Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor

The pineal gland, the gland that translates darkness into an endocrine signal by releasing melatonin at night, is now considered a key player in the mounting of an innate immune response. Tumor necrosis factor (TNF), the first pro-inflammatory cytokine to be released by an inflammatory response, suppresses the translation of the key enzyme of melatonin synthesis (arylalkylamine-N-acetyltransferase, Aanat). Here, we show that TNF receptors of the subtype 1 (TNF-R1) are expressed by astrocytes, microglia, and pinealocytes. We also show that the TNF signaling reduces the level of inhibitory nuclear factor kappa B protein subtype A (NFKBIA), leading to the nuclear translocation of two NFKB dimers, p50/p50, and p50/RelA. The lack of a transactivating domain in the p50/p50 dimer suggests that this dimer is responsible for the repression of Aanat transcription. Meanwhile, p50/RelA promotes the expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide, which inhibits adrenergically induced melatonin production. Together, these data provide a mechanistic basis for considering pinealocytes a target ofTNF and reinforce the idea that the suppression of pineal melatonin is one of the mechanisms involved in mounting an innate immune response. © 2011 Carvalho-Sousa, da Silveira Cruz-Machado, Tamura, Fernandes, Pinato, Muxel, Cecon and Markus.

Local and regional features of surface radiation fluxes over the tropical Atlantic ocean near Sao Pedro and Sao Paulo archipelago: Evidence of small scale upwelling

To properly describe the interactions between the ocean and atmosphere, it is necessary to assess a variety of time and spatial scales phenomena. Here, high resolution oceanographic and meteorological data collected during an observational campaign carried out aboard a ship in the tropical Atlantic Ocean, on May 15-24, 2002, is used to describe the radiation balance at the ocean interface. Data collected by two PIRATA buoys, along the equator at 23°W and 35°W and satellite and climate data are compared with the data obtained during the observational campaign. Comparison indicates remarkable similarity for daily and hourly values of radiation fluxes components as consequence of the temporal and spatial consistence presented by the air and water temperatures measured in situ and estimated from large scale information. The discrepancy, mainly in the Sao Pedro and Sao Paulo Archipelago area, seems to be associated to the local upwelling of cold water, which is not detected in all other estimates investigated here. More in situ data are necessary to clarify whether this upwelling flow has a larger scale effect and what are the meteorological and oceanographic implications of the local upwelling area on the tropical waters at the Brazilian coast.

A Commentary on de Sousa′s towards an Integrative Theory of Consciousness

De Sousa′s comprehensive two-part review of a diversity of contemporary approaches to the study of consciousness is highly welcome. He makes us aware of a proliferation of theoretical and empirical approaches targeting a common theme, but diverging in many ways. He skilfully accomplishes a classification of kinds of approach, identification of the main representatives, their contributions, and respective limitations. However, he does not show how the desired integration could be accomplished. Besides summarising de Sousa′s efficient analytical work, I make critical comments and briefly report my contribution for the integration project.© MSM 2013.

Phenotypic variation of leptodactylus cupreus caramaschi, são-pedro and feio, 2008 (Anura, Leptodactylidae)

This study describes for the first time the female of Leptodactylus cupreus and provides new information concerning its geographical distribution, male's morphology and bioacustics. Leptodactylus cupreus, a poorly known species from the Brazilian Atlantic Forest, was originally allocated in the L. mystaceus complex of the L. fuscus species group. Based on morphological observations, we infer that L. cupreus should be in fact related to L. mystacinus, a species that, although assigned to the L. fuscus species group, is not assigned to the L. mystaceus complex. Therefore, we comment the phylogenetic relationships concerning L. cupreus, L. mystaceus and L. mystacinus. © 2013 Magnolia Press.

A figura humana fragmentada na pintura: Tiradentes esquartejado em Pedro Américo e Adriana Varejão

Pós-graduação em Artes - IA

O processo de intelecção em Pedro Abelardo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Os descaminhos da bem-aventurança: um estudo sobre a origem e os desdobramentos da concepção de crise paradigmática de Boaventura de Sousa Santos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Pedro Nunes e a distinção de dois tipos de trajetórias na navegação: a linha de rumo e o círculo máximo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Grupo escolar Comendador Pedro Morganti: estudo histórico sobre a cultura escolar de uma escola primária do meio rural - 1942/1988

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O arranjo de fotografias em unidades de informação: fundamentos teóricos e aplicações práticas a partir do Fundo José Pedro Miranda do Arquivo Público e Histórico de Ribeirão Preto

Pós-graduação em Ciência da Informação - FFC

Geografias do drama humano: leituras do espaço em São Bernardo, de Graciliano Ramos e Pedro Páramo, de Juan Rulfo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Teixeira e Sousa e o romance-folhetim: uma leitura de O filho do pescador (1843)

Pós-graduação em Letras - FCLAS

Propostas de recuperação de áreas peri-urbanas erodidas com base em parâmetros hidrológicos e geomorfológicos: Córrego Tucunzinho (São Pedro/SP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Lira dissonante: o grotesco na lírica romântica brasileira : considerações sobre aspecto do grotesco na poesia de Bernardo Guimarães e Cruz e Sousa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A abdicação de D. Pedro I: espaço público da política e opinião pública no final do Primeiro Reinado

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)