação em Agronomia (Proteção de Plantas) - FCA

Post-partum anoestrus in tropical beef cattle: A systems approach combining gene expression and genome-wide association results

The length of the post-partum anoestrous interval affects reproductive efficiency in many tropical beef cattle herds. In this study, results from genome-wide association studies (Experiment 1: GWAS) and gene expression (Experiment 2: microarray) were combined in a systems approach to reveal genetic markers, genes and pathways underlying the physiology of post-partum anoestrus in tropically adapted cattle. The microarray study measured the expression of 13,964 genes in the hypothalamus of Brahman cows. A total of 366 genes were differentially expressed (DE) in the post-partum period, when acyclic cows were compared to cows that had resumed ovarian cycles. Associated markers (P < 0.05) from a high density GWAS pointed to 2829 genes that were associated with post-partum anoestrous interval (PPAI) in two populations of beef cattle: Brahman and Tropical composite. Together the experiments provided evidence for 63 genes that are likely to influence the resumption of ovulation post-partum in tropically adapted beef cattle. Functional annotation analysis revealed that some of the 63 genes have known roles in hormonal activity, energy balance and neuronal synapse plasticity. Polymorphisms within candidate genes identified by this systems approach could have biological significance in post-partum anoestrus and help select Zebu (Bos indicus) influenced cattle with genetic potential for shorter post-partum anoestrus. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.

A tecnologia de microarray no estudo do câncer de cabeça e pescoço

(Microarray technology in study of head neck cancer). The microarray technology is a tool for global analysis of gene expression that allows investigating hundreds or thousands of genes in a sample using a hybridization reaction. This technology is based on hybridization between labeled targets derived from biological samples and an array of many DNA probes immobilized on a solid matrix, representing the genes of interest. The simultaneous study of hundreds of genes became the microarray technique a very important tool of global analysis, with applications in several areas, including the study of the development of cancer. Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer worldwide, with a global annual incidence of 780,000 new cases. Large-scale studies involving microarrays have identified specific gene expression signatures associated with expression changes in HNSCC samples compared to normal tissue, as well as genes involved in clinical outcome and metastasis. However, the considerable heterogeneity among these studies occurs due to experimental design, number of samples, disease sites and stage, choice of microarray platform and results validation. Thus, there is much to be validated, before the technique has clinical utility. In relation to head and neck neoplasia, the large-scale gene analysis is very important, since the clinical and histopathological methods currently used appear to be insufficient to predict clinical progression and response to treatment. Thus, this approach could result in more effective diagnostic and prognostic and most appropriate therapy for this neoplasia.

Nucleotídeos e ácido glutâmico em dietas de leitões desmamados

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Uso de microarray para determinação da expressão gênica diferencial em oócitos Bos Taurus Indicus e Bos Taurus Taurus submetidos ao estresse térmico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Crude glycerin in the supplement for beef cattle on pasture

Pós-graduação em Zootecnia - FCAV

Combined measurement of the Higgs Boson Mass in pp collisions at root s=7 and 8 TeV with the ATLAS and CMS experiments

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of pseudorapidity distributions of charged particles in proton-proton collisions at root s=8 TeV by the CMS and TOTEM experiments

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)